Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., ...
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products. We show that priming of murine bone...
Sweet, Matthew J., Campbell, Carol C., Sester, David P., Xu, Damo, McDonald, Rebecca C., Stacey, Katryn J., ...
During bacterial infections, the balance between resolution of infection and development of sepsis is dependent upon the macrophage response to bacterial products. We show that priming of murine bone...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
A proinflammatory role for IL-18 in rheumatoid arthritis
Gracie, J. Alastair, Forsey, Rosalyn J., Chan, Woon Ling, Gilmour, Ashley, Leung, Bernard P., Greer, Morag R., ...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) synovial tissues...
Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
Liu, Haiying, Komai-Koma, Mousa, Xu, Damo, Liew, Foo Y.
Toll-like receptors (TLRs) are primary sensors of both innate and adaptive immune systems and play a pivotal role in response against structurally conserved components of pathogens. Synthetic...
TLR2 is expressed on activated T cells as a costimulatory receptor
Komai-Koma, Mousa, Jones, Louise, Ogg, Graham S., Xu, Damo, Liew, Foo Y.
Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila. At least 10 distinct Toll-like receptors (TLRs), recognizing...
A proinflammatory role for IL-18 in rheumatoid arthritis
Gracie, J. Alastair, Forsey, Rosalyn J., Chan, Woon Ling, Gilmour, Ashley, Leung, Bernard P., Greer, Morag R., ...
IL-18 is a novel cytokine with pleiotropic activities critical to the development of T-helper 1 (Th1) responses. We detected IL-18 mRNA and protein within rheumatoid arthritis (RA) synovial tissues...
Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
Liu, Haiying, Komai-Koma, Mousa, Xu, Damo, Liew, Foo Y.
Toll-like receptors (TLRs) are primary sensors of both innate and adaptive immune systems and play a pivotal role in response against structurally conserved components of pathogens. Synthetic...
Eaton, Alfred D, Xu, Damo, Garside, Paul
Interleukin-18 (IL-18), a pro-inflammatory member of the IL-1 family, has been associated with autoimmunity and allergic disease. This type of pathology is thought to be the result of a defect in...
Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells
Xu, Damo, Chan, Woon Ling, Leung, Bernard P., Huang, Fang-ping, Wheeler, Rachel, Piedrafita, David, ...
T helper cell type 1 (Th1) and 2 (Th2) are central to immune regulation. However, no stable cell surface marker capable of distinguishing and separating these two subsets of CD4+ cells has yet been...
Xu, Damo, Chan, Woon Ling, Leung, Bernard P., Hunter, David, Schulz, Kerstin, Carter, Robert W., ...
Interleukin (IL)-18 induces interferon (IFN)-γ synthesis and synergizes with IL-12 in T helper type 1 (Th1) but not Th2 cell development. We report here that IL-18 receptor (IL-18R) is selectively...
IL-33 reduces the development of atherosclerosis
Miller, Ashley M., Xu, Damo, Asquith, Darren L., Denby, Laura, Li, Yubin, Sattar, Naveed, ...
Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to myocardial infarction and stroke. We show that IL-33, which is a novel IL-1–like cytokine that signals via...
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
Verri, Waldiceu A., Guerrero, Ana T. G., Fukada, Sandra Y., Valerio, Daniel A., Cunha, Thiago M., Xu, Damo, ...
IL-33, a new member of the IL-1 family, signals through its receptor ST2 and induces T helper 2 (Th2) cytokine synthesis and mediates inflammatory response. We have investigated the role of IL-33 in...
IL-33 exacerbates antigen-induced arthritis by activating mast cells
Xu, Damo, Jiang, Hui-Rong, Kewin, Peter, Li, Yubin, Mu, Rong, Fraser, Alasdair R., ...
IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed...