Braff, David L., Freedman, Robert, Schork, Nicholas J., Gottesman, Irving I.
The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and identify the functional importance of...
Calkins, Monica E., Dobie, Dorcas J., Cadenhead, Kristin S., Olincy, Ann, Freedman, Robert, Green, Michael F., ...
Background: The Consortium on the Genetics of Schizophrenia (COGS) is an ongoing, National Institute of Mental Health–funded, 7-site collaboration investigating the occurrence and genetic...
Schork, Nicholas J., Greenwood, Tiffany A., Braff, David L.
Statistical genetics is a research field that focuses on mathematical models and statistical inference methodologies that relate genetic variations (ie, naturally occurring human DNA sequence...
Calkins, Monica E., Dobie, Dorcas J., Cadenhead, Kristin S., Olincy, Ann, Freedman, Robert, Green, Michael F., ...
Background: The Consortium on the Genetics of Schizophrenia (COGS) is an ongoing, National Institute of Mental Health-funded, 7-site collaboration investigating the occurrence and genetic...
Schork, Nicholas J., Greenwood, Tiffany A., Braff, David L.
Statistical genetics is a research field that focuses on mathematical models and statistical inference methodologies that relate genetic variations (ie, naturally occurring human DNA sequence...
Braff, David L., Freedman, Robert, Schork, Nicholas J., Gottesman, Irving I.
The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and identify the functional importance of...
Working Memory in Schizophrenia: Transient "Online" Storage Versus Executive Functioning (2001)
Perry, William, Heaton, Robert K., Potterat, Eric, Roebuck, Tresa, Minassian, Arpi, Braff, David L.
Working memory has been described as the temporary “online” storage and the subsequent manipulation and retrieval of information. It has been suggested that the prefrontal cortex is a primary...
Green, Michael Foster, Kern, Robert S., Braff, David L., Mintz, Jim
There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper,...
Neuroanatomy of Schizophrenia (1997)
Braff, David L., Swerdlow, Neal R.
The articles that appear in this issue offer a framework of insights about the neuroanatomy of schizophrenia from three learned and creative perspectives. All three articles advance our understanding...
Information Processing and Attention Dysfunctions in Schizophrenia (1993)
Abnormalities of information processing have played a central role in understanding schizophrenia since the time of Kraepelin and Bleuler. Clearly, schizophrenia spectrum patients have profound...
Sensory Gating and Inhibitory Function in Late-life Schizophrenia (1993)
McDowd, Joan M., Filion, Diane L., Harris, M. Jackuelyn, Braff, David L.
Although similarities between the cognitive deficits observed in schizophrenia and those observed in aging have been recognized for over 50 years, little work has been done to directly examine these...
Reply to Cognitive Therapy and Schizophrenia (1992)
These interesting articles on cognitive deficits and rehabilitation in schizophrenic patients stimulate many questions, two of which are discussed in this reply. First, it seems likely that...
Delusions: A Review and Integration (1991)
Butler, Robert W., Braff, David L.
Delusions are often prominent symptoms in schizophrenia and other psychiatric and neurologic disorders. Despite the central descriptive importance of delusions, there is a paucity of comprehensive...
Startle Habituation and Sensorimotor Gating in Schizophrenia and Related Animal Models (1987)
Geyer, Mark A., Braff, David L.
Studies of the habituation and sensorimotor gating of startle responses to strong exteroceptive stimuli provide some unique opportunities for cross-species explorations into information processing...
Information-processing Abnormalities: Trait- and State-dependent Components (1986)
Saccuzzo, Dennis P., Braff, David L.
Schizophrenics were compared to schizoaffective, bipolar, and nonpsychotic depressed patients in a visual masking paradigm in which an informational target stimulus was followed at varying intervals...
Impaired Speed of Information Processing in Nonmedicated Schizotypal Patients (1981)
There is increasing evidence that schizophrenia is associated with an attentional or information processing deficit or both. These “early deficit” theories challenge the position that...
Swerdlow, Neal R, Geyer, Mark A, Shoemaker, Jody M, Light, Gregory A, Braff, David L, Stevens, Karen E, ...
Prepulse inhibition of startle (‘PPI’), a cross-species measure of sensorimotor gating, is impaired in schizophrenia patients. Suppression of P50 event-related potentials (ERPs) in response to...
Advances in endophenotyping schizophrenia
BRAFF, DAVID L., GREENWOOD, TIFFANY A., SWERDLOW, NEAL R., LIGHT, GREGORY A., SCHORK, NICHOLAS J.
The search for the genetic architecture of schizophrenia has employed multiple, often converging strategies. One such strategy entails the use of tracing the heritability and neurobiology of...
Statistical Genetics Concepts and Approaches in Schizophrenia and Related Neuropsychiatric Research
Schork, Nicholas J., Greenwood, Tiffany A., Braff, David L.
Statistical genetics is a research field that focuses on mathematical models and statistical inference methodologies that relate genetic variations (ie, naturally occurring human DNA sequence...
Braff, David L., Freedman, Robert, Schork, Nicholas J., Gottesman, Irving I.
The genetics of schizophrenia has been approached utilizing a variety of methods. One emerging strategy is the use of endophenotypes in order to understand and identify the functional importance of...
Calkins, Monica E., Dobie, Dorcas J., Cadenhead, Kristin S., Olincy, Ann, Freedman, Robert, Green, Michael F., ...
Background: The Consortium on the Genetics of Schizophrenia (COGS) is an ongoing, National Institute of Mental Health–funded, 7-site collaboration investigating the occurrence and genetic...