Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I., Matthews, Stephen G., Hanson, Mark A.
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and...
Flanagan, Daniel E., Vaile, Julian C., Petley, Graham W., Phillips, David I., Godsland, Ian F., Owens, Phillip, ...
OBJECTIVES: Leptin, an important hormonal regulator of body weight, has been shown to stimulate the sympathetic nervous system (SNS) in vitro although the physiological relevance remains unclear....
Kajantie, Eero, Feldt, Kimmo, Raikkonen, Katri, Phillips, David I., Osmond, Clive, Heinonen, Kati, ...
Background: Studies in humans and animals have suggested intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA) function as an important mechanism in linking fetal life conditions...
Kensara, Osama A., Wooton, Steve A., Phillips, David I., Patel, Mayank, Hoffman, Daniel J., Jackson, Alan A., ...
The effect of fetal programming on intermediary metabolism is uncertain. Therefore, we examined whether fetal programming affects oxidative and nonoxidative macronutrient metabolism and the...
De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I., Osmond, Clive, Michels, Robert P., Bossuyt, Patrick M., ...
OBJECTIVE: The hypothalamic-pituitary-adrenal (HPA) axis has been proposed to be susceptible to fetal programming, the process by which an adverse fetal environment elicits permanent physiological...
Fetal growth and the adrenocortical response to psychological stress (2006)
Jones, Alexander, Godfrey, Keith M., Wood, Peter, Osmond, Clive, Goulden, Peter, Phillips, David I.
CONTEXT: Experimental studies in animals show that adverse prenatal environments lead to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal axis, which mediates the stress...
Kajantie, Eero, Phillips, David I., Osmond, Clive, Barker, David J., Forsen, Tom, Eriksson, Johan G.
BACKGROUND: The relationships of early growth with coronary heart disease and type 2 diabetes have received considerable attention. It is not known whether fetal or childhood growth is linked with...
Kensara, Osama A., Wootton, Steve A., Phillips, David I., Patel, Mayke, Jackson, Alan A., Elia, Marinos
Background: Reduced fetal growth is associated with differences in body composition in adult life that may predispose to cardiovascular disease and diabetes. Most published data are based on simple...
Aihie-Sayer, Avan, Syddall, Holly E., Dennison, Elaine M., Gilbody, Helen J., Duggleby, Sarah L., Cooper, Cyrus, ...
Background: Size in early life is related to adult body mass index, and early environmental influences have been proposed to have lifelong consequences for obesity. However, body mass index also...
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Dennison, Elaine M., Phillips, David I.
A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the...
Reynolds, Rebecca M., Syddall, Holly E., Walker, Brian R., Wood, Peter J., Phillips, David I.
Increasing evidence suggests that activation of the hypothalamic-pituitary-adrenal (HPA) axis may contribute to the pathogenesis of the metabolic syndrome and obesity. The mechanisms are unknown but...
Bertram, Caroline, Khan, Omar, Ohri, Sunil, Phillips, David I, Matthews, Stephen G, Hanson, Mark A
The perinatal environment is a powerful determinant of risk for developing disease in later life. Here, we have shown that maternal undernutrition causes dramatic changes in heart structure and...