Thurfjell, Lennart, Owenius, Rikard, ...
(11)C-Pittsburgh compound B (PiB) marks Abeta amyloidosis, a key pathogenetic process in Alzheimer disease (AD). The use of (11)C-PiB is limited to centers with a cyclotron. Development of the...
Improving Grammar Learning Using Seed-Sets (2008)
Probabilistic Context-Free Grammars have been unsuccessful in learning natural language, due to the complexity of the task. Considerable research has been conducted into methods of reducing the...
Improving Word-Based Predictive Text Entry with Transformation-Based Learning (2008)
Abstract. Predictive text interfaces allow for text entry on mobile phones, using only a 12-key numeric keypad. While current predictive text systems require only around 1 keystroke per character...
Ines K. Goerendt, Cristina Messa, Andrew D. Lawrence, Paul M. Grasby, Paola Piccini, David J. Brooks, ...
Parkinson's disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting...
Cognitive deficits and striato-frontal dopamine release in Parkinson's disease (2008)
Sawamoto, Nobukatsu, Piccini, Paola, Hotton, Gary, Pavese, Nicola, Thielemans, Kris, Brooks, David J.
Idiopathic Parkinson's disease (PD) is often accompanied by a pattern of executive deficits similar to those found in patients with frontal lobe lesions. We investigated whether such cognitive...
Service United States Department of Agriculture (2007)
Recreation And Tourism, United States, David J. Brooks, Richard W. Haynes
This page has been left blank intentionally. Document continues on next page. Opportunities to participate in outdoor recreation are an important component of the quality of life for residents of...
Microglial activation in presymptomatic Huntington's disease gene carriers (2007)
Tai, Yen F., Pavese, Nicola, Gerhard, Alexander, Tabrizi, Sarah J., Barker, Roger A., Brooks, David J., ...
Microglial activation may play a role in the pathogenesis of Huntington's disease (HD). Using 11C-(R)-PK11195 (PK) positron emission tomography (PET), we investigated microglial activation in HD...
Upregulation of opioid receptor binding following spontaneous epileptic seizures (2007)
Hammers, Alexander, Asselin, Marie-Claude, Hinz, Rainer, Kitchen, Ian, Brooks, David J., Duncan, John S., ...
Animal and limited human data suggest an important anticonvulsant role for opioid peptides and their receptors. We aimed to provide direct human in vivo evidence for changes in opioid receptor...
Williams, Tim M., Daglish, Mark, Lingford-Hughes, Anne, Taylor, Lindsay G., Hammers, Alexander, Brooks, David J., ...
Background Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood. Aims This study sought to...
Williams, Tim M., Daglish, Mark, Lingford-Hughes, Anne, Taylor, Lindsay G., Hammers, Alexander, Brooks, David J., ...
Background Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood. Aims This study sought to...
Upregulation of opioid receptor binding following spontaneous epileptic seizures (2007)
Hammers, Alexander, Asselin, Marie-Claude, Hinz, Rainer, Kitchen, Ian, Brooks, David J., Duncan, John S., ...
Animal and limited human data suggest an important anticonvulsant role for opioid peptides and their receptors. We aimed to provide direct human in vivo evidence for changes in opioid receptor...
Upregulation of opioid receptor binding following spontaneous epileptic seizures (2007)
Hammers, Alexander, Asselin, Marie-Claude, Hinz, Rainer, Kitchen, Ian, Brooks, David J., Duncan, John S., ...
Animal and limited human data suggest an important anticonvulsant role for opioid peptides and their receptors. We aimed to provide direct human in vivo evidence for changes in opioid receptor...
Factors affecting the clinical outcome after neural transplantation in Parkinson's disease (2005)
Piccini, Paola, Pavese, Nicola, Hagell, Peter, Reimer, Jan, Björklund, Anders, Oertel, Wolfgang H., ...
Intrastriatal grafts of embryonic mesencephalic tissue can survive in the brains of patients with Parkinson's disease, but the degree of symptomatic relief is highly variable and some cases develop...
The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study (2005)
Von Spiczak, Sarah, Whone, Alan L., Hammers, Alexander, Asselin, Marie-Claude, Turkheimer, Federico, Tings, Tobias, ...
Opioids have been shown to provide symptomatic relief from dysaesthesias and motor symptoms in restless legs syndrome (RLS). However, the mechanisms by which endogenous opioids contribute to the...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin mutations were...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre‐ and postsynaptic dopaminergic function in parkin‐linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin...
Reward Processing in Health and Parkinson's Disease: Neural Organization and Reorganization (2004)
Goerendt, Ines K., Lawrence, Andrew D., Brooks, David J.
It has been suggested that motivational processes mediated by dopaminergic neural systems may be relatively spared in Parkinson’s disease (PD) and activation of these pathways may be of therapeutic...
Scherfler, Christoph, Khan, Naheed L., Pavese, Nicola, Eunson, Louise, Graham, Elizabeth, Lees, Andrew J., ...
To investigate striatal and cortical pre- and postsynaptic dopaminergic function in parkin-linked parkinsonism, 13 unrelated patients homozygous or compound heterozygous for parkin mutations were...
Hammers, Alexander, Koepp, Matthias J., Richardson, Mark P., Hurlemann, René, Brooks, David J., Duncan, John S.
In 20-30% of potential surgical candidates with refractory focal epilepsy, standard MRI does not identify the cause. γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the...
Goerendt, Ines K., Messa, Cristina, Lawrence, Andrew D., Grasby, Paul M., Piccini, Paola, Brooks, David J.
Parkinson’s disease is associated with slowness, especially of sequential movements, and is characterized pathologically by degeneration of dopaminergic neurons, particularly targeting...
Pavese, Nicola, Andrews, Thomasin C., Brooks, David J., Ho, Aileen K., Rosser, Anne E., Barker, Roger A., ...
We have studied the progression of striatal and extrastriatal post‐synaptic dopaminergic changes in a group of 12 patients with Huntington’s disease using serial 11C‐raclopride PET, a...
Hammers, Alexander, Koepp, Matthias J., Richardson, Mark P., Hurlemann, René, Brooks, David J., Duncan, John S.
In 20-30% of potential surgical candidates with refractory focal epilepsy, standard MRI does not identify the cause. γ-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the...
Dyskinesias following neural transplantation in Parkinson's disease. (2002)
Hagell, Peter, Piccini, Paola, Björklund, Anders, Brundin, Patrik, Rehncrona, Stig, Widner, Håkan, ...
Severe dyskinesias during the 'off' phases (periods of increased Parkinson's disease (PD) disability) have been observed following intrastriatal transplantation of human embryonic mesencephalic...
Ito, Kengo, Nagano-Saito, Atsuko, Kato, Takashi, Arahata, Yutaka, Nakamura, Akinori, Kawasumi, Yasuhiro, ...
We investigated the relative differences in dopaminergic function through the whole brain in patients with Parkinson’s disease without dementia (PD) and with dementia (PDD) using...
Khan, Naheed L., Brooks, David J., Pavese, Nicola, Sweeney, Mary G., Wood, Nicholas W., Lees, Andrew J., ...
Molecular and clinical characterization of parkin‐associated parkinsonism is well described; however, there are no data available on progression of dopamine terminal dysfunction in...
Hammers, Alexander, Koepp, Matthias J., Richardson, Mark P., Labbé, Claire, Brooks, David J., Cunningham, Vincent J., ...
We calculated [11C]flumazenil volume of distribution ([11C]FMZ-Vd) after correction for partial volume effect in 10 patients with malformations of cortical development (MCDs) and...
Dagher, Alain, Owen, Adrian M., Boecker, Henning, Brooks, David J.
Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in...
Jenkins, I. Harri, Jahanshahi, Marjan, Jueptner, Markus, Passingham, Richard E., Brooks, David J.
Event-related potential studies in man suggest a role for the supplementary motor area (SMA) in movement preparation, particularly when movements are internally generated. In a previous study...
Brundin, Patrik, Pogarell, Oliver, Hagell, Peter, Piccini, Paola, Widner, Håkan, Schrag, Anette, ...
Five parkinsonian patients were transplanted bilaterally into the putamen and caudate nucleus with human embryonic mesencephalic tissue from between seven and nine donors. To increase graft survival,...
Huntington's disease progression: PET and clinical observations (1999)
Andrews, Thomasin C., Weeks, Robert A., Turjanski, Nora, Gunn, Roger N., Watkins, Laura H. A., Sahakian, Barbara, ...
Using serial [11C]SCH 23390- and [11C]raclopride-PET, we have measured the rate of loss of striatal dopamine D1 and D2 receptor binding over a mean of 40 months in nine...
Jahanshtri, Marjan, Jenkins, Harri, Brown, Richard G., Marsden, C. David, Passingham, Richard G., Brooks, David J.
Jahanshahi, Marjan, Jenkins, I. Harri, Brown, Richard G., Marsden, C. David, Passingham, Richard E., Brooks, David J.
We investigated the functional anatomy of self-initiated and externally triggered movements. Six patients with Parkinson's disease off medication and six age-matched normals were assessed. All...
Typescript.
Typescript (photocopy).
Thesis (Ph. D.)--Oregon State University, 1984.
Thesis (Ph. D.)--Oregon State University, 1983.
Includes vita.
Neuroimaging in Parkinson’s Disease
Summary: In this review, the potential role of positron emission tomography and single photon emission computed tomography as biological markers for diagnosing and following the progression of...
Positron Emission Tomography Imaging of Transplant Function
Summary: In this article, the role of functional imaging for providing objective evidence that grafts of fetal tissue can survive and form connections in Parkinson's and Huntington's disease patients...
Summary: In this review, the value of functional imaging [positron emission tomography (PET)/single-photon emission computed tomography (SPECT)] in drug development is considered. Radionuclide...
Imaging basal ganglia function
In this review, the value of functional imaging for providing insight into the role of the basal ganglia in motor control is reviewed. Brain activation findings in normal subjects and Parkinson's...
Neuroimaging in Parkinson’s Disease
Summary: In this review, the potential role of positron emission tomography and single photon emission computed tomography as biological markers for diagnosing and following the progression of...
Positron Emission Tomography Imaging of Transplant Function
Summary: In this article, the role of functional imaging for providing objective evidence that grafts of fetal tissue can survive and form connections in Parkinson's and Huntington's disease patients...
Summary: In this review, the value of functional imaging [positron emission tomography (PET)/single-photon emission computed tomography (SPECT)] in drug development is considered. Radionuclide...
Imaging basal ganglia function
In this review, the value of functional imaging for providing insight into the role of the basal ganglia in motor control is reviewed. Brain activation findings in normal subjects and Parkinson's...
After 40 years of clinical experience, levodopa remains the gold standard treatment for Parkinson’s disease (PD) despite the recent emergence of a host of new therapies. Some physicians are...