David A. Brown

THE EFFECT OF ALL-TRANS RETINOIC ACID AND FATTY ACIDS ON MCF-7 BREAST CANCER CELL PROGRESSION (2009)

Brown, David A

Vitamin A metabolites and retinoids may slow the progression of breast cancer and elicit anti-neoplastic properties similar to those of omega-3 fatty acids. Studies using animal models show a...

Key Words: Ability-focused physical therapy, Genmlization, Goal attainment scaling, Motor leurning, (2009)

David A Brown, Susan K E$gen, Robert J Palisano

Background and Purpose. Do individuals with severely limited physical and cognitive abilities improve their gross motor abilities when given physical therapy intervention, and does improvement...

Direction-Dependent Phasing of Locomotor Muscle Activity is Altered Post-Stroke Sheila Schindler-Ivens (2008)

David A. Brown, John D. Brooke, Running Head, Locomotor Muscle, Phasing Post-stroke

A major contributor to impaired locomotion post-stroke is abnormal phasing of muscle activity. While inappropriate paretic muscle phasing adapts to changing body orientation, load, and speed, it...

Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart (2008)

Brown, David A., Aon, Miguel A., Akar, Fadi G., Liu, Ting, Sorarrain, Nicolas, O’Rourke, Brian

Aims Recent evidence indicates that the activity of energy-dissipating ion channels in the mitochondria can influence the susceptibility of the heart to ischaemia–reperfusion injury. In this study,...

Towards Core Image Processing with Self-Organizing Maps Abstract (2007)

David A Brown

Artificial neural networks (ANNs) have found widespread application in human image processing systems, but often they play only a small part in a large complex process. We investigate the...

Measurements of the Dynamic Complex Young's and Shear Moduli of Chlorotrifluoroethylene (Kel-F) (Trademark) Using a Resonant Bar Technique (2006)

Brown, David A.

The material Kel-F is a candidate for use as a mechanical transducer in applications requiring small volume, lightweight sensors. However, there is concern that the temperature dependence of its...

A High Energy Nuclear Database Proposal (2005)

Brown, David A., Vogt, Ramona

We propose to develop a high-energy heavy-ion experimental database and make it accessible to the scientific community through an on-line interace. This database will be searchable and cross-indexed...

AN INVESTIGATION OF SPIN AXIS INSTRUMENT BEARINGS. (2005)

BROWN,David A., Hays,Donald A., Russell,Patrick G.

The research is concerned with problems arising in the performance of spin axis instrument bearings when used in high angular momentum gyroscope wheels. The main research efforts have been in bearing...

REDUCTION BY ORGANOMETALLIC COMPLEXES (2005)

BROWN,DAVID A., HARGADEN,J.P., SLOAN,H.

Solutions of azobenzene (.01 M) and tricarbonylarenechromiums (.01 M), RC6H5(CO)3, in dulute ethanolic hydrochloric acid (.01 M) under N give fair yields (up to 30%) of benzidine dihydrochloride,...

A Henri Nouwen workbook / (2005)

Brown, David A. (David Arthur)

Thesis (D.Min.)--Lutheran Theological Seminary at Philadelphia, 2005.

3D Imaging in Heavy-Ion Reactions (2004)

Brown, David A., Danielewicz, Pawel, Heffner, Mike, Soltz, Ron

We report an extension of the source imaging method for imaging full three-dimensional sources from three-dimensional like-pair correlations. Our technique consists of expanding the correlation data...

A Bicyclic Monoterpene Diol and UVB Stimulate BRCA1 Phosphorylation in Human Keratinocytes¶ (2003)

Matthew T. Canning, David A. Brown, Daniel B. Yarosh

BRCA1 (breast cancer–associated gene 1) is a tumor suppressor gene that plays a role in DNA repair when phosphorylated. Many DNA-damaging agents including UVC and hydrogen peroxide have been shown...

Macrophage inhibitory cytokine 1 in fetal membranes and amniotic fluid from pregnancies with and without preterm labour and premature rupture of membranes (2003)

Keelan, Jeffrey A., Wang, Kaye, Chaiworapongsa, Tinnakorn, Romero, Roberto, Mitchell, Murray D., Sato, Timothy A., ...

The placenta and fetal membranes are the site of expression of macrophage inhibitory cytokine (MIC‐1), a member of the transforming growth factor (TGF)‐β superfamily. We hypothesized that...

A SOM Based Approach to Skin Detection with (2001)

Application In Real, David A Brown, Ian Craw, Julian Lewthwaite

A large body of human image processing techniques use skin detection as a first primitive for subsequent feature extraction. Well established methods of colour modelling, such as histograms and...

Experimental and Theoretical Studies of Rotational Barriers in Aceto-, N-Methylaceto- and N-Phenylacetohydroxamic Acid (2001)

Brown, David A., Cuffe, Laurence P., Fitzpatrick, Geraldine M., Fitzpatrick, Noel J., Glass, William K., Herlihy, Kara M.

Experimental and theoretical calculations for the E and Z forms of aceto-, N-methylaceto- and N-phenylacetohydroxamic acid are reported. The experimental method was NMR spectroscopy, while the...

Is it possible to reconstruct the freeze-out duration of heavy-ion collisions using tomography? (2000)

Brown, David A.

We investigate what conditions allow us to extract the relative distribution of freeze-out space and time points in an arbitrary reference frame using tomography and source imaging. The source...

Extracting particle freeze-out phase-space densities and entropies from sources imaged in heavy-ion reactions (2000)

Brown, David A., Panitkin, Sergei Y., Bertsch, George F.

The space-averaged phase-space density and entropy per particle are both fundamental observables which can be extracted from the two-particle correlation functions measured in heavy-ion collisions....

Implications of the unusual structure in the pp correlation from Pb+Pb collisions at 158 AGeV (1999)

Brown, David A., Wang, Fuqiang, Danielewicz, Pawel

The recent NA49 measurement of two-proton correlation function shows an interesting and unexpected structure at large relative momentum. Applying source imaging techniques to the measurement, we find...

Imaging Three-Dimensional Relative Sources from Nuclear Reactions (1999)

Brown, David A.

One can access the space-time development of a heavy-ion reaction directly by imaging the source function from two particle correlation functions. In the case of like-charged pions, this imaging can...

Accessing the Space-Time Development of Heavy-Ion Collisions With Theory And Experiment (1998)

Brown, David A.

This thesis describes two lines of work. The first line is a study of the application of transport theory to massless particles, such as the partons in an ultrarelativistic collision at RHIC. The...

TUNGSTEN AND ROCKET MOTORS (1998)

GORDON,GERALD M., BROWN,DAVID A.

This report concerns the use of W in solid propellant rocket motors and involves two main areas of interest. The first area, W erosion, is being studied under simulated exhaust conditions by means of...

TUNGSTEN AND ROCKET MOTORS (1998)

GORDON,GERALD M., BROWN,DAVID A.

The investigation was continued on the use of tungsten in solid propellant rocket motors and involves two main areas of interest. The first area, tungsten erosion, is being studied under simulated...

Intifada & The Blood of Abraham. "Lessons in Asymmetrical Warfare-- Written in Stone". (1998)

Brown, David A.

A historical case study concerning the Israeli Army's response to the Palestinian "Intifada" or uprising in the late 1980's and early 1990's provides instructive planning considerations for likely...

The Quota Allocation Model: The Linear Optimization of a Markov Decision Process (1998)

Brown, David A.

One of the many needs of the Air Force is advanced technical degrees. These degrees can be acquired in three ways: the Air Force can directly recruit personnel with the required degrees; Air Force...

Homeland Defense: National Guard Bureau Needs to Clarify Civil Support Teams' Mission and Address Management Challenges (1998)

D'Agostino, Davi M., Borseth, Ann, Bendell, Bari L., Bowland, Jaclyn A., Brown, David A., Coffey, Carole F., ...

To prepare for potential attacks in the United States involving weapons of mass destruction (WMD), Congress approved the development of National Guard Civil Support Teams (CST) tasked to identify...

Flextensional Hydrophone. (1998)

Brown, David A.

An omnidirectional hydrophone having an elastic shell in the form of an oblate ellipsoid of revolution having the ratio of its major axis to is minor axis greater than about V(2-v) where v is...

Fiber Optic Flexural Disk Accelerometer. (1998)

Brown, David A., Garrett, Steven L., Hofler, Thomas J.

An accelerometer or seismometer has a pair of flat spirals of optical fiber and has one or more elastic disks bearing a mass and supported for flexure. Each spiral is fixedly attached to a...

Fiber Optic Accelerometer With Centrally Supported Flexural Disk. (1998)

Hofler, Thomas J., Brown, David A., Garrett, Steven L.

An accelerometer or seismometer has an elastic disk bearing a mass distributed peripherally around the disk. The disk is supported for flexure and for isolation from mounting strain by a stob...

Intifada and the blood of Abraham. "Lessons in asymmetrical warfare-- written in stone". (1998)

Brown, David A.

A historical case study concerning the Israeli Army's response to the Palestinian "Intifada" or uprising in the late 1980's and early 1990's provides instructive planning considerations for likely...

Medusa's Mirror: Stepping Forward to Look Back "Future UAV Design Implications from the 21st Century Battlefield" (1998)

Brown, David A.

This paper intends to explore the differences between a general purpose and a functional design approach, and will attempt to answer the question of which of these approaches will best serve the...

Partons in Phase Space (1998)

Brown, David A., Danielewicz, Pawel

Within QED, we examine several issues related to constructing a parton-model-based QCD transport theory. We rewrite the QED analog of the parton model, the Weizsaecker-Williams Approximation,...

An assessment of computer integration within education comparing rural and suburban school environments / (1998)

Brown, David A.

Examines the present state of the availability and use of technology in rural and suburban school districts.

Medusa's mirror: stepping forward to look back: "Future UAV design implications from the 21st century battlefield". (1997)

Brown, David A.

Will general purpose unmanned aerial vehicles, (UAVs), best meet the requirements of the twenty-first century battlefield? Although much of the information is speculative of future progress in this...

Optimized Discretization of Sources Imaged in Heavy-Ion Reactions (1997)

Brown, David A., Danielewicz, Pawel

We develop the new method of optimized discretization for imaging the relative source from two particle correlation functions. In this method, the source resolution depends on the relative particle...

Imaging of Sources in Heavy-Ion Reactions (1997)

Brown, David A., Danielewicz, Pawel

Imaging of sources from data within the intensity interferometry is discussed. In the two-pion case, the relative pion source function may be determined through the Fourier transformation of the...

Ribozyme-mediated RNA degradation in nuclei suspension (1995)

Heidenreich, Olaf, Kang, Shin-Heh, Brown, David A., Xu, Xiao, Swiderski, Piotr, Rossi, John J., ...

Ribozymes containing 2′-fluoro- and 2′-amlno-modifled pyrimidine nucleosldes in combination with terminal phosphorothioate linkages were targeted against HTLV-I tax RNA. In oder to examine the...

A history of the men's intramural program at Brigham Young University /--by David A. Brown. (1988)

Brown, David A.

Thesis (M.A.)--Brigham Young University. Dept. of Recreation Management and Youth Leadership.

A history of the men's intramural program at Brigham Young University (1988)

Brown, David A.

Thesis (M.A.)--Brigham Young University. Dept. of Recreation Management and Youth Leadership.

A history of the men's intramural program at Brigham Young University (1988)

Brown, David A.

Thesis (M.A.)--Brigham Young University. Dept. of Recreation Management and Youth Leadership.

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

Two Naturally Occurring Nuclear Polyhedrosis Virus Variants of Neodiprion sertifer Geoffr. (Hymenoptera; Diprionidae)

Brown, David A.

Two isolates of Neodiprion sertifer (Geoffr.) nuclear polyhedrosis virus from Britain and North America were compared using three biochemical techniques. Alkaline protease assays of polyhedra...

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1

Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., ...

Macrophage inhibitory cytokine (MIC-1), a divergent member of the transforming growth factor-β (TGF-β) superfamily and activation associated cytokine, is secreted as a 28 kDa dimer. To understand...

Susceptibility of the heart to ischaemia–reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat

Brown, David A, Lynch, Joshua M, Armstrong, Casey J, Caruso, Nicholas M, Ehlers, Lindsay B, Johnson, Micah S, ...

The cardioprotective effects of short-term exercise against myocardial ischaemia–reperfusion injury in male and female rats were examined. We subjected male and female rats to 0 (Sed; n = 8 males...

Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

Brown, David A, Chicco, Adam J, Jew, Korinne N, Johnson, Micah S, Lynch, Joshua M, Watson, Peter A, ...

This study was conducted to examine the role of myocardial ATP-sensitive potassium (KATP) channels in exercise-induced protection from ischaemia–reperfusion (I–R) injury. Female rats were either...

Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum

Welsh, John B., Sapinoso, Lisa M., Kern, Suzanne G., Brown, David A., Liu, Tao, Bauskin, Asne R., ...

Genetic alterations in tumor cells often lead to the emergence of growth-stimulatory autocrine and paracrine signals, involving overexpression of secreted peptide growth factors, cytokines, and...

Two Naturally Occurring Nuclear Polyhedrosis Virus Variants of Neodiprion sertifer Geoffr. (Hymenoptera; Diprionidae)

Brown, David A.

Two isolates of Neodiprion sertifer (Geoffr.) nuclear polyhedrosis virus from Britain and North America were compared using three biochemical techniques. Alkaline protease assays of polyhedra...

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1

Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., ...

Macrophage inhibitory cytokine (MIC-1), a divergent member of the transforming growth factor-β (TGF-β) superfamily and activation associated cytokine, is secreted as a 28 kDa dimer. To understand...

Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat

Brown, David A, Chicco, Adam J, Jew, Korinne N, Johnson, Micah S, Lynch, Joshua M, Watson, Peter A, ...

This study was conducted to examine the role of myocardial ATP-sensitive potassium (KATP) channels in exercise-induced protection from ischaemia–reperfusion (I–R) injury. Female rats were either...

Susceptibility of the heart to ischaemia–reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat

Brown, David A, Lynch, Joshua M, Armstrong, Casey J, Caruso, Nicholas M, Ehlers, Lindsay B, Johnson, Micah S, ...

The cardioprotective effects of short-term exercise against myocardial ischaemia–reperfusion injury in male and female rats were examined. We subjected male and female rats to 0 (Sed; n = 8 males...

Exercise increases SOCS-3 expression in rat skeletal muscle: potential relationship to IL-6 expression

Spangenburg, Espen E, Brown, David A, Johnson, Micah S, Moore, Russell L

Suppressor of cytokine signalling-3 (SOCS-3) has been implicated in the onset of insulin resistance in non-muscle tissue. Thus, we examined the effects of exercise training on SOCS-3 expression and...

Dual coupling of heterologously-expressed rat P2Y6 nucleotide receptors to N-type Ca2+ and M-type K+ currents in rat sympathetic neurones

Filippov, Alexander K, Webb, Tania E, Barnard, Eric A, Brown, David A

The P2Y6 receptor is a uridine nucleotide-specific G protein-linked receptor previously reported to stimulate the phosphoinositide (PI) pathway. We have investigated its effect in neurones, by...

The P2Y1 receptor closes the N-type Ca2+ channel in neurones, with both adenosine triphosphates and diphosphates as potent agonists

Filippov, Alexander K, Brown, David A, Barnard, Eric A

The rat P2Y1 nucleotide receptor, the P2Y subtype abundant in the brain, was heterologously expressed in rat superior cervical ganglion neurones by micro-injection of the receptor cRNA or cDNA. ADP...

Coupling of the nucleotide P2Y4 receptor to neuronal ion channels

Filippov, Alexander K, Simon, Joseph, Barnard, Eric A, Brown, David A

G protein-linked P2Y nucleotide receptors are known commonly to stimulate the phosphoinositide signalling pathway. However, we have previously demonstrated that the cloned P2Y2, P2Y6 and P2Y1...

Acetylcholine

Brown, David A

This article traces the development of knowledge about the physiology and pharmacology of acetylcholine and its receptors between 1930 and 2005, with emphasis on contributions by members of the...

On the role of endogenous G-protein βγ subunits in N-type Ca2+ current inhibition by neurotransmitters in rat sympathetic neurones

Delmas, Patrick, Brown, David A, Dayrell, Mariza, Abogadie, Fe C, Caulfield, Malcolm P, Buckley, Noel J

Using whole-cell and perforated-patch recordings, we have examined the part played by endogenous G-protein βγ subunits in neurotransmitter-mediated inhibition of N-type Ca2+ channel current ICa) in...

Selective activation of heterologously expressed G protein-gated K+ channels by M2 muscarinic receptors in rat sympathetic neurones

Fernandez-Fernandez, Jose M, Wanaverbecq, Nicolas, Halley, Pam, Caulfield, Malcolm P, Brown, David A

G protein-regulated inward rectifier K+ (GIRK) channels were over-expressed in dissociated rat superior cervical sympathetic (SCG) neurones by co-transfecting green fluorescent protein (GFP)-, GIRK1-...

βγ dimers derived from Go and Gi proteins contribute different components of adrenergic inhibition of Ca2+ channels in rat sympathetic neurones

Delmas, Patrick, Abogadie, Fe C, Milligan, Graeme, Buckley, Noel J, Brown, David A

Using perforated-patch recordings, we have examined the part played by endogenous G-protein subunits in the α2-adrenoceptor-mediated inhibition of N-type Ca2+ currents in sympathetic neurones.Two...

Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents

Pan, Zongming, Selyanko, Alexander A, Hadley, Jennifer K, Brown, David A, Dixon, Jane E, McKinnon, David

The region of alternative splicing in the KCNQ2 potassium channel gene was determined by RNase protection analysis of KCNQ2 mRNA transcripts.Systematic analysis of KCNQ2 alternative splice variant...

Technological and organizational influences on the adoption of activity-based costing in Australia

David A. Brown, Peter Booth, Francesco Giacobbe

The present paper examines one set of potential reasons for the paradox as to why so few firms have adopted activity-based costing (ABC) despite the demonstrated benefits of this costing system. A...

Regulation of M(Kv7.2/7.3) channels in neurons by PIP2 and products of PIP2 hydrolysis: significance for receptor-mediated inhibition

Brown, David A, Hughes, Simon A, Marsh, Stephen J, Tinker, Andrew

M-channels are voltage-gated K+ channels that regulate the excitability of many neurons. They are composed of Kv7 (KCNQ) family subunits, usually Kv7.2 + Kv7.3. Native M-channels and expressed Kv7.2...

Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons

Shah, Mala M., Migliore, Michele, Valencia, Ignacio, Cooper, Edward C., Brown, David A.

Members of the Kv7 family (Kv7.2–Kv7.5) generate a subthreshold K+ current, the M− current. This regulates the excitability of many peripheral and central neurons. Recent evidence shows that...