Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons (2007)
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M, Boffelli, Dario
Abstract Background Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis -regulatory elements based on constrained sequence evolution. However, these...
Symbiosis insights through metagenomic analysis of a microbial consortium (2006)
Woyke, Tanja, Teeling, Hanno, Ivanova, Natalia N., Hunteman, Marcel, Richter, Michael, Gloeckner, Frank Oliver, ...
Primate-specific evolution of an LDLR enhancer (2006)
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M, Chanan, Sumita, Brown, Myles, ...
Background Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. Results In this...
Primate-Specific Evolution of an LDLR Enhancer (2006)
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, ...
Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. In this study, we...
Detection of Weakly Conserved Ancestral Mammalian Regulatory Sequences by Primate Comparisons (2006)
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M., Boffelli, Dario
Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis-regulatory elements based on constrained sequence evolution. However, these methods fail to detect...
Primate-specific evolution of an LDLR enhancer (2005)
Wang, Qian-Fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, ...
Intra-species sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
eShadow: A tool for comparing closely related sequences (2004)
Ovcharenko, Ivan, Boffelli, Dario, Loots, Gabriela G.
Primate sequence comparisons are difficult to interpret due to the high degree of sequence similarity shared between such closely related species. Recently, a novel method, phylogenetic shadowing,...
eShadow: A Tool for Comparing Closely Related Sequences (2004)
Ovcharenko, Ivan, Boffelli, Dario, Loots, Gabriela G.
Primate sequence comparisons are difficult to interpret due to the high degree of sequence similarity shared between such closely related species. Recently, a novel method, phylogenetic shadowing,...
Intraspecies sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Intraspecies sequence comparisons for annotating genomes (2004)
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Convergent evolution in primates and an insectivore (2003)
Boffelli, Dario, Cheng, Jan-Fang, Rubin, Edward M.
The cardiovascular risk factor apolipoprotein(a) (apo(a)) has a puzzling distribution among mammals, its presence being limited to a subset of primates and a member of the insectivore lineage, the...
Lipid absorption in the small intestine [microform] : mechanism and inhibition / (1996)
Thesis (doctoral)--Swiss Federal Institute of Technology Zurich, 1996.
Lipid absorption in the small intestine : mechanism and inhibition / (1996)
Diss. no. 11809 nat. sc. SFIT Zurich.
Genomic interval engineering of mice identifies a novel modulator of triglyceride production
Zhu, Yiwen, Jong, Miek C., Frazer, Kelly A., Gong, Elaine, Krauss, Ronald M., Cheng, Jan-Fang, ...
To accelerate the biological annotation of novel genes discovered in sequenced regions of mammalian genomes, we are creating large deletions in the mouse genome targeted to include clusters of such...
Molecular cloning of a peroxisomal Ca2+-dependent member of the mitochondrial carrier superfamily
Weber, Franz E., Minestrini, Gianluca, Dyer, James H., Werder, Moritz, Boffelli, Dario, Compassi, Sabina, ...
A cDNA from a novel Ca2+-dependent member of the mitochondrial solute carrier superfamily was isolated from a rabbit small intestinal cDNA library. The full-length cDNA clone was 3,298 nt long and...
eShadow: A Tool for Comparing Closely Related Sequences
Ovcharenko, Ivan, Boffelli, Dario, Loots, Gabriela G.
Primate sequence comparisons are difficult to interpret due to the high degree of sequence similarity shared between such closely related species. Recently, a novel method, phylogenetic shadowing,...
Intraspecies sequence comparisons for annotating genomes
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Genomic interval engineering of mice identifies a novel modulator of triglyceride production
Zhu, Yiwen, Jong, Miek C., Frazer, Kelly A., Gong, Elaine, Krauss, Ronald M., Cheng, Jan-Fang, ...
To accelerate the biological annotation of novel genes discovered in sequenced regions of mammalian genomes, we are creating large deletions in the mouse genome targeted to include clusters of such...
Molecular cloning of a peroxisomal Ca2+-dependent member of the mitochondrial carrier superfamily
Weber, Franz E., Minestrini, Gianluca, Dyer, James H., Werder, Moritz, Boffelli, Dario, Compassi, Sabina, ...
A cDNA from a novel Ca2+-dependent member of the mitochondrial solute carrier superfamily was isolated from a rabbit small intestinal cDNA library. The full-length cDNA clone was 3,298 nt long and...
eShadow: A Tool for Comparing Closely Related Sequences
Ovcharenko, Ivan, Boffelli, Dario, Loots, Gabriela G.
Primate sequence comparisons are difficult to interpret due to the high degree of sequence similarity shared between such closely related species. Recently, a novel method, phylogenetic shadowing,...
Intraspecies sequence comparisons for annotating genomes
Boffelli, Dario, Weer, Claire V., Weng, Li, Lewis, Keith D., Shoukry, Malak I., Pachter, Lior, ...
Analysis of sequence variation among members of a single species offers a potential approach to identify functional DNA elements responsible for biological features unique to that species. Due to its...
Primate-specific evolution of an LDLR enhancer
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M, Chanan, Sumita, Brown, Myles, ...
Analysis of primate-specific evolution of the LDL receptor enhancer demonstrates a molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions.
Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M, Boffelli, Dario
Intra-primate genome comparisons identify functional modules that are undetected by comparisons with non-mammalian genomes.