Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
Brüning, Jens C., Gillette, Jennifer A., Zhao, Yi, Bjorbaeck, Christian, Kotzka, Jörg, Knebel, Birgit, ...
Ribosomal subunit kinases (Rsk) have been implicated in the regulation of transcription by phosphorylating and thereby activating numerous transcription factors, such as c-Fos, cAMP responsive...
Dufresne, Scott D., Bjørbæk, Christian, El-Haschimi, Karim, Zhao, Yi, Aschenbach, William G., Moller, David E., ...
The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for the extracellular signal-regulated kinase (ERK), is involved in transcriptional regulation, and one isoform (RSK2) has been implicated in...
Ziouzenkova, Ouliana, Perrey, Stephane, Asatryan, Liana, Hwang, Juliana, MacNaul, Karen L., Moller, David E., ...
Increased levels of triglyceride-rich lipoproteins provoke lipid accumulation in the artery wall, triggering early inflammatory responses central to atherosclerosis like endothelial adhesion molecule...
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
Conarello, Stacey L., Li, Zhihua, Ronan, John, Roy, Ranabir Sinha, Zhu, Lan, Jiang, Guoqiang, ...
Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone, glucagon-like...
Role of AMP-activated protein kinase in mechanism of metformin action
Zhou, Gaochao, Myers, Robert, Li, Ying, Chen, Yuli, Shen, Xiaolan, Fenyk-Melody, Judy, ...
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Inui, Ken-ichi, Moller, David E., Tillotson, Loyal G., Isselbacher, Kurt J.
Membrane vesicles isolated from nontransformed BALB/c 3T3 mouse fibroblasts (3T3) and from those cells transformed by simian virus 40 (SV3T3) displayed carrier-mediated and stereospecific uptake of...
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator.
Ding, Victor D H, Qureshi, Sajjad A, Szalkowski, Deborah, Li, Zhihua, Biazzo-Ashnault, Dawn E, Xie, Dan, ...
Insulin regulates cellular metabolism and growth through activation of insulin receptors (IRs). We recently identified a non-peptide small-molecule IR activator (compound 2), which induced human IR...
Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c-Fos gene
Brüning, Jens C., Gillette, Jennifer A., Zhao, Yi, Bjorbaeck, Christian, Kotzka, Jörg, Knebel, Birgit, ...
Ribosomal subunit kinases (Rsk) have been implicated in the regulation of transcription by phosphorylating and thereby activating numerous transcription factors, such as c-Fos, cAMP responsive...
Dufresne, Scott D., Bjørbæk, Christian, El-Haschimi, Karim, Zhao, Yi, Aschenbach, William G., Moller, David E., ...
The p90 ribosomal S6 kinase (RSK), a cytosolic substrate for the extracellular signal-regulated kinase (ERK), is involved in transcriptional regulation, and one isoform (RSK2) has been implicated in...
Ziouzenkova, Ouliana, Perrey, Stephane, Asatryan, Liana, Hwang, Juliana, MacNaul, Karen L., Moller, David E., ...
Increased levels of triglyceride-rich lipoproteins provoke lipid accumulation in the artery wall, triggering early inflammatory responses central to atherosclerosis like endothelial adhesion molecule...
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
Conarello, Stacey L., Li, Zhihua, Ronan, John, Roy, Ranabir Sinha, Zhu, Lan, Jiang, Guoqiang, ...
Dipeptidyl peptidase IV (DP-IV), a member of the prolyl oligopeptidase family of peptidases, is involved in the metabolic inactivation of a glucose-dependent insulinotropic hormone, glucagon-like...
Role of AMP-activated protein kinase in mechanism of metformin action
Zhou, Gaochao, Myers, Robert, Li, Ying, Chen, Yuli, Shen, Xiaolan, Fenyk-Melody, Judy, ...
Metformin is a widely used drug for treatment of type 2 diabetes with no defined cellular mechanism of action. Its glucose-lowering effect results from decreased hepatic glucose production and...
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ
Lim, Hyunjung, Gupta, Rajnish A., Ma, Wen-ge, Paria, Bibhash C., Moller, David E., Morrow, Jason D., ...
We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate-limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization....
Inui, Ken-ichi, Moller, David E., Tillotson, Loyal G., Isselbacher, Kurt J.
Membrane vesicles isolated from nontransformed BALB/c 3T3 mouse fibroblasts (3T3) and from those cells transformed by simian virus 40 (SV3T3) displayed carrier-mediated and stereospecific uptake of...
Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator.
Ding, Victor D H, Qureshi, Sajjad A, Szalkowski, Deborah, Li, Zhihua, Biazzo-Ashnault, Dawn E, Xie, Dan, ...
Insulin regulates cellular metabolism and growth through activation of insulin receptors (IRs). We recently identified a non-peptide small-molecule IR activator (compound 2), which induced human IR...
AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase*
Chen, Yan Qun, Kuo, Ming-Shang, Li, Shuyu, Bui, Hai H., Peake, David A., Sanders, Philip E., ...
AGPAT6 is a member of the 1-acylglycerol-3-phosphate O-acyltransferase (AGPAT) family that appears to be important in triglyceride biosynthesis in several tissues, but the precise biochemical...