Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...
Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....
Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...
Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....
Boneca, Ivo G, Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...
Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Philpott, Dana J., McKay, Derek M., Mak, Walter, Perdue, Mary H., Sherman, Philip M.
Enterohemorrhagic Escherichia coli (EHEC) infection is associated with watery diarrhea and can lead to complications, including hemorrhagic colitis and the hemolytic-uremic syndrome. The mechanisms...
Niebuhr, Kirsten, Giuriato, Sylvie, Pedron, Thierry, Philpott, Dana J., Gaits, Frédérique, Sable, Julia, ...
Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Recognition of Staphylococcus aureus by the Innate Immune System
Fournier, Bénédicte, Philpott, Dana J.
The gram-positive bacterium Staphylococcus aureus is a major pathogen responsible for a variety of diseases ranging from minor skin infections to life-threatening conditions such as sepsis. Cell...
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Sensing microbes by diverse hosts
Girardin, Stephen E., Philpott, Dana J., Lemaitre, Bruno
Workshop on Pattern Recognition Proteins and Receptors
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Magalhaes, Joao Gamelas, Philpott, Dana J, Nahori, Marie-Anne, Jéhanno, Muguette, Fritz, Joerg, Bourhis, Lionel Le, ...
Tracheal cytotoxin (TCT) was originally described as the minimal effector that was able to reproduce the cytotoxic response of Bordetella pertussis on ciliated epithelial cells. This molecule...
Philpott, Dana J., McKay, Derek M., Mak, Walter, Perdue, Mary H., Sherman, Philip M.
Enterohemorrhagic Escherichia coli (EHEC) infection is associated with watery diarrhea and can lead to complications, including hemorrhagic colitis and the hemolytic-uremic syndrome. The mechanisms...
Niebuhr, Kirsten, Giuriato, Sylvie, Pedron, Thierry, Philpott, Dana J., Gaits, Frédérique, Sable, Julia, ...
Phosphoinositides play a central role in the control of several cellular events including actin cytoskeleton organization. Here we show that, upon infection of epithelial cells with the Gram-negative...
CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri
Girardin, Stephen E., Tournebize, Régis, Mavris, Maria, Page, Anne-Laure, Li, Xiaoxia, Stark, George R., ...
Epithelial cells are refractory to extracellular lipopolysaccharide (LPS), yet when presented inside the cell, it is capable of initiating an inflammatory response. Using invasive Shigella flexneri...
Recognition of Staphylococcus aureus by the Innate Immune System
Fournier, Bénédicte, Philpott, Dana J.
The gram-positive bacterium Staphylococcus aureus is a major pathogen responsible for a variety of diseases ranging from minor skin infections to life-threatening conditions such as sepsis. Cell...
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition
Travassos, Leonardo H, Girardin, Stephen E, Philpott, Dana J, Blanot, Didier, Nahori, Marie-Anne, Werts, Catherine, ...
Toll-like receptor 2 (TLR2) has been shown to recognize several classes of pathogen-associated molecular patterns including peptidoglycan (PG). However, studies linking PG with TLR2 recognition have...
Sensing microbes by diverse hosts
Girardin, Stephen E., Philpott, Dana J., Lemaitre, Bruno
Workshop on Pattern Recognition Proteins and Receptors
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
Magalhaes, Joao Gamelas, Philpott, Dana J, Nahori, Marie-Anne, Jéhanno, Muguette, Fritz, Joerg, Bourhis, Lionel Le, ...
Tracheal cytotoxin (TCT) was originally described as the minimal effector that was able to reproduce the cytotoxic response of Bordetella pertussis on ciliated epithelial cells. This molecule...
Kapetanovic, Ronan, Nahori, Marie-Anne, Balloy, Viviane, Fitting, Catherine, Philpott, Dana J., Cavaillon, Jean-Marc, ...
Toll-like receptors (TLRs) are involved in the sensing of microbially derived compounds. We analyzed the contribution of these receptors to cytokine production by macrophages following stimulation...
Boneca, Ivo G., Dussurget, Olivier, Cabanes, Didier, Nahori, Marie-Anne, Sousa, Sandra, Lecuit, Marc, ...
Listeria monocytogenes is a human intracellular pathogen that is able to survive in the gastrointestinal environment and replicate in macrophages, thus bypassing the early innate immune defenses....
NF-κB Activation during Acute Helicobacter pylori Infection in Mice▿
Ferrero, Richard L., Avé, Patrick, Ndiaye, Delphine, Bambou, Jean-Christophe, Huerre, Michel R., Philpott, Dana J., ...
Nuclear factor κB (NF-κB) plays a key regulatory role in host cell responses to Helicobacter pylori infection in humans. Although mice are routinely used as a model to study H. pylori pathogenesis,...
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
Joosten, Leo A. B., Heinhuis, Bas, Abdollahi-Roodsaz, Shahla, Ferwerda, Gerben, LeBourhis, Lionel, Philpott, Dana J., ...
The pathogenesis of chronic joint inflammation remains unclear, although the involvement of pathogen recognition receptors has been suggested recently. In the present article, we describe the role of...
Tattoli, Ivan, Carneiro, Leticia A, Jéhanno, Muguette, Magalhaes, Joao G, Shu, Youmin, Philpott, Dana J, ...
NOD-like receptors (NLRs) are a family of intracellular sensors of microbial- or danger-associated molecular patterns. Here, we report the identification of NLRX1, which is a new member of the NLR...
Chaouche-Drider, Nadia, Kaparakis, Maria, Karrar, Abdulgader, Fernandez, Maria-Isabel, Carneiro, Letitia A. M., Viala, Jérôme, ...
Helicobacter spp. represent a proportionately small but significant component of the normal intestinal microflora of animal hosts. Several of these intestinal Helicobacter spp. are known to induce...