Martin, Matthew T., Mendez, Elizabeth, Corum, Daniel G., Judson, Richard S., Kavlock, Robert J., Rotroff, Daniel M., ...
Multigeneration reproduction studies are used to characterize parental and offspring systemic toxicity, as well as reproductive toxicity of pesticides, industrial chemicals and pharmaceuticals....
Goetz, Amber K., Dix, David J.
The mode of action for the reproductive toxicity of some triazole antifungals has been characterized as an increase in serum testosterone and hepatic response, and reduced insemination and fertility...
Martin, Matthew T., Brennan, Richard J., Hu, Wenyue, Ayanoglu, Eser, Lau, Christopher, Ren, Hongzu, ...
Toxicogenomic analysis of five environmental chemicals was performed to investigate the ability of genomics to predict toxicity, categorize chemicals, and elucidate mechanisms of toxicity. Three...
Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs (2007)
Platts, Adrian E., Dix, David J., Chemes, Hector E., Thompson, Kary E., Goodrich, Robert, Rockett, John C., ...
We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. Although the role of some of the structures and...
Success and Failure in Human Spermatogenesis as Revealed by Teratozoospermic RNAs (2007)
Platts, Adrian E., Dix, David J., Chemes, Hector E., Thompson, Kary E., Goodrich, Robert, Rockett, John C., ...
We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a suite of structures, proteins and RNAs. While the role of some of the structures and...
Goetz, Amber K., Ren, Hongzu, Schmid, Judith E., Blystone, Chad R., Thillainadarajah, Inthirany, Best, Deborah S., ...
Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes of action. Wistar Han rats were fed...
The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals (2007)
Dix, David J., Houck, Keith A., Martin, Matthew T., Richard, Ann M., Setzer, R. Woodrow, Kavlock, Robert J.
The U.S. Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS), and various toxicogenomic technologies to predict...
Adrian E. Platts, David J. Dix, Hector E. Chemes, Kary E. Thompson, Robert Goodrich, John C. Rockett, ...
please email: journals.permissions@oxfordjournals.org ABSTRACT-2-Platts et al. We are coming to appreciate that at fertilization human spermatozoa deliver the paternal genome alongside a...
The ToxCast Program for Prioritizing Toxicity Testing of Environmental Chemicals (2006)
Dix, David J., Houck, Keith A., Martin, Matthew T., Richard, Ann M., Setzer, R. Woodrow, Kavlock, Robert J.
The United States Environmental Protection Agency (EPA) is developing methods for utilizing computational chemistry, high-throughput screening (HTS) and various toxicogenomic technologies to predict...
Goetz, Amber K., Ren, Hongzu, Schmid, Judith E., Blystone, Chad R., Thillainadarajah, Inthirany, Best, Deborah S., ...
Triazole fungicides associated with a range of reported male reproductive effects in experimental animals were selected to assess potential toxic modes of action. Wistar Han rats were fed...
A bioinformatic strategy to rapidly characterize cDNA libraries (2002)
Ostermeier, G. Charles, Dix, David J., Krawetz, Stephen A.
Motivation: Complementary DNA libraries can define the genetic constituents of specific cells and/or tissues. Their sequencing will illuminate the transcriptome but it is a monumental task requiring...
Rockett, John C., Kavlock, Robert J., Lambright, Christy R., Parks, Louise G., Schmid, Judith E., Wilson, Vickie S., ...
We propose that gene expression changes in accessible tissues such as blood often reflect those in inaccessible tissues, thus offering a convenient biomonitoring method to provide insight into the...
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis (2001)
Rockett, John C, Christopher Luft, J, Brian Garges, J, Krawetz, Stephen A, Hughes, Mark R, Hee Kirn, Kwan, ...
Abstract Background Over the past five years, interest in and use of DNA array technology has increased dramatically, and there has been a surge in demand for different types of arrays. Although...
Typescript original and library bound.
Thesis (Ph. D.)--Rush University, 1990.
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
Rockett, John C, Christopher Luft, J, Brian Garges, J, Krawetz, Stephen A, Hughes, Mark R, Hee Kirn, Kwan, ...
Hsp70 expression and function during embryogenesis
Luft, J. Christopher, Dix, David J.
This review focuses on the expression and function of 70-kDa heat shock proteins (Hsp70s) during mammalian embryogenesis, though many features of embryogenesis and the developmental expression of...
Hsp 70 expression and function during gametogenesis
The dramatic transformations in nuclear content and cellular organization that occur during gametogenesis require unique regulation and execution of the mitotic and meiotic cell cycle, apoptotic cell...
Genomic Instability and Enhanced Radiosensitivity in Hsp70.1- and Hsp70.3-Deficient Mice
Hunt, Clayton R., Dix, David J., Sharma, Girdhar G., Pandita, Raj K., Gupta, Arun, Funk, Margo, ...
Heat shock proteins (HSPs) are highly conserved among all organisms from prokaryotes to eukaryotes. In mice, the HSP genes Hsp70.1 and Hsp70.3 are induced by both endogenous and exogenous stressors,...
Luft, J. Christopher, Benjamin, Ivor J., Mestril, Ruben, Dix, David J.
Mammalian cells respond to environmental stress by activating heat shock transcription factors (eg, Hsf1) that regulate increased synthesis of heat shock proteins (Hsps). Hsps prevent the disruption...
Development of a 950-gene DNA array for examining gene expression patterns in mouse testis
Rockett, John C, Christopher Luft, J, Brian Garges, J, Krawetz, Stephen A, Hughes, Mark R, Hee Kirn, Kwan, ...
Hsp70 expression and function during embryogenesis
Luft, J. Christopher, Dix, David J.
This review focuses on the expression and function of 70-kDa heat shock proteins (Hsp70s) during mammalian embryogenesis, though many features of embryogenesis and the developmental expression of...
Hsp 70 expression and function during gametogenesis
The dramatic transformations in nuclear content and cellular organization that occur during gametogenesis require unique regulation and execution of the mitotic and meiotic cell cycle, apoptotic cell...
Genomic Instability and Enhanced Radiosensitivity in Hsp70.1- and Hsp70.3-Deficient Mice
Hunt, Clayton R., Dix, David J., Sharma, Girdhar G., Pandita, Raj K., Gupta, Arun, Funk, Margo, ...
Heat shock proteins (HSPs) are highly conserved among all organisms from prokaryotes to eukaryotes. In mice, the HSP genes Hsp70.1 and Hsp70.3 are induced by both endogenous and exogenous stressors,...
Luft, J. Christopher, Benjamin, Ivor J., Mestril, Ruben, Dix, David J.
Mammalian cells respond to environmental stress by activating heat shock transcription factors (eg, Hsf1) that regulate increased synthesis of heat shock proteins (Hsps). Hsps prevent the disruption...