Oliver Medvedik, Dudley W. Lamming, Keyman D. Kim, David A. Sinclair
Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin...
The role of protein arginine methylation in the formation of silent chromatin (2006)
Yu, Michael C., Lamming, Dudley W., Eskin, Julian A., Sinclair, David A., Silver, Pamela A.
Establishment and maintenance of silent chromatin in the Saccharomyces cerevisiae involves a step-wise assembly of the SIR complex. Here we demonstrate a role for the protein arginine...
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
Cohen, Haim, Sinclair, David A.
The Saccharomyces cerevisiae SGS1 gene encodes a RecQ-like DNA helicase, human homologues of which are implicated in the genetic instability disorders, Bloom syndrome (BS), Rothmund-Thomson syndrome...
Bitterman, Kevin J., Medvedik, Oliver, Sinclair, David A.
When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had...
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
Cohen, Haim, Sinclair, David A.
The Saccharomyces cerevisiae SGS1 gene encodes a RecQ-like DNA helicase, human homologues of which are implicated in the genetic instability disorders, Bloom syndrome (BS), Rothmund-Thomson syndrome...
Bitterman, Kevin J., Medvedik, Oliver, Sinclair, David A.
When it was first proposed that the budding yeast Saccharomyces cerevisiae might serve as a model for human aging in 1959, the suggestion was met with considerable skepticism. Although yeast had...
The role of protein arginine methylation in the formation of silent chromatin
Yu, Michael C., Lamming, Dudley W., Eskin, Julian A., Sinclair, David A., Silver, Pamela A.
Establishment and maintenance of silent chromatin in the Saccharomyces cerevisiae involves a step-wise assembly of the SIR complex. Here we demonstrate a role for the protein arginine...
Medvedik, Oliver, Lamming, Dudley W, Kim, Keyman D, Sinclair, David A
Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin...
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
Firestein, Ron, Blander, Gil, Michan, Shaday, Oberdoerffer, Philipp, Ogino, Shuji, Campbell, Jennifer, ...
Numerous longevity genes have been discovered in model organisms and altering their function results in prolonged lifespan. In mammals, some have speculated that any health benefits derived from...
Kim, Dohoon, Nguyen, Minh Dang, Dobbin, Matthew M, Fischer, Andre, Sananbenesi, Farahnaz, Rodgers, Joseph T, ...
A progressive loss of neurons with age underlies a variety of debilitating neurological disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), yet few effective...