Schlotz, Wolff, Jones, Alexander, Phillips, David I.W., Gale, Catharine R., Robinson, Sian M., Godfrey, Keith M.
Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary...
Boyne, Michael S., Woollard, Alexander, Phillips, David I.W., Taylor-Bryan, Carolyn, Bennett, Franklyn I., Osmond, Clive, ...
Hyperactivity of the hypothalamic—pituitary—adrenal axi (HPAA) resulting fromfetal programming may play a role in the development of high blood pressure (BP) in black people. We assessed the...
Fetal origins of mental health: evidence and mechanisms (2009)
Schlotz, Wolff, Phillips, David I.W.
The concept of fetal programming states that changes in the fetal environment during sensitive periods of organ development may cause long-lasting changes in the structure and functioning of these...
Schlotz, Wolff, Jones, Alexander, Godfrey, Keith M., Phillips, David I.W.
Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on...
Sex-specific programming of cardiovascular physiology in children (2008)
Jones, Alexander, Beda, Alessandro, Osmond, Clive, Godfrey, Keith M., Simpson, David M., Phillips, David I.W.
Aims: Increasing evidence suggests that adverse prenatal environments, as indicated by low birth weight, cause long-term changes in cardiovascular physiology that predispose to circulatory disease....
Sex-specific programming of cardiovascular physiology in children (2008)
Jones, Alexander, Beda, Alessandro, Osmond, Clive, Godfrey, Keith M., Simpson, David M., Phillips, David I.W.
Aims Increasing evidence suggests that adverse prenatal environments, as indicated by low birth weight, cause long-term changes in cardiovascular physiology that predispose to circulatory disease....
Size at birth and motor activity during stress in children aged 7-9 years (2007)
Schlotz, Wolff, Jones, Alexander, Phillips, Naomi M.M., Godfrey, Keith M., Phillips, David I.W.
Objective: Small size at birth is linked with metabolic and cardiovascular disease. There is increasing evidence that it is also linked with physiological stress responses and abnormal behaviour, in...
Schlotz, Wolff, Ambery, Phil, Syddall, Holly E., Crozier, Sarah R., Sayer, Avan Aihie, Cooper, Cyrus, ...
Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This...
Size at birth and autonomic function during psychological stress (2007)
Jones, Alexander, Beda, Alessandro, Ward, Alexandra M.V., Osmond, Clive, Phillips, David I.W., Moore, Vivienne M., ...
Small size at birth is associated with exaggerated blood pressure responses to psychological stressors, which increase the risk of developing sustained hypertension in adult life. Explanatory...
Alharbi, Khalid K., Spanakis, Emmanuel, Tan, Karen, Smith, Matt J., Aldahmesh, Mohammed A., O'Dell, Sandra D., ...
Identification of unknown mutations has remained laborious, expensive, and only viable for studies of selected cases. Population-based "reference ranges" of rarer sequence diversity are not...
Size at birth and motor activity during stress in children aged 7 to 9 years (2007)
Schlotz, Wolff, Jones, Alexander, Phillips, Naomi M.M., Godfrey, Keith M., Phillips, David I.W.
OBJECTIVES: Small size at birth is linked with metabolic and cardiovascular disease. There is increasing evidence that it is also linked with physiologic stress responses and abnormal behavior, in...
De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I.W., Osmond, Clive, Tanck, Michael W.T., Bossuyt, Patrick M.M., ...
Experimental studies in animals show that prenatal undernutrition leads to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Some studies have shown associations...
Kajantie, Eero, Phillips, David I.W.
Whether one is male or female is one of the most important determinants of human health. While males are more susceptible to cardiovascular and infectious disease, they are outnumbered by women for...
Rodríguez, Santiago, Gaunt, Tom R., Dennison, Elaine, Chen, Xiao-he, Syddall, Holly E., Phillips, David I.W., ...
Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH*5 and tagged by allele...
De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I.W., Osmond, Clive, Tanck, Michael W.T., Defesche, Joep C., ...
OBJECTIVE: An adverse fetal environment may permanently modify the effects of specific genes on glucose tolerance, insulin secretion, and insulin sensitivity. In the present study, we assessed a...
Impaired insulin secretion after prenatal exposure to the Dutch famine (2006)
De Rooij, Susanne R., Painter, Rebecca C., Phillips, David I.W., Osmond, Clive, Michels, Robert P.J., Godsland, Ian F., ...
OBJECTIVE: We previously reported that people prenatally exposed to famine during the Dutch Hunger Winter of 1944-1945 have higher 2-h glucose concentrations after an oral glucose tolerance test in...
Fetal growth and the adrenocortical response to psychological stress (2006)
Jones, Alexander, Godfrey, Keith M., Wood, Peter, Osmond, Clive, Goulden, Peter, Phillips, David I.W.
Context: Experimental studies in animals show that adverse prenatal environments lead to lifelong alterations in the activity of the hypothalamic-pituitary-adrenal axis which mediates the stress...
Phillips, David I.W., Goulden, Peter, Syddall, Holly E., Aihie Sayer, Avan, Dennison, Elaine M., Martin, Helen, ...
The Hertfordshire Cohort Study based in the U.K. was the first to report associations between fetal or infant growth and the prevalence of adult glucose intolerance and diabetes. Many studies have...
Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? (2005)
Aihie-Sayer, Avan, Dennison, Elaine M., Syddall, Holly E., Gilbody, Helen J., Phillips, David I.W., Cooper, Cyrus
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years (2005)
Kajantie, Eero, Osmond, Clive, Barker, David J.P., Forsén, Tom, Phillips, David I.W., Eriksson, Johan G.
Background: Small body size at birth, as a marker of an adverse intrauterine environment, has recently emerged as an important risk factor for death from cardiovascular disease. Our aim was to study...
Alharbi, Khalid K., Aldahmesh, Mohammed A, Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A, Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Size at birth as a predictor of mortality in adulthood: a follow-up of 350 000 person-years (2005)
Kajantie, Eero, Osmond, Clive, Barker, David J. P., Forsén, Tom, Phillips, David I. W., Eriksson, Johan G.
Background Small body size at birth, as a marker of an adverse intrauterine environment, has recently emerged as an important risk factor for death from cardiovascular disease. Our aim was to study...
Day, Ian N. M., Chen, Xiao-He, Gaunt, Tom R., King, Tabitha H. T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Dennison, Elaine M., Phillips, David I.W.
A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the...
Day, Ian N., Chen, Xiao-he, Gaunt, Tom R., King, Tabitha H.T., Voropanov, Anca, Ye, Shu, ...
Low rates of fetal and infant growth are associated with the metabolic syndrome and cardiovascular disease in later life. We investigated common genetic variation in the GH-CSH gene cluster on...
Size at birth, the metabolic syndrome and 24-h salivary cortisol profile (2004)
Kajantie, Eero, Eriksson, Johan, Osmond, Clive, Wood, Peter J., Forsén, Tom, Barker, David J. P., ...
Objective: Individual variation in hypothalamic–pituitary–adrenal axis (HPAA) function has been suggested to be important in linking small size at birth with adult cardiovascular disease and its...
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Dennison, Elaine M., Phillips, David I.W.
A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the...
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Chrousos, George P., Phillips, David I.W.
Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an intermediary in the association between reduced fetal growth and adult cardiovascular and metabolic...
Ward, Alexandra M.V., Moore, Vivienne M., Steptoe, Andrew, Cockington, Richard A., Robinson, Jeffrey S., Phillips, David I.W.
Background: Epidemiological studies have repeatedly shown inverse associations between size at birth and blood pressure in later life. There is some evidence to suggest that exaggerated blood...
Ward, Alexandra M.V., Syddall, Holly E., Wood, Peter J., Chrousos, George P., Phillips, David I.W.
Fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis has been proposed as an intermediary in the association between reduced fetal growth and adult cardiovascular and metabolic...
Gaunt, Tom R., Chen, Xiao-he, King, Tabitha H.T., Voropanov, Anca, Shu, Ye, Rodriguez, Santiago, ...
Reynolds, Rebecca M., Syddall, Holly E., Walker, Brian R., Wood, Peter J., Phillips, David I. W.
Increasing evidence suggests that activation of the hypothalamic-pituitary-adrenal (HPA) axis may contribute to the pathogenesis of the metabolic syndrome and obesity. The mechanisms are unknown but...
Kajantie, Eero, Eriksson, Johan, Barker, David J., Forsén, Tom, Osmond, Clive, Wood, Peter J., ...
OBJECTIVE: Several studies show that low birthweight is associated with long-term alterations in the function of the hypothalamic-pituitary-adrenal axis (HPAA). We recently reported that the...
Herrick, Kirsten, Phillips, David I. W., Haselden, Soraya, Shiell, Alistair W., Campbell-Brown, Mary, Godfrey, Keith M.
Recent studies have linked maternal consumption of an unbalanced high-protein, low-carbohydrate diet in late pregnancy with raised adult blood pressure in the offspring. Because high-protein diets...
Cortisol and the metabolic syndrome in South Asians (2003)
Ward, Alexandra M.V., Fall, Caroline H.D., Stein, Claudia E., Kumaran, K., Veena, S.R., Wood, Peter J., ...
Objective: The cardiovascular risk factors which comprise the metabolic syndrome are associated with increased hypothalamic–pituitary–adrenal axis (HPAA) activity in some Caucasian populations....
Lutein and zeaxanthin status and risk of age-related macular degeneration (2003)
Gale, Catharine R., Hall, Nigel F., Phillips, David I.W., Martyn, Christopher N.
PURPOSE. To investigate the relation between plasma concentrations of lutein and zeaxanthin and age-related macular degeneration in a group of elderly men and women. METHODS. The Wisconsin...
Kajantie, Eero, Fall, Caroline H., Seppala, Markku, Koistinen, Riita, Dunkel, Leo, Yliharsila, Hilkka, ...
The IGF system is important in regulation of fetal and childhood growth. In later life, IGF-I and IGF-binding protein-1 (IGFBP-1) have been implicated in the pathogenesis of arteriosclerosis. They...
Loos, Ruth J.F., Phillips, David I.W., Fagard, Robert, Beunen, Gaston, Derom, Catherine, Mathieu, Chantal, ...
Objective: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences,...
Phillips, David I W, ...
OBJECTIVE: There is strong evidence that low birth weight is associated with glucose intolerance and diabetes in adults. We have carried out a twin study to distinguish among maternal influences,...
Insulin-like growth factor-I genotype and birthweight (2002)
Day, Ian N.M., King, Tabitha H.T., Chen, Xiao-he, Voropanov, Anca M., Ye, Shu, Syddall, Holly E., ...
Is birthweight associated with thyroid autoimmunity? A study in twins (2002)
Phillips, David I.W., Osmond, Clive, Baird, Janis, Huckle, Alison, Rees-Smith, Bernard
Although extensive studies have suggested that an individual's predisposition to develop autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) has a genetic component, a recent report...
Whorwood, Christopher B., Donovan, Stephen J., Flanagan, Daniel, Phillips, David I.W., Byrne, Christopher D.
Altered glucocorticoid hormone action may contribute to the etiology of the metabolic syndrome, but the molecular mechanisms are poorly defined. Tissue sensitivity to glucocorticoid is regulated by...
O'Dell, Sandra D., Syddall, Holly E., Sayer, Avan Aihie, Cooper, Cyrus, Fall, Caroline H.D., Dennison, Elaine M., ...
Ciliary neurotrophic factor (CNTF) administration reduces weight in leptin-resistant mice via the signalling pathway normally activated by leptin. A G>A null mutation in the CNTF gene results in...
Endocrine programming and fetal origins of adult disease (2002)
Low birthweight and other indices of reduced fetal growth are associated with a raised prevalence of cardiovascular disease in adult life and its antecedents, including raised blood pressure, glucose...
Kajantie, Eero, Phillips, David I.W., Andersson, Sture, Barker, David J.P., Dunkel, Leo, Forsen, Tom, ...
Objective: Recent studies have suggested that lifelong programming of the hypothalamic–pituitary–adrenal (HPA) axis in utero is an important mechanism in explaining the link between small size at...
Relation between size at birth and risk of age-related macular degeneration (2002)
Hall, Nigel F., Gale, Catharine R., Syddall, Holly, Martyn, Christopher N., Phillips, David I.W.
PURPOSE. To determine whether poor fetal growth, as determined by size at birth, is associated with increased risk of age-related macular degeneration. METHODS. A total of 660 men and women born in...
Reynolds, Rebecca M., Walker, Brian R., Syddall, Holly E., Whorwood, Christopher B., Wood, Peter J., Phillips, David I.W.
Recent evidence suggests that variations in cortisol activity within the physiological range contribute to associations between multiple cardiovascular risk factors. Plasma cortisol measurements...
Reynolds, Rebecca M., Walker, Brian R., Syddall, Holly E., Andrew, Ruth, Wood, Peter J., Whorwood, Christopher B., ...
It has been suggested that increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with subsequent development of cardiovascular risk factors and disease. Two hundred...
Plasma antioxidant vitamins and carotenoids and age-related cataract (2001)
Gale, Catharine R., Hall, Nigel F., Phillips, David I.W., Martyn, Christopher N.
Objective: To investigate the relationships between plasma concentrations of antioxidant vitamins and carotenoids and nuclear, cortical, and posterior subcapsular cataracts in a group of elderly men...
Relation between size at birth and age-related cataract (2001)
Hall, Nigel F., Gale, Catharine R., Syddall, Holly E., Martyn, Christpher N., Phillips, David I.W.
PURPOSE. To determine whether poor fetal growth, as determined by size at birth, is associated with an increased risk of age-related cataract. METHODS. A total of 741 men and women born in Sheffield,...
Associations of micro-albuminuria with intra-uterine growth retardation (2001)
Yudkin, John S., Martyn, Christopher N., Phillips, David I.W., Gale, Catherine R.
Background/Aim: Micro-albuminuria is associated with insulin resistance and a high blood pressure and predicts an increased risk of cardiovascular disease in both diabetic and non-diabetic...
Fetal growth and programming of the hypothalamic-pituitary-adrenal axis (2001)
1. Epidemiological studies have shown that small size at birth is associated with an increased risk of coronary heart disease and its risk factors, including hypertension and type 2 diabetes. 2. It...
Twin studies and estimates of heritability (2001)
Loos, Ruth J., Beunen, Gaston, Fagard, Robert, Derom, Catharine, Vlietinck, Robert, Phillips, David I.W.
Fetal growth and the fetal origins hypothesis in twins-problems and perspectives (2001)
Phillips, David I.W., Davies, Michael J., Robinson, Jeffrey S.
Although there is substantial evidence from studies of singletons that small size at birth is linked with long-term adverse health effects, until recently little was known as to whether these...
Reynolds, Rebecca M., Walker, Brian R., Syddall, Holly E., Whorwood, Christopher B., Wood, Peter J., Phillips, David I.W.
Recent evidence suggests that variations in cortisol activity within the physiological range contribute to associations between multiple cardiovascular risk factors. Plasma cortisol measurements...
Matthews, Stephen G, Phillips, David I W, Challis, John R G, Cox, David B, Thomas, Eric Jackson, McMillen, Isabella Caroline, ...
McDonald, Roger B, Wintour, E Marelyn, Morrison, Janna Leigh, Sloboda, Deborah M, Matthews, Stephen G, Phillips, David I W, ...
McDonald, Roger B, Wintour, E Marelyn, Morrison, Janna Leigh, Sloboda, Deborah M, Matthews, Stephen G, Phillips, David I W, ...
PHILLIPS, DAVID I W, OSMOND, CLIVE
Phillips D I W (Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK) and Osmond C. Iodine supplementation with oral or intramuscular iodized oil. A...
PHILLIPS, DAVID I W, LUSTY, TIM D, OSMOND, CUVE, CHURCH, DAVID
A community-based controlled trial of iodine supplementation comparing oral or intramuscular iodized oil with oral potassium iodide has been carried out in 23 severely iodine-deficient villages in...
Prenatal growth and subsequent marital status: longitudinal study
Phillips, David I W, Handelsman, David J, Eriksson, Johan G, Forsén, Tom, Osmond, Clive, Barker, David J P
Risk of macular degeneration in users of statins: cross sectional study
Hall, Nigel F, Gale, Catharine R, Syddall, Holly, Phillips, David I W, Martyn, Christopher N
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Prenatal growth and subsequent marital status: longitudinal study
Phillips, David I W, Handelsman, David J, Eriksson, Johan G, Forsén, Tom, Osmond, Clive, Barker, David J P
Risk of macular degeneration in users of statins: cross sectional study
Hall, Nigel F, Gale, Catharine R, Syddall, Holly, Phillips, David I W, Martyn, Christopher N
Alharbi, Khalid K., Aldahmesh, Mohammed A., Spanakis, Emmanuel, Haddad, Lema, Whittall, Roslyn A., Chen, Xiao-he, ...
We have developed a mutation-scanning approach suitable for whole population screening for unknown mutations. The method, meltMADGE, combines thermal ramp electrophoresis with MADGE to achieve...
Phillips, David I W, Jones, Alexander
Studies in several species have demonstrated that an adverse early environment can influence the development of the autonomic nervous system and hypothalamic–pituitary–adrenal (HPA) axis. The...