Ganusov, Vitaly V., Barber, Daniel L., De Boer, Rob J.
It has been difficult to measure efficacy of T cell-based vaccines and to correlate efficacy of CD8$^+$T cell responses with protection against viral infections. In part, this difficulty is due to...
Adaptive Tolerance and Clonal Anergy Are Distinct Biochemical States 1 (2009)
Lynda Chiodetti, Seeyoung Choi, Daniel L. Barber, Ronald H. Schwartz
Adaptive tolerance is a process by which T cells become desensitized when Ag stimulation persists following an initial immune response in vivo. To examine the biochemical changes in TCR signaling...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
Antigen-independent memory CD8 T cells do not develop during chronic viral infection
Wherry, E. John, Barber, Daniel L., Kaech, Susan M., Blattman, Joseph N., Ahmed, Rafi
Memory T cells can persist for extended periods in the absence of antigen, and long-term T cell immunity is often seen after acute infections. Paradoxically, there have been observations suggesting...
Estimation of the rate of killing by cytotoxic T lymphocytes in vivo
Regoes, Roland R., Barber, Daniel L., Ahmed, Rafi, Antia, Rustom
Cytotoxic T lymphocytes (CTL) help control virus infections by killing virus-infected (target) cells. How fast do CTL find and kill target cells in vivo? Experiments allow us to follow populations of...
Revisiting Estimates of CTL Killing Rates In Vivo
Yates, Andrew, Graw, Frederik, Barber, Daniel L., Ahmed, Rafi, Regoes, Roland R., Antia, Rustom
Recent experimental advances have allowed the estimation of the in vivo rates of killing of infected target cells by cytotoxic T lymphocytes (CTL). We present several refinements to a method applied...
Vezys, Vaiva, Masopust, David, Kemball, Christopher C., Barber, Daniel L., O'Mara, Leigh A., Larsen, Christian P., ...
Numerous microbes establish persistent infections, accompanied by antigen-specific CD8 T cell activation. Pathogen-specific T cells in chronically infected hosts are often phenotypically and...
Ha, Sang-Jun, Mueller, Scott N., Wherry, E. John, Barber, Daniel L., Aubert, Rachael D., Sharpe, Arlene H., ...
Therapeutic vaccination is a potentially promising strategy to enhance T cell immunity and viral control in chronically infected individuals. However, therapeutic vaccination approaches have fallen...