David Holmes

Publication List Details

Period

1981 - 2009

Number

112

Co-Authors

Next generation drug-eluting stents: focus on bioabsorbable platforms and polymers (2009)

Holmes, David

Brendan Doyle, David R Holmes JrDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USAAbstract: The success of drug-eluting...

Guidelines for Implementation of Model Quality Reports (2009)

Mats Bergdahl, Ole Black, Russell Bowater, Susan Full, David Holmes, Pär Lundqvist, ...

description of the methods for assessing the quality of surveys, with particular application in the context of business surveys, and then to apply these methods in some example surveys to evaluate...

The Boeing Company (2009)

Austin Armbruster, Jason Baker, Antonio Cunei, Chapman Flack, David Holmes, Filip Pizlo, ...

This paper reports on our experience with the implementation of the Real-time Specification for Java on the Ovm open source Java virtual machine. We describe the architecture and main design...

Volume I Theory and Methods for Quality Evaluation Preface (2009)

Mats Bergdahl, Ole Black, Russell Bowater, Susan Full, David Holmes, Pär Lundqvist, ...

The Model Quality Report in Business Statistics project was set up to develop a detailed description of the methods for assessing the quality of surveys, with particular application in the context of...

Comparison of Variance Estimation Software and Methods Preface (2008)

Mats Bergdahl, Ole Black, Russell Bowater, Susan Full, David Holmes, Pär Lundqvist, ...

The Model Quality Report in Business Statistics project was set up to develop a detailed description of the methods for assessing the quality of surveys, with particular application in the context of...

Java Language Specification, Third Edition (2008)

Ken Arnold, James Gosling, David Holmes, James Gosling, Bill Joy, Guy Steele, ...

All rights reserved. Duke logo ™ designed by Joe Palrang. RESTRICTED RIGHTS LEGEND: Use, duplication, or disclosure by the United States Government is subject to the restrictions set forth in DFARS...

The Fallacies and Fortunes of 'Interactivity ' in Communication Theory (2008)

David Holmes

The term ‘Interactivity ’ persists as both a buzzword and a fraught concept within communication theory. For 1950s information theorists (e.g. Shannon and Weaver, 1949) interactivity denoted two...

Diffractive micro bar codes for encoding of biomolecules in multiplexed assays. (2008)

Broder, Graham R., Ranasinghe, Rohan T., She, Joseph K., Banu, Shahanara, Birtwell, Sam W., Cavalli, Gabbriel, ...

Microparticles incorporating micrometer-sized diffractive bar codes have been modified with oligonucleotides and immunoglobulin Gs to enable DNA hybridization and immunoassays. The bar codes are...

Java Language Specification, Third Edition (2008)

Ken Arnold, David Holmes, Tim Lindholm, Frank Yellin, Frank Yellin, The Java Team, ...

All rights reserved. Duke logo ™ designed by Joe Palrang. RESTRICTED RIGHTS LEGEND: Use, duplication, or disclosure by the United States Government is subject to the restrictions set forth in DFARS...

Diffractive Micro Bar Codes for Encoding of Biomolecules in Multiplexed Assays. (2008)

Broder, G.R, Ranasinghe , R.T, She, J.K, Banu, Shahanara, Birtwell, Sam, Cavalli , G., ...

Microparticles incorporating micrometer-sized diffractive bar codes have been modified with oligonucleotides and immunoglobulin Gs to enable DNA hybridization and immunoassays. The bar codes are...

1 Using Relevance Feedback within the Relational Model for TREC-5 (2007)

David A. Grossman, Carol Lundquist, John Reichart, David Holmes, Abdur Chowdhury, Ophir Frieder

For TREC-5, we enhanced our existing prototype that implements relevance ranking using the AT&T DBC-1012 Model 4 parallel database machine to include relevance feedback. We identified SQL to...

Formal Specification of a Hard Real-Time Kernel (2007)

Version David Holmes, David Holmes

This report describes the specification and refinement of the core features of a small hard real-time microkernel. Concentrating on the system data structures and the operations to be applied to...

Implementation and Timing Analysis of a Hard Real-Time Microkernel (2007)

David Holmes Academic, David Holmes

, a demonstration application was developed, together with external timing hardware, that allows us to investigate the relationship between scheduling theory and run-time practice. The resulting...

Abstract Improving Precision and Recall for Soundex Retrieval (2007)

David Holmes

We present a phonetic algorithm that fuses existing techniques and introduces new features. This combination offers improved precision and recall. 1

Comparison of Variance Estimation Software and Methods Preface (2007)

Mats Bergdahl, Ole Black, Russell Bowater, Susan Full, David Holmes, Pär Lundqvist, ...

The Model Quality Report in Business Statistics project was set up to develop a detailed description of the methods for assessing the quality of surveys, with particular application in the context of...

Microsoft (2007)

David Holmes, James Noble, John Potter

Aspect Oriented Programming (AOP) allows a programmer to "express the different aspects of a software system in a separate and natural form, and then automatically combine those separate...

Discrimination and analysis of phytoplankton using a microfluidic cytometer (2007)

Benazzi, Giuseppe, Holmes, David, Sun, Tao, Mowlem, Matt, Morgan, Hywel

Identification and analysis of phytoplankton is important for understanding the environmental parameters that are influenced by the oceans, including pollution and climate change. Phytoplanktons are...

Discrimination and analysis of phytoplankton using a microfluidic cytometer (2007)

Benazzi, Giuseppe, Holmes, David, Sun, Tao, Mowlem, Matt, Morgan, Hywel

Identification and analysis of phytoplankton is important for understanding the environmental parameters that are influenced by the oceans, including pollution and climate change. Phytoplanktons are...

Single cell dielectric spectroscopy (2007)

Morgan, Hywel, Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G

Over the last century a number of techniques have been developed which allow the measurement of the dielectric properties of biological particles in fluid suspension. The majority of these techniques...

High speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences (2007)

Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G, Morgan, Hywel

A novel impedance spectroscopy technique has been developed for high speed single biological particle analysis. A microfluidic cytometer is used to measure the impedance of single micrometre sized...

Single cell dielectric spectroscopy (2007)

Morgan, Hywel, Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G

Over the last century a number of techniques have been developed which allow the measurement of the dielectric properties of biological particles in fluid suspension. The majority of these techniques...

Single cell dielectric spectroscopy (2007)

Morgan, Hywel, Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G

Over the last century a number of techniques have been developed which allow the measurement of the dielectric properties of biological particles in fluid suspension. The majority of these techniques...

Pexelizumab for acute ST-elevation myocardial infarction in patients undergoing primary percutaneous coronary intervention: a randomized controlled trial (2007)

Granger, Christopher B, Adams, Peter X, Hamm, Christian, Holmes, David, O'Neill, William W, ...

CONTEXT: Reperfusion with percutaneous transluminal coronary intervention (PCI) is effective at improving outcomes in patients with acute ST-elevation myocardial infarction (STEMI). However, in...

High speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences (2007)

Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G, Morgan, Hywel

A novel impedance spectroscopy technique has been developed for high speed single biological particle analysis. A microfluidic cytometer is used to measure the impedance of single micrometre sized...

High speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences (2007)

Sun, Tao, Holmes, David, Gawad, Shady, Green, Nicolas G, Morgan, Hywel

A novel impedance spectroscopy technique has been developed for high speed single biological particle analysis. A microfluidic cytometer is used to measure the impedance of single micrometre sized...

High-Throughput, Non-invasive and label-free single cell analysis on a microfluidic chip (2007)

Sun, Tao, Bernabini, Catia, Holmes, David, Green, Nicolas G, Morgan, Hywel

Cellular analysis requires a combination of biophysical and biochemical approaches for counting, manipulation and characterization of biological cells. In recent years, considerable attentions have...

High-Throughput, Non-invasive and label-free single cell analysis on a microfluidic chip (2007)

Sun, Tao, Bernabini, Catia, Holmes, David, Green, Nicolas G, Morgan, Hywel

Cellular analysis requires a combination of biophysical and biochemical approaches for counting, manipulation and characterization of biological cells. In recent years, considerable attentions have...

Label-Free Differential Leukocyte Counts Using a Microfabricated, Single-Cell Impedance Spectrometer (2007)

Holmes, David, Sun, Tao, Holloway, Judith, Cakebread, Julie, Davies, Donna, Morgan, Hywel

Impedance spectroscopy is a non-invasive technique which allows analysis of the electrical properties of biological cells and other materials. Typically, the electrical properties of a cell...

Label-Free Differential Leukocyte Counts Using a Microfabricated, Single-Cell Impedance Spectrometer (2007)

Holmes, David, Sun, Tao, Holloway, Judith, Cakebread, Julie, Davies, Donna, Morgan, Hywel

Impedance spectroscopy is a non-invasive technique which allows analysis of the electrical properties of biological cells and other materials. Typically, the electrical properties of a cell...

Bead-based immunoassays using a micro-chip flow cytometer (2007)

Holmes, David, She, J, Roach, P, Morgan, Hywel

A microfabricated flow cytometer has been developed for the analysis of micron-sized polymer beads onto which fluorescently labelled proteins have been immobilised. Fluorescence measurements were...

PAPER www.rsc.org/loc | Lab on a Chip High (2007)

Tao Sun, David Holmes, Shady Gawad, Nicolas G. Green, Hywel Morgan

speed multi-frequency impedance analysis of single particles in a microfluidic cytometer using maximum length sequences{

Insights into the iron and sulfur energetic metabolism of Acidithiobacillus ferrooxidans by microarray transcriptome profiling (2006)

Quatrini, Raquel, Appia-Ayme, Corinne, Denis, Yann, Ratouchniak, Jeanine, Veloso, Felipe, Valdés, Jorge, ...

Acidithiobacillus ferrooxidans is a well known acidophilic, chemolithoautotrophic, Gram negative, bacterium involved in bioleaching and acid mine drainage. In aerobic conditions, it gains energy...

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection (2006)

Holmes, David, Morgan, Hywel, Green, Nicolas G

A microflow cytometer has been fabricated that detects and counts fluorescent particles flowing through a microchannel at a high speed based upon their fluorescence emission intensity....

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection (2006)

Holmes, David, Morgan, Hywel, Green, Nicolas G

A microflow cytometer has been fabricated that detects and counts fluorescent particles flowing through a microchannel at a high speed based upon their fluorescence emission intensity....

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection (2006)

Holmes, David, Morgan, Hywel, Green, Nicolas G

A microflow cytometer has been fabricated that detects and counts fluorescent particles flowing through a microchannel at a high speed based upon their fluorescence emission intensity....

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection (2006)

Holmes, David, Morgan, Hywel, Green, Nicolas G

A microflow cytometer has been fabricated that detects and counts fluorescent particles flowing through a microchannel at a high speed based upon their fluorescence emission intensity....

A Real-time Java Virtual Machine for Avionics, An Experience Report (2006)

Jason Baker, Austin Armbruster, Chapman Flack, Filip Pizlo, Marek Prochazka, Jan Vitek, ...

ed for the DARPA PCES Capstone Demo We report on our experience with the implementation of the Real-time Specification for Java (RTSJ) in the DARPA Program Composition for Embedded System (PCES)...

On-chip high-speed sorting of micron-sized particles for high-throughput analysis (2005)

Holmes, David, Sandison, Mairi, Green, Nicolas G, Morgan, Hywel

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by...

On-chip high-speed sorting of micron-sized particles for high-throughput analysis (2005)

Holmes, David, Sandison, Mairi, Green, Nicolas G, Morgan, Hywel

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by...

On-chip high-speed sorting of micron-sized particles for high-throughput analysis (2005)

Holmes, David, Sandison, Mairi, Green, Nicolas G, Morgan, Hywel

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by...

On-chip high-speed sorting of micron-sized particles for high-throughput analysis (2005)

Holmes, David, Sandison, Mairi, Green, Nicolas G, Morgan, Hywel

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by...

On-chip high-speed sorting of micron-sized particles for high-throughput analysis (2005)

Holmes, David, Sandison, Mairi, Green, Nicolas G, Morgan, Hywel

A new design of particle sorting chip is presented. The device employs a dielectrophoretic gate that deflects particles into one of two microfluidic channels at high speed. The device operates by...

Microfabricated Barcodes for Particle Identification (2005)

Banu, Shahanara, Birtwell, Sam, Galatinov, Gerasim, Holmes, David, Zheludev, Nikolay, Morgan, Hywel

Microfabricated barcodes formed in SU8 photopolymer are presented as a method for identifying individual particles based on their diffraction patterns. Two designs of barcoded particles are...

Impedance based flow sensors (2005)

Green, Nicolas G, Tao, Sun, Holmes, David, Morgan, Hywel

Microfluidic analysis devices, often referred to as Micro Total Analysis Systems or the Lab-on-a-Chip, are often based on the manipulation of small volumes of fluid. These devices require the design...

Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing (2005)

Sandison, Mairi E, Malleo, Daniele, Holmes, David, Berry, Richard, Morgan, Hywel

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate),...

High speed simultaneous optical and impedance analysis of single particles (2005)

Morgan, Hywel, Holmes, David, Green, Nicolas G

In this work we report on the development of biochips for the rapid analysis of single cells and other particules. We have developed a device that can simultaneously measure the optical and...

Microfabricated Barcodes for Particle Identification (2005)

Banu, Shahanara, Birtwell, Sam, Galatinov, Gerasim, Holmes, David, Zheludev, Nikolay, Morgan, Hywel

Microfabricated barcodes formed in SU8 photopolymer are presented as a method for identifying individual particles based on their diffraction patterns. Two designs of barcoded particles are...

Impedance based flow sensors (2005)

Green, Nicolas G, Tao, Sun, Holmes, David, Morgan, Hywel

Microfluidic analysis devices, often referred to as Micro Total Analysis Systems or the Lab-on-a-Chip, are often based on the manipulation of small volumes of fluid. These devices require the design...

Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing (2005)

Sandison, Mairi E, Malleo, Daniele, Holmes, David, Berry, Richard, Morgan, Hywel

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate),...

High speed simultaneous optical and impedance analysis of single particles (2005)

Morgan, Hywel, Holmes, David, Green, Nicolas G

In this work we report on the development of biochips for the rapid analysis of single cells and other particules. We have developed a device that can simultaneously measure the optical and...

Microfabricated Barcodes for Particle Identification (2005)

Banu, Shahanara, Birtwell, Sam, Galatinov, Gerasim, Holmes, David, Zheludev, Nikolay, Morgan, Hywel

Microfabricated barcodes formed in SU8 photopolymer are presented as a method for identifying individual particles based on their diffraction patterns. Two designs of barcoded particles are...

Impedance based flow sensors (2005)

Green, Nicolas G, Tao, Sun, Holmes, David, Morgan, Hywel

Microfluidic analysis devices, often referred to as Micro Total Analysis Systems or the Lab-on-a-Chip, are often based on the manipulation of small volumes of fluid. These devices require the design...

Artificial bilayer lipid membranes (BLMs) on-chip for single molecule sensing (2005)

Sandison, Mairi E, Malleo, Daniele, Holmes, David, Berry, Richard, Morgan, Hywel

A polymer microfluidic device for the formation of artificial bilayer lipid membranes (BLMs) on-chip is described. The device is fabricated from thin, transparent films of poly(methyl methacrylate),...

High speed simultaneous optical and impedance analysis of single particles (2005)

Morgan, Hywel, Holmes, David, Green, Nicolas G

In this work we report on the development of biochips for the rapid analysis of single cells and other particules. We have developed a device that can simultaneously measure the optical and...

Microfabricated Device for Rapid Impedance Measurements on Single Biological Cells (2004)

Holmes, David, Neal, Becky, Green, Nicolas G, Morgan, Hywel

A microfluidic chip for performing impedance measurements on micron-sized particles is presented. The device consists of micro-electrodes patterned onto pyrex glass wafers and a microfluidic channel...

Microfabricated Device for Rapid Impedance Measurements on Single Biological Cells (2004)

Holmes, David, Neal, Becky, Green, Nicolas G, Morgan, Hywel

A microfluidic chip for performing impedance measurements on micron-sized particles is presented. The device consists of micro-electrodes patterned onto pyrex glass wafers and a microfluidic channel...

Microfabricated Device for Rapid Impedance Measurements on Single Biological Cells (2004)

Holmes, David, Neal, Becky, Green, Nicolas G, Morgan, Hywel

A microfluidic chip for performing impedance measurements on micron-sized particles is presented. The device consists of micro-electrodes patterned onto pyrex glass wafers and a microfluidic channel...

High speed particle sorting: combining dielectrophoresis and fluid flow (2004)

Holmes, David, Sandison, Mairi E, Green, Nicolas G, Morgan, Hywel

We present a high-speed particle sorting and deflection system which is an integral part of a micro-flow cytometer chip capable of high speed detection and sorting of micron sized particles. The...

High speed particle sorting: combining dielectrophoresis and fluid flow (2004)

Holmes, David, Sandison, Mairi E, Green, Nicolas G, Morgan, Hywel

We present a high-speed particle sorting and deflection system which is an integral part of a micro-flow cytometer chip capable of high speed detection and sorting of micron sized particles. The...

Microdevices for Dielectrophoretic Flow-Through Cell Separation (2003)

Holmes, David, Green, Nicolas G, Morgan, Hywel

Comparing Experiments with Numerical Simulation for a Novel System that Separates and Fractionates Particles from a Fluid Stream

Microdevices for Dielectrophoretic Flow-Through Cell Separation (2003)

Holmes, David, Green, Nicolas G, Morgan, Hywel

Comparing Experiments with Numerical Simulation for a Novel System that Separates and Fractionates Particles from a Fluid Stream

Microdevices for Dielectrophoretic Flow-Through Cell Separation (2003)

Holmes, David, Green, Nicolas G, Morgan, Hywel

Comparing Experiments with Numerical Simulation for a Novel System that Separates and Fractionates Particles from a Fluid Stream

3D focusing of nanoparticles in microfluidic channels (2003)

Morgan, Hywel, Holmes, David, Green, Nicolas G

Dynamic focusing of particles can be used to centre particles in a fluid stream, ensuring the passage of the particles through a specified detection volume. This paper describes a method for focusing...

3D focusing of nanoparticles in microfluidic channels (2003)

Morgan, Hywel, Holmes, David, Green, Nicolas G

Dynamic focusing of particles can be used to centre particles in a fluid stream, ensuring the passage of the particles through a specified detection volume. This paper describes a method for focusing...

3D focusing of nanoparticles in microfluidic channels (2003)

Morgan, Hywel, Holmes, David, Green, Nicolas G

Dynamic focusing of particles can be used to centre particles in a fluid stream, ensuring the passage of the particles through a specified detection volume. This paper describes a method for focusing...

Advanced dielectrophoretic cell separation systems / (2003)

Holmes, David.

Ph. D. thesis submitted to the Department of Electronics and Electrical Engineering, University of Glasgow, 2003.

BIOTECHNOLOGY ISSUES FOR DEVELOPING COUNTRIES - Latin American Genome Initiative, the Creation of a Network and Web Based Resource to Aid and Nurture Genome Biology in Developing Countries (2002)

Ramírez, Jose Luis, González, Alicia, Cantú, José María, Chavez-Crooker, Pamela, Leiva, Juan Carlos, Blamey, Jenny M., ...

As never before, biological and medical sciences in Latin America have been caught unprepared with the explosive development of genome biology with its concomitant use of high-throughput...

Cell positioning and sorting using dielectrophoresis. (2002)

Holmes, David, Morgan, Hywel

INTRODUCTION: In this paper we describe a micro-fabricated cell separation and positioning system based on the AC electrokinetic technique, dielectrophoresis (DEP). The system uses nonuniform...

Concurrency, Synchronisation and Objects (1999)

David Holmes

oncurrent programming, and even concurrent objects, is vast. Lea [Lea99] provides comprehensive, annotated lists of further readings throughout his book, covering the many different facets of...

Synchronisation Rings - Composable Synchronisation for Object-Oriented Systems (1999)

Synchronisation For, David Holmes

The integration of concurrent and object-oriented programming has been a challenge for over two decades. In this thesis we explore synchronisation in concurrent object-oriented programming and...

Aspects of Synchronisation (1998)

David Holmes, James Noble, John Potter

. Aspect oriented programming promotes the separation of the different aspects of a system into their natural form, and synchronisation is an important aspect of concurrent object oriented systems....

Effective Synchronisation of Concurrent Objects: Laying the Inheritance Anomaly to Rest (1998)

David Holmes, James Noble, John Potter

The integration of concurrency and object-oriented programming has been a goal of researchers for over a decade. To date, attempts to address reuse conflicts, known as "inheritance...

Using Relevance Feedback within the Relational Model for TREC-5 (1996)

David Grossman Carol, David A. Grossman, Carol Lundquist, John Reichart, David Holmes, Abdur Chowdhury, ...

For TREC-5, we enhanced our existing prototype that implements relevance ranking using the AT&T DBC-1012 Model 4 parallel database machine to include relevance feedback. We identified SQL to...

Using Relevance Feedback within the Relational Model for TREC-5 (1996)

David A. Grossman, Carol Lundquist, John Reichart, David Holmes, Abdur Chowdhury, Ophir Frieder

For TREC-5, we enhanced our existing prototype that implements relevance ranking using the AT&T DBC-1012 Model 4 parallel database machine to include relevance feedback. We identified SQL to...

Plano theater center / (1981)

Holmes, David.

Thesis (B.Arch.)--Texas Tech University, 1981.

Functional analysis of gapped microbial genomes: Amino acid metabolism of Thiobacillus ferrooxidans

Selkov, Evgeni, Overbeek, Ross, Kogan, Yakov, Chu, Lien, Vonstein, Veronika, Holmes, David, ...

A gapped genome sequence of the biomining bacterium Thiobacillus ferrooxidans strain ATCC23270 was assembled from sheared DNA fragments (3.2-times coverage) into 1,912 contigs. A total of 2,712...

Global Regulation of Gene Expression by ArlRS, a Two-Component Signal Transduction Regulatory System of Staphylococcus aureus

Liang, Xudong, Zheng, Li, Landwehr, Christina, Lunsford, Dwayne, Holmes, David, Ji, Yinduo

Staphylococcus aureus expresses various cell wall-associated and extracellular virulence factors, coordinately controlled by different two-component signal transduction systems and transcriptional...

Inactivation of a Two-Component Signal Transduction System, SaeRS, Eliminates Adherence and Attenuates Virulence of Staphylococcus aureus

Liang, Xudong, Yu, Chuanxin, Sun, Junsong, Liu, Hong, Landwehr, Christina, Holmes, David, ...

Staphylococcus aureus is a major human and animal pathogen. During infection, this organism not only is able to attach to and enter host cells by using its cell surface-associated factors but also...

Phylogenomic and Biochemical Characterization of Three Legionella pneumophila Polypeptide Deformylases

Huang, Jianzhong, Van Aller, Glenn S., Taylor, Amy N., Kerrigan, John J., Liu, Wu-Schyong, Trulli, Janice M., ...

Legionella pneumophila is a gram-negative facultative intracellular human pathogen that can cause fatal Legionnaires' disease. Polypeptide deformylase (PDF) is a novel broad-spectrum antibacterial...