Scientific Commons: Daniel Krappmann

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G0/G1-to-S-Phase Transition

Hinz, Michael, Krappmann, Daniel, Eichten, Alexandra, Heder, Andreas, Scheidereit, Claus, Strauss, Michael

Nuclear factor kappa B (NF-κB) has been implicated in the regulation of cell proliferation, transformation, and tumor development. We provide evidence for a direct link between NF-κB activity and...

Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα

Heissmeyer, Vigo, Krappmann, Daniel, Hatada, Eunice N., Scheidereit, Claus

p105 (NFKB1) acts in a dual way as a cytoplasmic IκB molecule and as the source of the NF-κB p50 subunit upon processing. p105 can form various heterodimers with other NF-κB subunits, including...

B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's

Krappmann, Daniel, Patke, Alina, Heissmeyer, Vigo, Scheidereit, Claus

Antigen receptor signaling is known to activate NF-κB in lymphocytes. While T-cell-receptor-induced NF-κB activation critically depends on novel protein kinase C θ (PKCθ), the role of novel PKCs...

Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-κB

Mathas, Stephan, Hinz, Michael, Anagnostopoulos, Ioannis, Krappmann, Daniel, Lietz, Andreas, Jundt, Franziska, ...

AP-1 family transcription factors have been implicated in the control of proliferation, apoptosis and malignant transformation. However, their role in oncogenesis is unclear and no recurrent...

Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling

Scharschmidt, Erika, Wegener, Elmar, Heissmeyer, Vigo, Rao, Anjana, Krappmann, Daniel

Bcl10 is a critical regulator of NF-κB activity in T and B cells, coupling antigen receptor signaling to NF-κB activation via protein kinase C (PKC). Here we show that PKC or T-cell receptor...

The IκB Kinase Complex and NF-κB Act as Master Regulators of Lipopolysaccharide-Induced Gene Expression and Control Subordinate Activation of AP-1

Krappmann, Daniel, Wegener, Elmar, Sunami, Yoshiaki, Esen, Meral, Thiel, Andreas, Mordmuller, Benjamin, ...

Toll-like receptors (TLRs) recognize conserved products of microbial pathogens to initiate the innate immune response. TLR4 signaling is triggered upon binding of lipopolysaccharides (LPS) from...

Viral targeting of the interferon-β-inducing Traf family member-associated NF-κB activator (TANK)-binding kinase-1

Unterstab, Gunhild, Ludwig, Stephan, Anton, Aline, Planz, Oliver, Dauber, Bianca, Krappmann, Daniel, ...

Expression of the antiviral cytokines IFN-α/β is among the most potent innate defenses of higher vertebrates to virus infections, which is controlled by the inducible transcription factor IFN...

Tissue-Specific Expression of a Splicing Mutation in the IKBKAP Gene Causes Familial Dysautonomia

Slaugenhaupt, Susan A., Blumenfeld, Anat, Gill, Sandra P., Leyne, Maire, Mull, James, Cuajungco, Math P., ...

Familial dysautonomia (FD; also known as “Riley-Day syndrome”), an Ashkenazi Jewish disorder, is the best known and most frequent of a group of congenital sensory neuropathies and is...

Lymphotoxin and lipopolysaccharide induce NF-κB-p52 generation by a co-translational mechanism

Mordmüller, Benjamin, Krappmann, Daniel, Esen, Meral, Wegener, Elmar, Scheidereit, Claus

The 'classical' NF-κB activation pathway proceeds via IκB kinase (IKK)-β/γ-mediated phosphorylation, induced ubiquitination and the degradation of small IκBs. An alternative, NF-κB-inducing...

A pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways

Krappmann, Daniel, Scheidereit, Claus

The nuclear factor (NF)-κB pathway is a paradigm for gene expression control by ubiquitin-mediated protein degradation. In stimulated cells, phosphorylation by the IκB kinase (IKK) complex primes...