Dan Baeckström

c-erbB2–induced Disruption of Matrix Adhesion and Morphogenesis Reveals a Novel Role for Protein Kinase B as a Negative Regulator of α2β1 Integrin Function

Lindberg, Lachmi E., Hedjazifar, Shahram, Baeckström, Dan

Overexpression of the growth factor receptor subunit c-erbB2, leading to its ligand-independent homodimerization and activation, has been implicated in the pathogenesis of mammary carcinoma. Here, we...

Shedding and γ-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43

Andersson, Christian X., Fernandez-Rodriguez, Julia, Laos, Sirle, Baeckström, Dan, Haass, Christian, Hansson, Gunnar C.

CD43 is a transmembrane molecule that contains a 123-aminoacids-long cytoplasmic tail and a highly O-glycosylated extracellular domain of mucin type. Endogenous CD43 expressed in COLO 205, K562 and...

c-erbB2–induced Disruption of Matrix Adhesion and Morphogenesis Reveals a Novel Role for Protein Kinase B as a Negative Regulator of α2β1 Integrin Function

Lindberg, Lachmi E., Hedjazifar, Shahram, Baeckström, Dan

Overexpression of the growth factor receptor subunit c-erbB2, leading to its ligand-independent homodimerization and activation, has been implicated in the pathogenesis of mammary carcinoma. Here, we...

Shedding and γ-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43

Andersson, Christian X., Fernandez-Rodriguez, Julia, Laos, Sirle, Baeckström, Dan, Haass, Christian, Hansson, Gunnar C.

CD43 is a transmembrane molecule that contains a 123-aminoacids-long cytoplasmic tail and a highly O-glycosylated extracellular domain of mucin type. Endogenous CD43 expressed in COLO 205, K562 and...