Advances in Brief Power Law Distribution of Chromosome Aberrations in Cancer 1 (2008)
Attila Frigyesi, David Gisselsson, Felix Mitelman, Mattias Höglund
Cancer cells are characterized by having aberrant chromosomes. The number of aberrations and the specific chromosomes affected are correlated with tumor progression. We show that for breast,...
Gisselsson, David, Lundberg, Gisela, Øra, Ingrid, Höglund, Mattias
Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumour of childhood. Several genomic imbalances correlate to prognosis in NB, with structural rearrangements, including...
A case of Cornelia de Lange syndrome from Sudan (2007)
Ellaithi, Mona, Gisselsson, David, Nilsson, Therese, Elagib, Atif, Fadl-Elmula, Imad, Abdelgadir, Mashair
Abstract Background Brachmann de Lange syndrome (BDLS) is a multiple congenital anomaly syndrome characterized by a distinctive facial appearance, prenatal and postnatal growth deficiency,...
Jin, Yuesheng, Stewénius, Ylva, Lindgren, David, Frigyesi, Attila, Calcagnile, Olga, Jonson, Tord, ...
Abstract is not available
Concurrent gain of 17q and the MYC oncogene in a medullomyoblastoma. (2007)
Lindberg, Eva, Persson, Annette, Ora, Ingrid, Mertens, Fredrik, Englund, Elisabet, Gisselsson, David
Abstract is not available
Defective chromosome segregation and telomere dysfunction in aggressive wilms' tumors. (2007)
Stewénius, Ylva, Jin, Yuesheng, Ora, Ingrid, De Kraker, Jan, Bras, Johannes, Frigyesi, Attila, ...
Abstract is not available
Cancer stem cells: Differentiation block or developmental back-tracking? (2006)
Abstract is not available.
Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice (2005)
Petersén, Åsa, Stewénius, Ylva, Björkqvist, Maria, Gisselsson, David
Abstract Background Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. The huntingtin protein expressed from HD has an unknown...
Gisselsson, David, Höglund, Mattias
Abstract is not available
Statistical behavior of complex cancer karyotypes. (2005)
Höglund, Mattias, Frigyesi, Attila, Säll, Torbjörn, Gisselsson, David, Mitelman, Felix
Abstract is not available
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Abstract is not available
Höglund, Mattias, Gisselsson, David, Mandahl, Nils, Mitelman, Felix
Abstract is not available
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, White, Valerie A, Säll, Torbjörn, Mitelman, Felix, ...
Abstract is not available
Wilms tumors develop through two distinct karyotypic pathways. (2004)
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix
Abstract is not available
Statistical analyses of karyotypic complexity in head and neck squamous cell carcinoma. (2004)
Höglund, Mattias, Jin, Charlotte, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix, Mertens, Fredrik
Abstract is not available
Nilsson, Thérèse, Ellaithy, Mona, Ibrahim, Muntaser E, Elmula, Imad Fadl, Gisselsson, David
Abstract is not available
Mitotic instability associated with late genomic changes in bone and soft tissue tumours. (2004)
Gisselsson, David, Pålsson, Eva, Yu, Christina, Mertens, Fredrik, Mandahl, Nils
Abstract is not available
A model for karyotypic evolution in testicular germ cell tumors. (2004)
Frigyesi, Attila, Gisselsson, David, Hansen, Gunnar B, Soller, Maria, Mitelman, Felix, Höglund, Mattias
Abstract is not available
Höglund, Mattias, Gisselsson, David, Soller, Maria, Hansen, Gunnar B, Elfving, Peter, Mitelman, Felix
Abstract is not available
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Mitelman, Felix
Abstract is not available
Chromosome instability in cancer: how, when, and why? (2003)
Abstract is not available
A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. (2003)
Storlazzi, Clelia Tiziana, Mertens, Fredrik, Mandahl, Nils, Gisselsson, David, Isaksson, Margareth, Gustafson, Pelle, ...
Abstract is not available
Ovarian Carcinoma Develops through Multiple Modes of Chromosomal Evolution. (2003)
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix
Abstract is not available
Power law distribution of chromosome aberrations in cancer. (2003)
Frigyesi, Attila, Gisselsson, David, Mitelman, Felix, Höglund, Mattias
Abstract is not available
Cytogenetic aberrations and their prognostic impact in chondrosarcoma. (2002)
Mandahl, Nils, Gustafson, Pelle, Mertens, Fredrik, Akerman, Måns, Baldetorp, Bo, Gisselsson, David, ...
Chondrosarcoma is the second most common primary malignancy of bone. Cytogenetic data are available from close to 100 cases, including all subtypes of chondrosarcoma. Specific chromosomal...
Differentially amplified chromosome 12 sequences in low- and high-grade osteosarcoma. (2002)
Gisselsson, David, Pålsson, Eva, Höglund, Mattias, Domanski, Henryk, Mertens, Fredrik, Pandis, Nikos, ...
Most osteosarcomas are highly aggressive malignancies characterized by a complex pattern of chromosome abnormalities. However, a subgroup of low-grade, parosteal tumors exhibits a relatively simple...
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix
More than 550 breast adenocarcinomas with clonal chromosomal abnormalities have been reported. Although the aberration pattern is clearly nonrandom, no specific primary or secondary karyotypic...
Coping with complexity. multivariate analysis of tumor karyotypes. (2002)
Höglund, Mattias, Gisselsson, David, Säll, Torbjörn, Mitelman, Felix
Human cancers are characterized by chromosomal aberrations, and an increasing number of specific balanced rearrangements have been found among malignant hematologic disorders. Most solid tumors,...
Höglund, Mattias, Gisselsson, David, Hansen, Gunnar B, Säll, Torbjörn, Mitelman, Felix, Nilbert, Mef
More than 500 colorectal tumors with clonal chromosomal abnormalities have been reported. Although the pattern of aberrations is nonrandom, no specific primary or secondary karyotypic abnormality has...
Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours (2000)
Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT)...
Chromosomal Instability and Genomic Amplification in Bone and Soft Tissue Tumours (2000)
Acquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT)...
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
Petersén, Åsa, Stewénius, Ylva, Björkqvist, Maria, Gisselsson, David
Limitations of Chromosome Classification by Multicolor Karyotyping
Lee, Charles, Gisselsson, David, Jin, Charlotte, Nordgren, Ann, Ferguson, David O., Blennow, Elisabeth, ...
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al. 1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful...
Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity
Gisselsson, David, Pettersson, Louise, Höglund, Mattias, Heidenblad, Markus, Gorunova, Ludmila, Wiegant, Joop, ...
It has long been known that rearrangements of chromosomes through breakage-fusion-bridge (BFB) cycles may cause variability of phenotypic and genetic traits within a cell population. Because...
Gisselsson, David, Jonson, Tord, Petersén, Åsa, Strömbeck, Bodil, Dal Cin, Paola, Höglund, Mattias, ...
Although mechanisms for chromosomal instability in tumors have been described in animal and in vitro models, little is known about these processes in man. To explore cytogenetic evolution in human...
Stewénius, Ylva, Gorunova, Ludmila, Jonson, Tord, Larsson, Nina, Höglund, Mattias, Mandahl, Nils, ...
Telomere dysfunction has been associated with chromosomal instability in colorectal carcinoma, but the consequences of telomere-dependent instability for chromosome integrity and clonal evolution...
Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
Petersén, Åsa, Stewénius, Ylva, Björkqvist, Maria, Gisselsson, David
Limitations of Chromosome Classification by Multicolor Karyotyping
Lee, Charles, Gisselsson, David, Jin, Charlotte, Nordgren, Ann, Ferguson, David O., Blennow, Elisabeth, ...
Multicolor karyotyping technologies, such as spectral karyotyping (SKY) (Schröck et al. 1996; Liyanage et al. 1996) and multiplex (M-) FISH (Speicher et al. 1996), have proved to be extremely useful...
A case of Cornelia de Lange syndrome from Sudan
Ellaithi, Mona, Gisselsson, David, Nilsson, Therese, Elagib, Atif, Fadl-Elmula, Imad, Abdelgadir, Mashair
Gisselsson, David, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Mandahl, Nils
Hibernomas are benign tumors of brown fat, frequently characterized by aberrations of chromosome band 11q13. In this study, the chromosome 11 changes in five hibernomas were analyzed in detail by...
Abnormal Nuclear Shape in Solid Tumors Reflects Mitotic Instability
Gisselsson, David, Björk, Jonas, Höglund, Mattias, Mertens, Fredrik, Dal Cin, Paola, Åkerman, Måns, ...
Abnormalities in nuclear morphology are frequently observed in malignant tissues but the mechanisms behind these phenomena are still poorly understood. In this study, the relation between abnormal...
Gisselsson, David, Hibbard, Michele K., Dal Cin, Paola, Sciot, Raf, Hsi, Bae-Li, Kozakewich, Harry P., ...
Lipoblastomas are rare soft tissue tumors that occur primarily in young children. They typically contain variably differentiated adipocytes, primitive mesenchymal cells, myxoid matrix, and fibrous...
Distinct evolutionary mechanisms for genomic imbalances in high-risk and low-risk neuroblastomas
Gisselsson, David, Lundberg, Gisela, Øra, Ingrid, Höglund, Mattias
Gisselsson, David, Håkanson, Ulf, Stoller, Patrick, Marti, Dominik, Jin, Yuesheng, Rosengren, Anders H., ...
Rebetz, Johan, Tian, Dongping, Persson, Annette, Widegren, Bengt, Salford, Leif G., Englund, Elisabet, ...
Lundberg, Gisela, Rosengren, Anders H., Håkanson, Ulf, Stewénius, Henrik, Jin, Yuesheng, Stewénius, Ylva, ...
Pietras, Alexander, Hansford, Loen M., Johnsson, A. Sofie, Bridges, Esther, Sjölund, Jonas, Gisselsson, David, ...
High hypoxia-inducible factor-2α (HIF-2α) protein levels predict poor outcome in neuroblastoma, and hypoxia dedifferentiates cultured neuroblastoma cells toward a neural crest-like phenotype. Here,...
Bexell, Daniel, Gunnarsson, Salina, Tormin, Ariane, Darabi, Anna, Gisselsson, David, Roybon, Laurent, ...
Bone marrow–derived multipotent mesenchymal stroma cells (MSCs) have emerged as cellular vectors for gene therapy of solid cancers. We implanted enhanced green fluorescent protein–expressing rat...