Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (2009)
Yu, Yong, Chu, Po-Yin, Bowser, David N., Keating, Damien J., Dubach, Daphne, Harper, Ian, ...
Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (2008)
Yu, Yong, Chu, Po-Yin, Bowser, David N., Keating, Damien J., Dubach, Daphne, Harper, Ian, ...
Enlarged early endosomes in the neurons of young Down syndrome (DS) and pre-Alzheimer’s disease (AD) brains suggest that a disturbance in endocytosis is one of the earliest hallmarks of AD...
Keating, Damien J., Dubach, Daphne, Zanin, Mark P., Yu, Yong, Martin, Katherine, Zhao, Yu-Feng, ...
Genes located on chromosome 21, over-expressed in Down syndrome (DS) and Alzheimer's disease (AD) and which regulate vesicle trafficking, are strong candidates for involvement in AD neuropathology....
Quan, Annie, McGeachie, Andrew B., Keating, Damien J., Van Dam, Ellen M., Rusak, Jenny, Chau, Ngoc, ...
Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, Sydney, Australia (A.Q., A.B.M., E.M.v.D., J.R., N.C., C.S.M., P.J.R.); Chemistry, School of Environmental and Life...
Quan, Annie, McGeachie, Andrew B., Keating, Damien J., Van Dam, Ellen M., Rusak, Jenny, Chau, Ngoc, ...
Cell Signalling Unit, Children's Medical Research Institute, University of Sydney, Sydney, Australia (A.Q., A.B.M., E.M.v.D., J.R., N.C., C.S.M., P.J.R.); Chemistry, School of Environmental and Life...
Keating, Damien J., Chen, Chen, Pritchard, Melanie A.
Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferers. Amongst these is a common early incidence of Alzheimer's disease (AD) which usually affects DS...
Keating, Damien J., Chen, Chen, Pritchard, Melanie A.
Down syndrome (DS) is a genetically-based disorder which results in multiple conditions for sufferers. Amongst these is a common early incidence of Alzheimer's disease (AD) which usually affects DS...
Feng, Dan Dan, Luo, Ziqiang, Roh, Sang-gun, Hernandez, Maria, Tawadros, Neveen, Keating, Damien J, ...
Free fatty acids (FFAs), in addition to glucose, have been shown to stimulate insulin release through the G protein-coupled receptor (GPCR)40 receptor in pancreatic ß-cells. Intracellular free...
Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways (2005)
Feng Han, Xue, Long Zhu, Yun, Hernandez, Maria, Keating, Damien J., Chen Chen
Ghrelin is an endogeneous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+...
Zhao, Yu-Feng, Keating, Damien J, Hernandez, Maria, Feng, Dan Dan, Zhu, Yulong, Chen, Chen
Dysfunction of pancreatic -cells is a fundamental feature in the pathogenesis of type 2 diabetes. As insulin receptor signaling occurs via protein tyrosine kinase (PTK), we investigated the role of...
Activin A is a member of the transforming growth factor-ß family and has known roles in the adrenal cortex, from which activin A is secreted. We aimed to find whether activin A induces secretion of...
Ghrelin reduces voltage-gated potassium currents in GH3 cells via cyclic GMP pathways (2005)
Feng Han, Xue, Long Zhu, Yun, Hernandez, Maria, Keating, Damien J., Chen Chen
Ghrelin is an endogeneous growth hormone secretagogue (GHS) causing release of GH from pituitary somatotropes through the GHS receptor. Secretion of GH is linked directly to intracellular free Ca2+...
Zhao, Yu-Feng, Keating, Damien J, Hernandez, Maria, Feng, Dan Dan, Zhu, Yulong, Chen, Chen
Dysfunction of pancreatic -cells is a fundamental feature in the pathogenesis of type 2 diabetes. As insulin receptor signaling occurs via protein tyrosine kinase (PTK), we investigated the role of...
Activin A is a member of the transforming growth factor-ß family and has known roles in the adrenal cortex, from which activin A is secreted. We aimed to find whether activin A induces secretion of...
Keating, Damien J, Rychkov, G, Rychkov, Grigori Y, Adams, Michael B, Holgert, H, McMillen, Isabella Caroline, ...
Keating, Damien J, Rychkov, G, Rychkov, Grigori Y, Adams, Michael B, Holgert, H, McMillen, Isabella Caroline, ...
Keating, Damien J, Rychkov, G, Rychkov, Grigori Y, Adams, Michael B, Holgert, H, McMillen, Isabella Caroline, ...
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
Boettger, Thomas, Rust, Marco B., Maier, Hannes, Seidenbecher, Thomas, Schweizer, Michaela, Keating, Damien J., ...
K-Cl co-transporters are encoded by four homologous genes and may have roles in transepithelial transport and in the regulation of cell volume and cytoplasmic chloride. KCC3, an isoform mutated in...
Keating, Damien J, Rychkov, Grigori Y, Adams, Michael B, Holgert, Hans, McMillen, I Caroline, Roberts, Michael L
Before the preganglionic regulation of the adrenal medulla is established, hypoxia acts directly on the chromaffin cells to evoke the secretion of catecholamines. This direct action of hypoxia is...
Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
Boettger, Thomas, Rust, Marco B., Maier, Hannes, Seidenbecher, Thomas, Schweizer, Michaela, Keating, Damien J., ...
K-Cl co-transporters are encoded by four homologous genes and may have roles in transepithelial transport and in the regulation of cell volume and cytoplasmic chloride. KCC3, an isoform mutated in...
Keating, Damien J, Rychkov, Grigori Y, Adams, Michael B, Holgert, Hans, McMillen, I Caroline, Roberts, Michael L
Before the preganglionic regulation of the adrenal medulla is established, hypoxia acts directly on the chromaffin cells to evoke the secretion of catecholamines. This direct action of hypoxia is...