David J. Glass

Study of SCN Neurochemistry Using in Vivo Microdialysis in the Conscious Brain: Correlation with Overt Circadian Rhythms. (1998)

Glass, David J.

We have completed the assessment of the diurnal variation in serotonergic activity in the SCN and its temporal relationship to wheel-running behavior under lightentrained (LD 14:10) and free-running...

Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: Required role for the MuSK ectodomain?

Glass, David J., Apel, Elizabeth D., Shah, Sonal, Bowen, David C., DeChiara, Thomas M., Stitt, Trevor N., ...

Formation of the neuromuscular junction (NMJ) depends upon a nerve-derived protein, agrin, acting by means of a muscle-specific receptor tyrosine kinase, MuSK, as well as a required accessory...

Agrin in Alzheimer’s disease: Altered solubility and abnormal distribution within microvasculature and brain parenchyma

Donahue, John E., Berzin, Tyler M., Rafii, Michael S., Glass, David J., Yancopoulos, George D., Fallon, Justin R., ...

Agrin is a heparan sulfate proteoglycan that is widely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous system. Agrin induces the differentiation of...

Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

Lai, Ka-Man V., Gonzalez, Michael, Poueymirou, William T., Kline, William O., Na, Erqian, Zlotchenko, Elizabeth, ...

Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of atrophy is to...

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Cai, Dongsheng, Frantz, J. Daniel, Tawa, Nicholas E., Melendez, Peter A., Oh, Byung-Chul, Lidov, Hart G.W., ...

Muscle wasting accompanies aging and pathological conditions ranging from cancer, cachexia, and diabetes to denervation and immobilization. We show that activation of NF-κB, through muscle-specific...

Kinase domain of the muscle-specific receptor tyrosine kinase (MuSK) is sufficient for phosphorylation but not clustering of acetylcholine receptors: Required role for the MuSK ectodomain?

Glass, David J., Apel, Elizabeth D., Shah, Sonal, Bowen, David C., DeChiara, Thomas M., Stitt, Trevor N., ...

Formation of the neuromuscular junction (NMJ) depends upon a nerve-derived protein, agrin, acting by means of a muscle-specific receptor tyrosine kinase, MuSK, as well as a required accessory...

Agrin in Alzheimer’s disease: Altered solubility and abnormal distribution within microvasculature and brain parenchyma

Donahue, John E., Berzin, Tyler M., Rafii, Michael S., Glass, David J., Yancopoulos, George D., Fallon, Justin R., ...

Agrin is a heparan sulfate proteoglycan that is widely expressed in neurons and microvascular basal lamina in the rodent and avian central nervous system. Agrin induces the differentiation of...

Conditional Activation of Akt in Adult Skeletal Muscle Induces Rapid Hypertrophy

Lai, Ka-Man V., Gonzalez, Michael, Poueymirou, William T., Kline, William O., Na, Erqian, Zlotchenko, Elizabeth, ...

Skeletal muscle atrophy is a severe morbidity caused by a variety of conditions, including cachexia, cancer, AIDS, prolonged bedrest, and diabetes. One strategy in the treatment of atrophy is to...

Two tales concerning skeletal muscle

Glass, David J.

It was previously appreciated that the determination of skeletal muscle fiber type (fast or slow) could be regulated by class II histone deacetylases (HDACs), which function by inhibiting the...

Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3

Fielitz, Jens, Kim, Mi-Sung, Shelton, John M., Latif, Shuaib, Spencer, Jeffrey A., Glass, David J., ...

Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere. Abnormalities in...

Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins

Li, Hui-Hua, Willis, Monte S., Lockyer, Pamela, Miller, Nathaniel, McDonough, Holly, Glass, David J., ...

Cardiac hypertrophy is a major cause of human morbidity and mortality. Although much is known about the pathways that promote hypertrophic responses, mechanisms that antagonize these pathways have...

Distinct Domains of Musk Mediate Its Abilities to Induce and to Associate with Postsynaptic Specializations

Zhou, Heather, Glass, David J., Yancopoulos, George D., Sanes, Joshua R.

Agrin released from motor nerve terminals activates a muscle-specific receptor tyrosine kinase (MuSK) in muscle cells to trigger formation of the skeletal neuromuscular junction. A key step in...