Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme (2009)
Eastmond, David A., Hartwig, Andrea, Anderson, Diana, Anwar, Wagida A., Cimino, Michael C., Dobrev, Ivan, ...
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for...
Zienolddiny, Shanbeh, Skaug, Vidar, Landvik, Nina E., Ryberg, David, Phillips, David H., Houlston, Richard, ...
Genome-wide association studies have provided evidence that common variation at 5p15.33 [telomerase reverse transcriptase (TERT)-cleft lip and palate transmembrane 1-like (CLPTM1L)], 6p21.33 and...
Arlt, Volker M., Stiborová, Marie, Henderson, Colin J., Thiemann, Markus, Frei, Eva, Aimová, Dagmar, ...
Many studies using mammalian cellular and subcellular systems have demonstrated that polycyclic aromatic hydrocarbons, including benzo[a]pyrene (BaP), are metabolically activated by cytochrome P450s...
DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis (2008)
Veglia, Fabrizio, Loft, Steffen, Matullo, Giuseppe, Peluso, Marco, Munnia, Armelle, Perera, Frederica, ...
Bulky DNA adducts are biomarkers of exposure to aromatic compounds and of the ability of the individual to metabolically activate carcinogens and to repair DNA damage. Their ability to predict cancer...
Arlt, Volker M., Gingerich, John, Schmeiser, Heinz H., Phillips, David H., Douglas, George R., White, Paul A.
FE1 lung epithelial cells derived from Muta™Mouse are a new model system to provide in vitro mutagenicity data with the potential to predict the outcome of an in vivo Muta™Mouse test....
Bhana, Sara, Hewer, Alan, Phillips, David H., Lloyd, Daniel R.
Cisplatin is an extremely effective chemotherapeutic agent used for the treatment of testicular and other solid tumours. It induces a variety of structural modifications in DNA, the most abundant...
Hockley, Sarah L., Arlt, Volker M., Jahnke, Gunnar, Hartwig, Andrea, Giddings, Ian, Phillips, David H.
Human colon carcinoma cells (HCT116) differing in p53 status were exposed to benzo(a)pyrene (BaP) or anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide (BPDE) and their gene expression responses...
Arlt, Volker M., Stiborová, Marie, Vom Brocke, Jochen, Simões, Maria L., Lord, Graham M., Nortier, Joelle L., ...
Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects at least 25 000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has recently...
Mutagenicity and DNA Adduct Formation by the Urban Air Pollutant 2-Nitrobenzanthrone (2007)
Arlt, Volker M., Glatt, Hansruedi, Gamboa Da Costa, Gonçalo, Reynisson, Jóhannes, Takamura-Enya, Takeji, Phillips, David H.
2-Nitrobenzanthrone (2-NBA) has recently been detected in ambient air particulate matter. Its isomer 3-nitrobenzanthrone (3-NBA) is a potent mutagen and suspected human carcinogen identified in...
Bieler, Christian A., Cornelius, Michael G., Stiborova, Marie, Arlt, Volker M., Wiessler, Manfred, Phillips, David H., ...
Sprague–Dawley rats were treated by intratracheal instillation with a single dose of 0.2 mg/kg body wt of 3-nitrobenzanthrone (3-NBA), and whole blood, lungs, pancreases, kidneys, urinary bladders,...
Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation. (2007)
Jiao, Haiyan, Allinson, Sarah L., Walsh, Michael J., Hewitt, Rebecca, Cole, Kathy J., Phillips, David H., ...
Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation...
Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation (2007)
Jiao, Haiyan, Allinson, Sarah L., Walsh, Michael J., Hewitt, Rebecca, Cole, Kathy J., Phillips, David H., ...
Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation...
Hockley, Sarah L, Arlt, Volker M, Brewer, Daniel, Giddings, Ian, Phillips, David H
Abstract Background The multi-step process of carcinogenesis can be more fully understood by characterizing gene expression changes induced in cells by carcinogens. In this study, expression...
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer (2006)
Zienolddiny, Shanbeh, Campa, Daniele, Lind, Helge, Ryberg, David, Skaug, Vidar, Stangeland, Lodve, ...
Lung cancer is a leading cause of cancer mortality with an inter-individual difference in susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA repair and...
Martin, Francis L., Piearce, Trevor G., Hewer, Alan, Phillips, David H., Semple, Kirk T.
There is a need to develop risk biomarkers during the remediation of contaminated land. We employed the earthworm, Aporrectodea longa (Ude), to determine whether genotoxicity measures could be...
Phillips, David H., Hewer, Alan, Osborne, Martin R., Cole, Kathleen J., Churchill, Cyd, Arlt, Volker M.
Tamoxifen is an anti-oestrogen widely used in the adjuvant therapy of breast cancer and is also used as a prophylactic to prevent the disease in high-risk women. An increased risk of endometrial...
Lebeau, Catherine, Debelle, Frédéric D., Arlt, Volker M., Pozdzik, Agnieszka, De Prez, Eric G., Phillips, David H., ...
Background. Aristolochic acid (AA), the plant extract of Aristolochia species, is involved in the onset of progressive tubulointerstitial renal fibrosis in humans. Clinical and in vitro findings have...
Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods (2005)
Schild, Laura J., Phillips, David H., Osborne, Martin R., Hewer, Alan, Beland, Frederick A., Churchwell, Mona I., ...
Liver homogenates from rats fed tamoxifen (TAM) in the diet were shared among four different laboratories. TAM–DNA adducts were assayed by high pressure liquid chromatography–electrospray tandem...
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer (2005)
Zienolddiny, Shanbeh, Campa, Daniele, Lind, Helge, Ryberg, David, Skaug, Vidar, Stangeland, Lodve, ...
Lung cancer is a leading cause of cancer mortality with an interindividual difference in susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA repair and...
Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods (2005)
Schild, Laura J., Phillips, David H., Osborne, Martin R., Hewer, Alan, Beland, Frederick A., Churchwell, Mona I., ...
Liver homogenates from rats fed tamoxifen (TAM) in the diet were shared among four different laboratories. TAM-DNA adducts were assayed by high pressure liquid chromatography-electrospray tandem mass...
Phillips, David H., Hewer, Alan, Osborne, Martin R., Cole, Kathleen J., Churchill, Cyd, Arlt, Volker M.
Tamoxifen is an anti-oestrogen widely used in the adjuvant therapy of breast cancer and is also used as a prophylactic to prevent the disease in high-risk women. An increased risk of endometrial...
Lebeau, Catherine, Debelle, Frédéric D., Arlt, Volker M., Pozdzik, Agnieszka, De Prez, Eric G., Phillips, David H., ...
Background. Aristolochic acid (AA), the plant extract of Aristolochia species, is involved in the onset of progressive tubulointerstitial renal fibrosis in humans. Clinical and in vitro findings have...
Donnelly, Eilish T., Bardwell, Helen, Thomas, Geraldine Anne, Williams, E. Dillwyn, Hoper, Margaret, Crowe, Paul, ...
Red meat consumption is associated with endogenous metabolic generation of mutagenic N-nitroso compounds (NOC) and may be implicated in causation of colorectal cancer. Assessment of a biologically...
Donnelly, Eilish T., Bardwell, Helen, Thomas, Geraldine Anne, Williams, E. Dillwyn, Hoper, Margaret, Crowe, Paul, ...
Red meat consumption is associated with endogenous metabolic generation of mutagenic N-nitroso compounds (NOC) and may be implicated in causation of colorectal cancer (CRC). Assessment of a...
Arlt, Volker M., Cole, Kathleen J., Phillips, David H.
3‐Nitrobenzanthrone (3‐NBA) is one of the most potent mutagens in the Ames Salmonella typhimurium assay and a suspected human carcinogen recently identified in diesel exhaust and in...
Beland, Frederick A., Churchwell, Mona I., Doerge, Daniel R., Parkin, Daniel R., Malejka-Giganti, Danuta, Hewer, Alan, ...
Background: Although the nonsteroidal antiestrogen tamoxifen is used as an adjuvant chemotherapeutic agent to treat hormone-dependent breast cancer and as a chemopreventive agent in women with...
Arlt, Volker M., Glatt, Hansruedi, Muckel, Eva, Pabel, Ulrike, Sorg, Bernd L., Schmeiser, Heinz H., ...
3-Nitrobenzanthrone (3-NBA) an extremely potent mutagen and suspected human carcinogen identified in diesel exhaust and in airborne particulate matter was shown to form multiple DNA adducts in vitro...
Perera, Frederica P., Mooney, LaVerne A., Stampfer, Meir, Phillips, David H., Bell, Douglas A., Rundle, Andrew, ...
DNA damage from polycyclic aromatic hydrocarbons (PAH) and other aromatic/hydrophobic compounds has been implicated in case–control studies as a risk factor for lung cancer, as have common...
Pfau, Wolfgang, Martin, Francis L., Cole, Kathleen J., Weaver, Gillian, Marquardt, Hans, Phillips, David H., ...
Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk...
Genotoxicity of human breast milk from different countries. (2001)
Martin, Francis L., Cole, Kathleen J., Weaver, Gillian, Hong, Ga S., Lam, Barbara C., Balaram, Prabha, ...
Dietary and/or environmental factors appear to play a key role in the international variations that exist in breast cancer incidence. The genotoxicity of breast milk extracts is being examined as a...
Genotoxicity of human breast milk from different countries. (2001)
Phillips, David H., Martin, Francis L., Grover, Philip L., Cole, Kathleen J., Weaver, Gillian, Hong, Ga S., ...
Mechanisms of carcinogenicity and DNA adduct formation by tamoxifen. (2001)
Phillips, David H., Martin, Francis L., Hewer, A., Osborne, M. R.
Understanding the genotoxicity of tamoxifen? (2001)
Tamoxifen is an anti-oestrogenic drug widely used for adjuvant therapy of breast cancer. Its use has caused an increased incidence of endometrial cancer and it is also a potent carcinogen in rat...
Genotoxicity of human breast milk from different countries (2001)
Martin, Francis L., Cole, Kathleen J., Weaver, Gillian, Hong, Ga S., Lam, Barbara C., Balaram, Prabha, ...
Dietary and/or environmental factors appear to play a key role in the international variations that exist in breast cancer incidence. The genotoxicity of breast milk extracts is being examined as a...
The influence of dietary and environmental factors on prostate cancer risk. (2000)
Kooiman, G., Martin, Francis L., Williams, J. A., Grover, Philip L., Phillips, David H., Muir, Gordon H.
Prostate cancer is the most common malignancy found in males and one of the most common causes of cancer death. The epidemiology implicates environmental and nutritional factors in the initiation and...
Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells. (2000)
Martin, Francis L., Cole, K. J., Williams, J. A., Millar, B. C., Harvey, D. R., Weaver, Gillian, ...
Exfoliated cells, isolated from breast milk samples donated by UK-resident women (n=15), were incubated, either immediately or after culture for 7 days, with one of a series of genotoxins, either in...
Khan, Q. M., Phillips, David H., Martin, Francis L., Hewer, A., Cole, Kathleen J., Hussain, I. H., ...
Martin, Francis L., Williams, J. A., Cole, Kathleen J., Muir, Gordon H., Grover, Philip L., Phillips, David H.
Williams, J. A., Martin, Francis L., Muir, Gordon H., Grover, Philip L., Phillips, David H.
Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic...
DNA damage in breast milk cells and its induction by "early" and "late" milk extracts. (2000)
Martin, Francis L., Cole, Kathleen J., Harvey, D. R., Weaver, Gillian, Williams, J. A., Millar, B. C., ...
Environmental and dietary factors are thought to be significant in breast cancer aetiology. The alkaline single-cell gel electrophoresis (‘Comet’) assay was used to examine breast milk cells for...
DNA damage in human breast milk cells and induction by milk extracts. (2000)
Martin, Francis L., Cole, Kathleen J., Williams, J. A., Millar, B. C., Phillips, David H., Grover, Philip L.
Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients (2000)
Bartsch, Helmut, Phillips, David H., Nair, Jagadeesan, Hewer, Alan, Meyberg-Solomeyer, Gabriele, Grischke, Eva-Maria
Tamoxifen (TAM) is used for the adjuvant treatment of women with breast cancer and has also been recommended as a chemopreventive agent. Among unwanted side effects, TAM was shown to increase...
Williams, J.Andrew, Stone, Elaine M., Millar, Barbara C., Hewer, Alan, Phillips, David H.
Most human mammary carcinomas originate in the epithelial cells of the breast ducts. A potential role of heterocyclic amines (HAs) in the aetiology of this disease has led us to investigate...
Sattar, Abid, Hewer, Alan, Phillips, David H., Campbell, Frederick C.
Tumour formation may involve interactions between genetic factors and environmental carcinogens. Adenoma formation in APCMin/+ mice is associated homozygous adenomatous polyposis coli (APC) gene...
Heterocyclic aromatic amines induce DNA strand breaks and cell transformation (1999)
Pfau, Wolfgang, Martin, Francis L., Cole, Kathleen J., Venitt, Stanley, Phillips, David H., Grover, Philip L., ...
Heterocyclic aromatic amines (HAAs), formed during the cooking of foods, are known to induce tumours in rodent bioassays and may thus contribute to human cancer risk. We tested six HAAs in a...
Osborne, Martin R., Hewer, Alan, Davis, Warren, Strain, Alastair J., Keogh, Adrian, Hardcastle, Ian R., ...
The drug tamoxifen shows evidence of genotoxicity, and induces liver tumours in rats. Covalent DNA adducts have been detected in the liver of rats treated with tamoxifen, and these arise through...
Carmichael, Paul L., Sardar, Shahida, Crooks, Neil, Neven, Patrick, Van Hoof, Ingrid, Ugwumadu, Austin, ...
Tamoxifen is associated with an increased incidence of endometrial cancer in women. It is also a potent carcinogen in rat liver and forms covalent DNA adducts in this tissue. A previous study...
Remote Time Transfer System with Epoch Pulse. (1998)
Phillips,David H., Phillips,Ruth E.
The patent describes a passive method and equipment for synchronizing time systems, atomic or precision clocks, by transferring both time and frequency information. The time and frequency information...
NDE X-Ray Computed Tomography Applications Research. (1998)
Neel, S. T., Yancey, Robert N., Eliasen, Dennis S., Phillips, David H.
This report summarizes research efforts in X-ray computed tomography at Wright Laboratory. Attention is focused on applications development efforts that have been successful in coupling CT with...
X-ray Computed Tomography for the Testing and Evaluation of Ceramic Processes. (1998)
Phillips, David H., Lannutti, John J.
X-ray computed tomography (CT), a nondestructive evaluation technique, generates high-resolution, three-dimensional density profiles of geometrically complex objects. One use of CT is characterizing...
Carmichael, Paul L., Stone, Elaine M., Grover, Phillip L., Gusterson, Barry A., Phillips, David H.
Cultures of human mammary epithelial cells were treated with one of seven heterocyclic amine food mutagens [2-amino-3-methylimidazo[4, 5-f)quinoline (IQ), 2-amino-3, 4-dimethylimidazo[4,...
p53mutations in lung tumours: relationship to gender and lung DNA adduct levels (1996)
Kure, Elin H., Ryberg, David, Hewer, Alan, Phillips, David H., Skaug, Vidar, Bæera, Rita, ...
Human lung cancer exhibits a high frequency of transver-sion mutations at G: C base pairs of the p53 gene, possibly the result of DNA damage by cigarette smoke constituents, most notably...
Phillips, David H., Carmichael, Paul L., Hewer, Alan, Cole, Kathleen J., Hardcastle, Ian R., Poon, Grace K., ...
The metabolic activation of tamoxifen and its metabolite α-hydroxytamoxifen in primary cultures of rat, mouse and human hepatocytes has been compared. The extent of formation of DNA adducts in these...
Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients (1996)
Phillips, David H., Hewer, Alan, Grover, Philip L., Poon, Grace K., Carmichael, Paul L.
DNA from white blood cells of seven women receiving tamoxifen as adjuvant therapy for breast cancer and of three women who served as healthy controls was analysed for the presence of tamoxifen-DNA...
Phillips, David H., Potter, Gerard A., Horton, Martin N., Hewker, Alan, Crofton-Sleigh, Christopher, Jarman, Michael, ...
A proposed mechanism for the metabolic activation of tamoxifen to electrophilk species that form DNA adducts leading to liver cancer involves α-hydroxylation of the ethyl group in the critical first...
Phillips, David H., Hewer, Alan, White, Ian N. H., Farmer, Peter B.
Tamoxifen is a potent liver carcinogen in rats and has been shown to form covalent DNA adducts in the livers of several species of rodent. We have shown previously by 32P-postlabelling...
Genotoxicity characteristics of reverse diol-epoxides of chrysene (1993)
Glatt, Hansruedi, Wameling, Christa, Elsberg, Sabine, Thomas, Helmut, Marquardt, Hans, Hewer, Alan, ...
Trans-3,4-dihydroxy-3,4-dihydrochrysene (chrysene-3,4-diol), a major metabolite of chrysene, is further metabolized by rat liver enzymes to products which effectively revert the his− Salmonella...
Touati, Eliette, Phillips, David H., Quillardet, Philippe, Hofnung, Maurice
The characterization of target nucleotides involved in the binding to DNA of 7-methoxy-2-nitro-naphtho[2,1–b]furan (R7000), a very potent genotoxic nitrofuran derivative, was investigated. Since...
Carmichael, Paul L., Shé, Meadhbh Ni, Phillips, David H.
Reactive oxygen species can give rise to numerous modifications of DNA. We have investigated the formation of such modifications using the nuclease P1 digestion method of the 32P-postlabelling...
Interaction of omeprazole with DNA in rat tissues (1992)
Phillips, David H., Hewer, Alan, Osborne, Martin R.
There has been concern recently over the possible genotoxicity of omeprazole, a potent inhibitor of gastric acid secretion in humans. In order to investigate its possible DNA binding activity in...
White, Ian N.H., De Matteis, Francesco, Davies, Adrian, Smith, Lewis L., Crofton-Sleigh, Christopher, Venitt, Stanley, ...
Chronic administration of tamoxifen to female rats causes hepatocellular carcinomas. We have investigated damage to liver DNA caused by the administration of tamoxifen to female Fischer F344/N...
Pfau, Wolfgang, O'Hare, Michael J., Grover, Philip L., Phillips, David H.
When incubated in suspension with the heterocyclic aromatic amine food mutagens 2-amino-3-methylimidazo [4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), human mammary...
Grunicke, Hans, Stoeck, Michael, Elsner, J., Seemann, G., Pfeiffer, C., Wegmann, B., ...
Peer Reviewed
Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L (1991)
Poginsky, Barbara, Westendorf, Johannes, Blömeke, Brunhilde, Marquardt, Hans, Hewer, Alan, Grover, Philip L., ...
The naturally-occurring anthraquinones (AQs), alizarin (1,2-dihydroxyanthraquinone) and lucidin (1,3-dihydroxy-2-hydroxymethylanthraquinone), were incubated with DNA in the presence of S9 mix. The...
Lecoq, Sophie, Ni She, Meadhbh, Hewer, Alan, Grover, Philip L., Platt, Karl L., Oesch, Franz, ...
Dibenz[a,h]anthracene (DB[a,h]A) and the related 3,4-diol and anti- and syn-3,4-diol 1,2-oxides were applied to the shaved dorsal skin of groups of four C57B1/CB1 mice. Twenty-four hours later the...
Hall, Michael, Shé, Meadhbh Ni, Wild, Dieter, Fasshauer, Ingrid, Hewer, Alan, Phillips, David H.
Male and female CDF, mice were administered a single oral dose of 3 µmol of the food mutagens 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) or 2-amino-3,4-dimethylimidazo [4,5-f]quinoline (MeIQ) and...
Carmichael, Paul L., Jacob, Jürgen, Grimmer, Gernot, Phillips, David H.
Engine lubricating oils are known to accumulate carcinogenic polycyclic aromatic hydrocarbons (PAHs) during engine running. Oils from nine petrol-powered and 11 diesel-powered vehicles, in addition...
Schoket, Bernadette, Hewer, Alan, Grover, Phillip L., Phillips, David H.
Samples of unused or used petrol and diesel engine lubricating oils were applied to the shaved dorsal skin of 4- to 6-week-old male Parkes mice, either as a single treatment (50 μ/mouse) or as four...
Masento, Mark S., Hewer, Alan, Grover, Philip L., Phillips, David H.
32P-Postlabelling analysis is a sensitive method of detecting covalent modification of DNA by chemical carcinogens. We demonstrate that tetrol derivatives of the polycyclk aromatic hydrocarbons...
Metabolic activation of 7-ethyl- and 7-methylbenz[a]anthracene in mouse skin (1988)
McKay, Simon, Phillips, David H., Hewer, Alan J., Grover, Philip L.
The carcinogen 7-methylbenz[a]anthracene (7-MBA) is considered to be metabolically activated via its bay-region dihydrodiol-epoxide, trans-3,4-dihydro-3,4-dihydroxy-7- methyl-benz[a]anthracene...
Hall, Michael, Parker, Deborah K., Hewer, Alan J., Phillips, David H., Grover, Philip L.
Incubation of r-1t-2-dihydroxy-t-3,4-oxy-1,2,3,4-tetrahydro-chrysene (anti-chrysene-1,2-diol 3,4-oxide), the bay-region diol-epoxide of chrysene, with rat liver microsomes in the presence of NADP+...
Ireland, Christine M., Cooper, Colin S., Marshall, Christopher J., Hebert, Eric, Phillips, David H.
Foci of transformed NIH3T3 cells were observed after transfection of plasmids containing the c-Ha-ras-1 protooncogene modified in vitro either with the 3-N,N-acetoxyacetyl derivative (N-AcO-AGlu-P-3)...
Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes (1986)
Phillips, David H., Hewer, Alan, Grover, Philip L.
DNA from normal human bone marrow mononuclear and non-mononuclear cells was analysed by 32P-post-labelling for the presence of aromatic adducts. Ten out of 10 individuals showed the presence of...
Stanton, Caroline A., Chow, Fong L., Phillips, David H., Grover, Philip L., Garner, R. Colin, Martin, Carl N.
[3H]1-Nitropyrene was administered at a dose of 25 mg/kg by i.p. injection to female Wistar rats. Animals were killed 24h later and DNA was isolated from kidney, liver and mammary gland,...
Randerath, Kurt, Haglund, Roberta E., Phillips, David H., Reddy, M. Vijayaraj
The binding of a series of alkenylbenzenes to liver DNA of adult female CD-1 mice, isolated 24 h after i.p. administration of non-radioactive test compound (2 or 10 mg/mouse), was investigated by...
Phillips, David H., Reddy, M. Vijayaraj, Randerath, Kurt
When a series of nine alkenylbenzenes were administered to preweanling male mice, safrole, estragole and methyleugenol induced a significant incidence of hepatic carcinomas, while eugenol, anethole,...
Phillips, David H., Hanawalt, Philip C.
The response of cultured human cells to treatment with 1′ -acetoxysafrole (1′ -AcO-S) and 1′ -acetoxyestragole (1′ -AcO-E), which are electrophilic and mutagenic, has been examined. Fifty...
Phillips, David H., Hanawalt, Philip C.
The formation and repair of alkali-labile sites in the DNA of human cells treated with 254 nm u.v. light, 1′ -acetoxyestragole (1′ -AcO-E) or 1′ -acetoxysafrole (1′ -AcO-S) have been studied....
Hussain, S. Perwez, Raja, Kamran, Amstad, Paul A., Sawyer, Mark, Trudel, Laura J., Wogan, Gerald N., ...
Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the...
Hussain, S. Perwez, Raja, Kamran, Amstad, Paul A., Sawyer, Mark, Trudel, Laura J., Wogan, Gerald N., ...
Hemochromatosis and Wilson disease (WD), characterized by the excess hepatic deposition of iron and copper, respectively, produce oxidative stress and increase the risk of liver cancer. Because the...