Dirk Helbing, Martin Schönhof, Daniel Kern
and traffic optimization
Frechin, Mathieu, Senger, Bruno, Brayé, Mélanie, Kern, Daniel, Martin, Robert Pierre, Becker, Hubert Dominique
It is impossible to predict which pathway, direct glutaminylation of tRNAGln or tRNA-dependent transamidation of glutamyl-tRNAGln, generates mitochondrial glutaminyl-tRNAGln for protein synthesis in...
Remco Chang, Mohammad Ghoniem, Robert Kosara, William Ribarsky, Jing Yang, Evan Suma, ...
Large financial institutions such as Bank of America handle hundreds of thousands of wire transactions per day. Although most transactions are legitimate, these institutions have legal and financial...
EU - DIALOG & KOMMUNIKATION (2008)
Kern, Daniel, Rasmussen, Laurits
From next school year governmental regulations require more focus on the EU in primary school curriculum. At technical schools and other educational establishments within trade and business they have...
Structural elements defining elongation factor Tu mediated suppression of codon ambiguity (2007)
Roy, Hervé, Becker, Hubert Dominique, Mazauric, Marie-Hélène, Kern, Daniel
In most prokaryotes Asn-tRNAAsn and Gln-tRNAGln are formed by amidation of aspartate and glutamate mischarged onto tRNAAsn and tRNAGln, respectively. Coexistence in the organism of mischarged...
Deniziak, Marzanna, Sauter, Claude, Becker, Hubert Dominique, Paulus, Caroline Alexandra, Giegé, Richard, Kern, Daniel
Glutaminyl-tRNA synthetase from Deinococcus radiodurans possesses a C-terminal extension of 215 residues appending the anticodon-binding domain. This domain constitutes a paralog of the Yqey protein...
Deniziak, Marzanna, Sauter, Claude, Becker, Hubert Dominique, Paulus, Caroline Alexandra, Giegé, Richard, Kern, Daniel
Glutaminyl-tRNA synthetase from Deinococcus radiodurans possesses a C-terminal extension of 215 residues appending the anticodon-binding domain. This domain constitutes a paralog of the Yqey protein...
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine (2006)
Bailly, Marc, Giannouli, Stamatina, Blaise, Mickael, Stathopoulos, Constantinos, Kern, Daniel, Becker, Hubert Dominique
In many prokaryotes and in organelles asparagine and glutamine are formed by a tRNA-dependent amidotransferase (AdT) that catalyzes amidation of aspartate and glutamate, respectively, mischarged on...
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine (2006)
Bailly, Marc, Giannouli, Stamatina, Blaise, Mickael, Stathopoulos, Constantinos, Kern, Daniel, Becker, Hubert Dominique
In many prokaryotes and in organelles asparagine and glutamine are formed by a tRNA-dependent amidotransferase (AdT) that catalyzes amidation of aspartate and glutamate, respectively, mischarged on...
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine (2006)
Bailly, Marc, Giannouli, Stamatina, Blaise, Mickael, Stathopoulos, Constantinos, Kern, Daniel, Becker, Hubert Dominique
In many prokaryotes and in organelles asparagine and glutamine are formed by a tRNA-dependent amidotransferase (AdT) that catalyzes amidation of aspartate and glutamate, respectively, mischarged on...
Blaise, Mickaël, Becker, Hubert Dominique, Keith, Gérard, Cambillau, Christian, Lapointe, Jacques, Giegé, Richard, ...
Escherichia coli encodes YadB, a protein displaying 34% identity with the catalytic core of glutamyl‐tRNA synthetase but lacking the anticodon‐binding domain. We show that YadB is a...
Helbing, Dirk, Schoenhof, Martin, Kern, Daniel
The coordinated and efficient distribution of limited resources by individual decisions is a fundamental, unsolved problem. When individuals compete for road capacities, time, space, money, goods,...
Kreutzer, Roland, Kern, Daniel, Giegè, R., Rudinger, Joëlle
The phosphates of the tRNAPhe transcript from Thermus thermophilus interacting with the cognate synthetase were determined by footprinting. Backbone bond protection against cleavage by iodine of the...
Sequence of tRNAAsp form Thermus thermophilus HB8 (1993)
Keith, Geèrard, Yusupov, Marat, Brion, Christian, Moras, Dino, Kern, Daniel
Kern, Daniel, Lapointe, Jacques
The substrates-induced protection against the heat-inactivation of the glutamyl-tRNA synthetase has been investigated. tRNAG°u and ATP protect efficiently the enzyme, whereas glutamate does not. In...
Thermus thermophilus: A link in evolution of the tRNA-dependent amino acid amidation pathways
Becker, Hubert Dominique, Kern, Daniel
Thermus thermophilus possesses an aspartyl-tRNA synthetase (AspRS2) able to aspartylate efficiently tRNAAsp and tRNAAsn. Aspartate mischarged on tRNAAsn then is converted into asparagine by an ω...
Charron, Christophe, Roy, Hervé, Blaise, Mickael, Giegé, Richard, Kern, Daniel
In most organisms, tRNA aminoacylation is ensured by 20 aminoacyl-tRNA synthetases (aaRSs). In eubacteria, however, synthetases can be duplicated as in Thermus thermophilus, which contains two...
When contemporary aminoacyl-tRNA synthetases invent their cognate amino acid metabolism
Roy, Hervé, Becker, Hubert Dominique, Reinbolt, Joseph, Kern, Daniel
Faithful protein synthesis relies on a family of essential enzymes called aminoacyl-tRNA synthetases, assembled in a piecewise fashion. Analysis of the completed archaeal genomes reveals that all...
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon
Blaise, Mickaël, Becker, Hubert Dominique, Keith, Gérard, Cambillau, Christian, Lapointe, Jacques, Giegé, Richard, ...
Escherichia coli encodes YadB, a protein displaying 34% identity with the catalytic core of glutamyl-tRNA synthetase but lacking the anticodon-binding domain. We show that YadB is a tRNA modifying...
Dubois, Daniel Y., Blaise, Mickaël, Becker, Hubert D., Campanacci, Valérie, Keith, Gérard, Giegé, Richard, ...
The product of the Escherichia coli yadB gene is homologous to the N-terminal part of bacterial glutamyl-tRNA synthetases (GluRSs), including the Rossmann fold with the acceptor-binding domain and...
Thermus thermophilus: A link in evolution of the tRNA-dependent amino acid amidation pathways
Becker, Hubert Dominique, Kern, Daniel
Thermus thermophilus possesses an aspartyl-tRNA synthetase (AspRS2) able to aspartylate efficiently tRNAAsp and tRNAAsn. Aspartate mischarged on tRNAAsn then is converted into asparagine by an ω...
Charron, Christophe, Roy, Hervé, Blaise, Mickael, Giegé, Richard, Kern, Daniel
In most organisms, tRNA aminoacylation is ensured by 20 aminoacyl-tRNA synthetases (aaRSs). In eubacteria, however, synthetases can be duplicated as in Thermus thermophilus, which contains two...
When contemporary aminoacyl-tRNA synthetases invent their cognate amino acid metabolism
Roy, Hervé, Becker, Hubert Dominique, Reinbolt, Joseph, Kern, Daniel
Faithful protein synthesis relies on a family of essential enzymes called aminoacyl-tRNA synthetases, assembled in a piecewise fashion. Analysis of the completed archaeal genomes reveals that all...
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon
Blaise, Mickaël, Becker, Hubert Dominique, Keith, Gérard, Cambillau, Christian, Lapointe, Jacques, Giegé, Richard, ...
Escherichia coli encodes YadB, a protein displaying 34% identity with the catalytic core of glutamyl-tRNA synthetase but lacking the anticodon-binding domain. We show that YadB is a tRNA modifying...
Dubois, Daniel Y., Blaise, Mickaël, Becker, Hubert D., Campanacci, Valérie, Keith, Gérard, Giegé, Richard, ...
The product of the Escherichia coli yadB gene is homologous to the N-terminal part of bacterial glutamyl-tRNA synthetases (GluRSs), including the Rossmann fold with the acceptor-binding domain and...
A single tRNA base pair mediates bacterial tRNA-dependent biosynthesis of asparagine
Bailly, Marc, Giannouli, Stamatina, Blaise, Mickael, Stathopoulos, Constantinos, Kern, Daniel, Becker, Hubert Dominique
In many prokaryotes and in organelles asparagine and glutamine are formed by a tRNA-dependent amidotransferase (AdT) that catalyzes amidation of aspartate and glutamate, respectively, mischarged on...
Deniziak, Marzanna, Sauter, Claude, Becker, Hubert Dominique, Paulus, Caroline Alexandra, Giegé, Richard, Kern, Daniel
Glutaminyl-tRNA synthetase from Deinococcus radiodurans possesses a C-terminal extension of 215 residues appending the anticodon-binding domain. This domain constitutes a paralog of the Yqey protein...
Structural elements defining elongation factor Tu mediated suppression of codon ambiguity
Roy, Hervé, Becker, Hubert Dominique, Mazauric, Marie-Hélène, Kern, Daniel
In most prokaryotes Asn-tRNAAsn and Gln-tRNAGln are formed by amidation of aspartate and glutamate mischarged onto tRNAAsn and tRNAGln, respectively. Coexistence in the organism of mischarged...
Pujol, Claire, Bailly, Marc, Kern, Daniel, Maréchal-Drouard, Laurence, Becker, Hubert, Duchêne, Anne-Marie
Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but Gln-tRNA is an exception to this rule. Gln-tRNAGln is formed by this direct...
Frechin, Mathieu, Senger, Bruno, Brayé, Mélanie, Kern, Daniel, Martin, Robert Pierre, Becker, Hubert Dominique
It is impossible to predict which pathway, direct glutaminylation of tRNAGln or tRNA-dependent transamidation of glutamyl-tRNAGln, generates mitochondrial glutaminyl-tRNAGln for protein synthesis in...