Campellone, Kenneth Geno, Brady, Michael J., Alamares, Judith G., Rowe, Daniel C., Skehan, Brian M., Tipper, Donald J., ...
Enterohaemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) both utilize type III secretion systems that translocate the effector protein Tir into the plasma membrane of mammalian...
Over the last decade, the innate immune system has been the subject of extensive research. Often overlooked by the robustness and specificity of the adaptive immune system, the innate immune system...
McGettrick, Anne F., Brint, Elizabeth K., Palsson-McDermott, Eva M., Rowe, Daniel C., Golenbock, Douglas T., Gay, Nicholas J., ...
PKCepsilon has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKCepsilon in LPS signaling is unknown. LPS signaling is mediated by...
Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, ...
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively...
Endotoxin recognition and signal transduction by the TLR4/MD2-complex (2004)
Fitzgerald, Katherine A., Rowe, Daniel C., Golenbock, Douglas T.
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of...
McWhirter, Sarah M., Fitzgerald, Kate A., Rosains, Jacqueline, Rowe, Daniel C., Golenbock, Douglas T., Maniatis, Tom
Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression of genes encoding IFN-alpha and -beta and chemokines, such as RANTES (regulated on activation, normal T cell...
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF (2003)
Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, ...
Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in...
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway (2003)
Fitzgerald, Katherine A., McWhirter, Sarah M., Faia, Kerrie L., Rowe, Daniel C., Latz, Eicke, Golenbock, Douglas T., ...
The transcription factors interferon regulatory factor 3 (IRF3) and NF-kappaB are required for the expression of many genes involved in the innate immune response. Viral infection, or the binding of...
McWhirter, Sarah M., Fitzgerald, Katherine A., Rosains, Jacqueline, Rowe, Daniel C., Golenbock, Douglas T., Maniatis, Tom
Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression of genes encoding IFN-α and -β and chemokines, such as RANTES (regulated on activation, normal T cell...
Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, ...
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively...
Trif-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling
McGettrick, Anne F., Brint, Elizabeth K., Palsson-McDermott, Eva M., Rowe, Daniel C., Golenbock, Douglas T., Gay, Nicholas J., ...
PKCε has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKCε in LPS signaling is unknown. LPS signaling is mediated by Toll-like...
McWhirter, Sarah M., Fitzgerald, Katherine A., Rosains, Jacqueline, Rowe, Daniel C., Golenbock, Douglas T., Maniatis, Tom
Virus infection, double-stranded RNA, and lipopolysaccharide each induce the expression of genes encoding IFN-α and -β and chemokines, such as RANTES (regulated on activation, normal T cell...
Rowe, Daniel C., McGettrick, Anne F., Latz, Eicke, Monks, Brian G., Gay, Nicholas J., Yamamoto, Masahiro, ...
TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively...
Trif-related adapter molecule is phosphorylated by PKCε during Toll-like receptor 4 signaling
McGettrick, Anne F., Brint, Elizabeth K., Palsson-McDermott, Eva M., Rowe, Daniel C., Golenbock, Douglas T., Gay, Nicholas J., ...
PKCε has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKCε in LPS signaling is unknown. LPS signaling is mediated by Toll-like...
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, ...
Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN-β (TRIF)–related adaptor molecule (TRAM) is the fourth TIR domain–containing adaptor protein to be described that...