Lefterova, Martina I., Zhang, Yong, Steger, David J., Schupp, Michael, Schug, Jonathan, Cristancho, Ana, ...
Peroxisome proliferator-activated receptor γ(PPARγ), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, is known as the master regulator of adipocyte biology. Although it...
LiCalsi, Cynthia, Christophe, Sylvie, Steger, David J., Buescher, Marita, Fischer, Wolfgang, Mellon, Pamela L.
The AP-2 family of transcriptional regulator proteins has three members, α, &bgr; and &ggr;. AP-2α and &ggr; are expressed in placenta and in the human trophoblast cell line JEG-3. AP-2 has been...
Steger, David J., Eberharter, Anton, John, Sam, Grant, Patrick A., Workman, Jerry L.
Protein acetylation has been implicated in the regulation of HIV-1 gene transcription. Here, we have exploited the activities of four native histone acetyltransferase (HAT) complexes from yeast to...
Ikeda, Keiko, Steger, David J., Eberharter, Anton, Workman, Jerry L.
Recent progress in identifying the catalytic subunits of histone acetyltransferase (HAT) complexes has implicated histone acetylation in the regulation of transcription. Here, we have analyzed the...
A Novel H2A/H4 Nucleosomal Histone Acetyltransferase in Tetrahymena thermophila
Ohba, Reiko, Steger, David J., Brownell, James E., Mizzen, Craig A., Cook, Richard G., Côté, Jacques, ...
Recently, we reported the identification of a 55-kDa polypeptide (p55) from Tetrahymena macronuclei as a catalytic subunit of a transcription-associated histone acetyltransferase (HAT A). Extensive...
AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin
LiCalsi, Cynthia, Christophe, Sylvie, Steger, David J., Buescher, Marita, Fischer, Wolfgang, Mellon, Pamela L.
The AP-2 family of transcriptional regulator proteins has three members, α, β and γ. AP-2α and γ are expressed in placenta and in the human trophoblast cell line JEG-3. AP-2 has been shown to...
Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
Vignali, Marissa, Steger, David J., Neely, Kristen E., Workman, Jerry L.
We analyzed the targeting of histone acetyltransferase (HAT) complexes by DNA-binding activators during transcriptional activation and the resulting distribution of acetylated histones. An in vitro...
The chromo domain protein Chd1p from budding yeast is an ATP-dependent chromatin-modifying factor
Tran, Hien G., Steger, David J., Iyer, Vishwanath R., Johnson, Alexander D.
CHD proteins are members of the chromo domain family, a class of proteins involved in transcription, DNA degradation and chromatin structure. In higher eukaryotes, there are two distinct subfamilies...
Regulation of Chromatin Remodeling by Inositol Polyphosphates
Steger, David J., Haswell, Elizabeth S., Miller, Aimee L., Wente, Susan R., OòShea, Erin K.
Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5...
Steger, David J., Eberharter, Anton, John, Sam, Grant, Patrick A., Workman, Jerry L.
Protein acetylation has been implicated in the regulation of HIV-1 gene transcription. Here, we have exploited the activities of four native histone acetyltransferase (HAT) complexes from yeast to...
Ikeda, Keiko, Steger, David J., Eberharter, Anton, Workman, Jerry L.
Recent progress in identifying the catalytic subunits of histone acetyltransferase (HAT) complexes has implicated histone acetylation in the regulation of transcription. Here, we have analyzed the...
A Novel H2A/H4 Nucleosomal Histone Acetyltransferase in Tetrahymena thermophila
Ohba, Reiko, Steger, David J., Brownell, James E., Mizzen, Craig A., Cook, Richard G., Côté, Jacques, ...
Recently, we reported the identification of a 55-kDa polypeptide (p55) from Tetrahymena macronuclei as a catalytic subunit of a transcription-associated histone acetyltransferase (HAT A). Extensive...
AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin
LiCalsi, Cynthia, Christophe, Sylvie, Steger, David J., Buescher, Marita, Fischer, Wolfgang, Mellon, Pamela L.
The AP-2 family of transcriptional regulator proteins has three members, α, β and γ. AP-2α and γ are expressed in placenta and in the human trophoblast cell line JEG-3. AP-2 has been shown to...
Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes
Vignali, Marissa, Steger, David J., Neely, Kristen E., Workman, Jerry L.
We analyzed the targeting of histone acetyltransferase (HAT) complexes by DNA-binding activators during transcriptional activation and the resulting distribution of acetylated histones. An in vitro...
The chromo domain protein Chd1p from budding yeast is an ATP-dependent chromatin-modifying factor
Tran, Hien G., Steger, David J., Iyer, Vishwanath R., Johnson, Alexander D.
CHD proteins are members of the chromo domain family, a class of proteins involved in transcription, DNA degradation and chromatin structure. In higher eukaryotes, there are two distinct subfamilies...
Steger, David J., Lefterova, Martina I., Ying, Lei, Stonestrom, Aaron J., Schupp, Michael, Zhuo, David, ...
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia. However, the normal...
PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale
Lefterova, Martina I., Zhang, Yong, Steger, David J., Schupp, Michael, Schug, Jonathan, Cristancho, Ana, ...
Peroxisome proliferator-activated receptor γ(PPARγ), a nuclear receptor and the target of anti-diabetic thiazolinedione drugs, is known as the master regulator of adipocyte biology. Although it...
Retinol saturase promotes adipogenesis and is downregulated in obesity
Schupp, Michael, Lefterova, Martina I., Janke, Jürgen, Leitner, Kirstin, Cristancho, Ana G., Mullican, Shannon E., ...
Adipocyte differentiation is controlled by many transcription factors, but few known downstream targets of these factors are necessary for adipogenesis. Here we report that retinol saturase (RetSat),...
Selective Partial Agonism of Liver X Receptor α Is Related to Differential Corepressor Recruitment
Phelan, Caroline A., Weaver, Joseph M., Steger, David J., Joshi, Shree, Maslany, Jeffrey T., Collins, Jon L., ...
Classically, activated transcription by nuclear receptors (NRs) is due to a ligand-induced switch from corepressor- to coactivator-bound states. However, coactivators and corepressors recognize...