Damien Leduc

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers

Leduc, Damien, Graziani, Sébastien, Lipowski, Gerard, Marchand, Christophe, Le Maréchal, Pierre, Liebl, Ursula, ...

Little is known about the catalytic mechanism of the recently discovered ThyX family of flavin-dependent thymidylate synthases that are required for thymidylate (deoxythymidine 5′-monophosphate)...

Functional evidence for active site location of tetrameric thymidylate synthase X at the interphase of three monomers

Leduc, Damien, Graziani, Sébastien, Lipowski, Gerard, Marchand, Christophe, Le Maréchal, Pierre, Liebl, Ursula, ...

Little is known about the catalytic mechanism of the recently discovered ThyX family of flavin-dependent thymidylate synthases that are required for thymidylate (deoxythymidine 5′-monophosphate)...

The Hotdog Thioesterase EntH (YbdB) Plays a Role In Vivo in Optimal Enterobactin Biosynthesis by Interacting with the ArCP Domain of EntB▿ †

Leduc, Damien, Battesti, Aurélia, Bouveret, Emmanuelle

In response to iron limitation, the siderophore enterobactin is synthesized and secreted by Escherichia coli. Its biosynthesis is performed by a series of enzymes encoded by the Ent gene cluster....

Flavin-Dependent Thymidylate Synthase ThyX Activity: Implications for the Folate Cycle in Bacteria▿ †

Leduc, Damien, Escartin, Frédéric, Nijhout, H. Frederik, Reed, Michael C., Liebl, Ursula, Skouloubris, Stéphane, ...

Although flavin-dependent ThyX proteins show thymidylate synthase activity in vitro and functionally complement thyA defects in heterologous systems, direct proof of their cellular functions is...