Increased nuchal translucency is associated with jugular lymphatic distension (2002)
Haak, Monique C., Bartelings, Margot M., Jackson, David G., Webb, Sandra
BACKGROUND: Measurement of nuchal translucency (NT) is a widely used method of screening for chromosomal abnormalities. Increased NT is seen in a diversity of fetal malformations. The mechanism...
CD44 isoform expression mediated by alternative splicing: tissue-specific regulation in mice (1994)
Hirano, Hiroyuki, Screaton, Gran R., Bell, Martyn V., Jackson, David G., Bell, John J., Hodes, Richard J.
CD44 is a widely distributed cell surface glycoproteln which shows heterogeneity in molecular expression as a result of post-translatlonal modification as well as alternative splicing of CD44 mRNA....
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, Jeffrey T., Harvey, Natasha, Detmar, Michael, Lagutina, Irina, Grosveld, Gerard, Gunn, Michael D., ...
The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox...
Molecular characterization of lymphatic endothelial cells
Podgrabinska, Simona, Braun, Pascal, Velasco, Paula, Kloos, Bryan, Pepper, Michael S., Jackson, David G., ...
The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins and is an important entry point for leukocytes and tumor cells. Specialized functions...
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
Mandriota, Stefano J., Jussila, Lotta, Jeltsch, Michael, Compagni, Amelia, Baetens, Danielle, Prevo, Remko, ...
Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary...
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
Yoon, Young-sup, Murayama, Toshinori, Gravereaux, Edwin, Tkebuchava, Tengiz, Silver, Marcy, Curry, Cynthia, ...
Although lymphedema is a common clinical condition, treatment for this disabling condition remains limited and largely ineffective. Recently, it has been reported that overexpression of VEGF-C...
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Baluk, Peter, Tammela, Tuomas, Ator, Erin, Lyubynska, Natalya, Achen, Marc G., Hicklin, Daniel J., ...
Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent...
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Maruyama, Kazuichi, Ii, Masaaki, Cursiefen, Claus, Jackson, David G., Keino, Hiroshi, Tomita, Minoru, ...
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved...
An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype
Wigle, Jeffrey T., Harvey, Natasha, Detmar, Michael, Lagutina, Irina, Grosveld, Gerard, Gunn, Michael D., ...
The process of angiogenesis has been well documented, but little is known about the biology of lymphatic endothelial cells and the molecular mechanisms controlling lymphangiogenesis. The homeobox...
Molecular characterization of lymphatic endothelial cells
Podgrabinska, Simona, Braun, Pascal, Velasco, Paula, Kloos, Bryan, Pepper, Michael S., Jackson, David G., ...
The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins and is an important entry point for leukocytes and tumor cells. Specialized functions...
Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis
Mandriota, Stefano J., Jussila, Lotta, Jeltsch, Michael, Compagni, Amelia, Baetens, Danielle, Prevo, Remko, ...
Metastasis is a frequent and lethal complication of cancer. Vascular endothelial growth factor-C (VEGF-C) is a recently described lymphangiogenic factor. Increased expression of VEGF-C in primary...
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema
Yoon, Young-sup, Murayama, Toshinori, Gravereaux, Edwin, Tkebuchava, Tengiz, Silver, Marcy, Curry, Cynthia, ...
Although lymphedema is a common clinical condition, treatment for this disabling condition remains limited and largely ineffective. Recently, it has been reported that overexpression of VEGF-C...
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
Baluk, Peter, Tammela, Tuomas, Ator, Erin, Lyubynska, Natalya, Achen, Marc G., Hicklin, Daniel J., ...
Edema occurs in asthma and other inflammatory diseases when the rate of plasma leakage from blood vessels exceeds the drainage through lymphatic vessels and other routes. It is unclear to what extent...
Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages
Maruyama, Kazuichi, Ii, Masaaki, Cursiefen, Claus, Jackson, David G., Keino, Hiroshi, Tomita, Minoru, ...
In the inflamed cornea, there is a parallel outgrowth of blood and lymphatic vessels into the normally avascular cornea. We tested whether adaptive and/or innate immune cells were actively involved...
Schacht, Vivien, Dadras, Soheil S., Johnson, Louise A., Jackson, David G., Hong, Young-Kwon, Detmar, Michael
The mucin-type glycoprotein podoplanin is specifically expressed by lymphatic but not blood vascular endothelial cells in culture and in tumor-associated lymphangiogenesis, and podoplanin deficiency...
Engering, Anneke, Van Vliet, Sandra J., Hebeda, Konnie, Jackson, David G., Prevo, Remko, Singh, Satwinder K., ...
In the paracortex of lymph nodes, cellular immune responses are generated against antigens captured in peripheral tissues by dendritic cells (DCs). DC-SIGN (dendritic cell-specific ICAM-3 grabbing...
Gale, Nicholas W., Prevo, Remko, Espinosa, Jorge, Ferguson, David J., Dominguez, Melissa G., Yancopoulos, George D., ...
The hyaluronan receptor LYVE-1 is expressed abundantly on the surfaces of lymphatic vessels and lymph node sinus endothelial cells from early development, where it has been suggested to function both...
Grant, Allister J., Goddard, Sarah, Ahmed-Choudhury, Jalal, Reynolds, Gary, Jackson, David G., Briskin, Michael, ...
The chronic inflammatory liver disease primary sclerosing cholangitis (PSC) is associated with portal inflammation and the development of neolymphoid tissue in the liver. More than 70% of patients...
Dadras, Soheil S., Paul, Thomas, Bertoncini, Jennifer, Brown, Lawrence F., Muzikansky, Alona, Jackson, David G., ...
Malignant melanomas of the skin are distinguished by their propensity for early metastatic spread via lymphatic vessels to regional lymph nodes, and lymph node metastasis is a major determinant for...
An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson, Louise A., Clasper, Steven, Holt, Andrew P., Lalor, Patricia F., Baban, Dilair, Jackson, David G.
The exit of antigen-presenting cells and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such an exit is achieved and how...
Manzo, Antonio, Bugatti, Serena, Caporali, Roberto, Prevo, Remko, Jackson, David G., Uguccioni, Mariagrazia, ...
CCL21 is a homeostatic lymphoid chemokine instrumental in the recruitment and organization of T cells and dendritic cells into lymphoid T areas. In human secondary lymphoid organs (SLOs), CCL21 is...
LYVE-1, a New Homologue of the CD44 Glycoprotein, Is a Lymph-specific Receptor for Hyaluronan
Banerji, Suneale, Ni, Jian, Wang, Shu-Xia, Clasper, Steven, Su, Jeffrey, Tammi, Raija, ...
The extracellular matrix glycosaminoglycan hyaluronan (HA) is an abundant component of skin and mesenchymal tissues where it facilitates cell migration during wound healing, inflammation, and em-...