David L. Williams

Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism (2008)

Ha, Tuanzhu, Hua, Fang, Liu, Xiang, Ma, Jing, McMullen, Julie R., Shioi, Tetsuo, ...

Aims The ability of lipopolysaccharide (LPS) pre-treatment to induce cardioprotection following ischaemia/reperfusion (I/R) has been well documented; however, the mechanisms have not been fully...

Program Review (2007)

And Investigations Committee, Alice Hobson, Alice Hobson, Robert Sherman, ...

This report has been prepared by the Legislative Research Commission and printed with state funds

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target (2007)

Angela N. Kuntz, Elisabeth Davioud-Charvet, Ahmed A. Sayed, Lindsay L. Califf, Jean Dessolin, ...

BackgroundSchistosomiasis—infection with helminth parasites in the genus Schistosoma, including S. mansoni—is a widespread, devastating tropical disease affecting more than 200 million people. No...

β-(1→3)-D-glucan modulates DNA binding of nuclear factors κB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1β/IL-1 receptor antagonist ratio (2006)

Luhm, Juergen, Langenkamp, Ulrich, Hensel, Jenny, Frohn, Christoph, Brand, Joerg M, Hennig, Holger, ...

Abstract Background β-1→3-D-glucans represent a pathogen-associated molecular pattern and are able to modify biological responses. Employing a comprehensive methodological approach, the aim of our...

Downloaded from (2006)

David L. Williams, John Kalbfleisch, I. William Browder, Race L. Kao, Chuanfu Li, First Published Jun, ...

doi:10.1152/ajpheart.01264.2005 You might find this additional information useful... This article cites 51 articles, 19 of which you can access free at:

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus (2005)

Chad Steele, Rekha R. Rapaka, Allison Metz, Shannon M. Pop, David L. Williams, Siamon Gordon, ...

Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...

RESEARCH ON ORGANIC DEPOLARIZERS. (2005)

Gruber, Bernard A, Williams, David L

Data was collected on the electronic and electrolytic conduction through C/DNB/Mg(C104)2 bobbins, AC and DC conduction measurements were compared with calculated electrolytic resistance, based on...

RESEARCH ON ORGANIC DEPOLARIZERS. (2005)

Gruber, Bernard A., Williams, David L., McElhill, Elizabeth A.

A method is described for determining electronic and ionic conductivities in an organic depolarizer battery bobbin. Preliminary results are reported. This method of determining resistance is compared...

Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload (2005)

Ha, Tuanzhu, Li, Yuehua, Hua, Fang, Ma, Jinag, Gao, Xiang, Kelley, Jim, ...

Objective: We have previously demonstrated that nuclear factor kappa B (NFB) activation is needed for the development of cardiac hypertrophy in vivo. NFB is a downstream transcription factor in the...

Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model (2004)

Mann, Karen M., Thorngate, Fayanne E., Katoh-Fukui, Yuko, Hamanaka, Hiroki, Williams, David L., Fujita, Shinobu, ...

The APOE ϵ4 allele is the most significant genetic risk factor associated with Alzheimer's disease to date. Epidemiological studies have demonstrated that inheritance of one or more ϵ4...

Modulating Toll-like receptor mediated signaling by (1->3)-{beta}-D-glucan rapidly induces cardioprotection (2004)

Li, Chuanfu, Ha, Tuanzhu, Kelley, Jim, Gao, Xiang, Qiu, Yufeng, Kao, Race L, ...

Objective: Immune and inflammatory signaling pathways, initiated by the innate response, are involved in myocardial ischemia/reperfusion (I/R) injury. Toll-like receptor (TLR) mediated...

Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model (2004)

Mann, Karen M., Thorngate, Fayanne E., Katoh-Fukui, Yuko, Hamanaka, Hiroki, Williams, David L., Fujita, Shinobu, ...

The APOE ϵ4 allele is the most significant genetic risk factor associated with Alzheimer's disease to date. Epidemiological studies have demonstrated that inheritance of one or more ϵ4...

Independent effects of APOE on cholesterol metabolism and brain A{beta} levels in an Alzheimer disease mouse model (2004)

Mann, Karen M., Thorngate, Fayanne E., Katoh-Fukui, Yuko, Hamanaka, Hiroki, Williams, David L., Fujita, Shinobu, ...

The APOE ϵ4 allele is the most significant genetic risk factor associated with Alzheimer's disease to date. Epidemiological studies have demonstrated that inheritance of one or more ϵ4...

ARPA Rock Drill Report. (2002)

Davis,Raymond E., Williams,David L., Von Herzen,Richard P.

The report outlines the development and capabilities of the Woods Hole Oceanographic Institution's Rock Core Drill. The Rock Drill is shown to provide a relatively inexpensive means of recovering...

Local Anesthetic Microencapsulation. (2002)

Williams,David L., Nuwayser,Elie S., Kerrigan,James H., Creeden,David E., Nucefora,William A.

Local anesthetics have been microencapsulated using a biodegradable ploymer, polylactids. Lidocaine base and hydrochlorides of lidocaine, etidocaine and bupivacaine were coated with various...

Boudicca, a Retrovirus-Like Long Terminal Repeat Retrotransposon from the Genome of the Human Blood Fluke Schistosoma mansoni (2002)

Claudia S. Copel, Paul J. Brindley, Oliver Heyers, Scott F. Michael, David A. Johnston, David L. Williams, ...

The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...

Post-IPO operating performance of despository institutions, 1992-1998 / (2001)

Williams, David L.

Thesis (Doctor of Business Administration)--Louisiana Tech University, November 2001.

MOLECULAR AND ENZYMATIC CHARACTERIZATION OF SCHISTOSOMA MANSONI THIOREDOXIN PEROXIDASE (2000)

Mark A. Kwatia, Douglas J. Botkin, David L. Williams

The ability of Schistosoma mansoni to escape oxidative damage from immune system-generated reactive oxygen intermediates has been extensively documented. The limiting step in the parasite's...

The influence of glucan polymer structure and solution conformation on binding to (1->3)-{beta}-D-glucan receptors in a human monocyte-like cell line (2000)

Mueller, Antje, Raptis, John, Rice, Peter J., Kalbfleisch, John H., Stout, Robert D., Ensley, Harry E., ...

Glucans are (1–3)-&bgr;-d-linked polymers of glucose that are produced as fungal cell wall constituents and are also released into the extracellular milieu. Glucans modulate immune function via...

Tropical Field Test of a Knitted Paper Sandbag. (1998)

Levine,Sidney, Williams,David L.

Field trials of the knitted paper sandbag (containing an organo-zinc fungicide) and six other sandbag types conducted by the Australian Military Forces in temperate, semi-tropical, and tropical...

LIQUID LASER PARAMETERS. (1998)

Williams, David L., Grafstein, Daniel, Samuel, Aryeh H.

Attempts have been made to extend the calculation of energy-flow diagrams to a series of additional europium(III) complexes. This has led to the appearance of negative rate constants, a physically...

Research and Development of Wound Dressing in Maxillofacial Trauma. (1998)

Williams,David L., Kerrigan,James H.

Three kilograms of poly-L-((-)lactide have been synthesized for this contract and for Contract No. DAMD 17-80-C-0110. This polymer has a viscosity (R.S.V.) of 1.19 dl.g, a molecular weight (MWw) of...

Wound Dressing in Maxillofacial Trauma. (1998)

Williams,David L., Tenney,Barron W., Dillon,James J.

Biodegradable polymers of poly-L(-)lactide (R.S.V. = 0.3 and 1.3 dl/g), poly-DL-lactide and poly(lactide-co-glycolide) were prepared and blended with drugs for use in wound dressings. Three local...

Local Anesthetic Microcapsules. (1998)

Williams,David L., Kerrigan,James H., Nucefora,William A.

Three kilograms of poly-L(-)lactide has been synthesized for this contract and for Contract No. DAMD 17-80-C-0093. This polymer has a viscosity (R.S.V.) of 1.19 dl/g, a molecular weight (MWw) of...

Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy (1998)

Suzuki, Makoto, Ohte, Nobuyuki, Wang, Zhong-Min, Williams, David L., Little, William C., Cheng, Che-Ping

Objective: The positive inotropic effect of endothelin-1 (ET-1) on normal myocardial contraction may be altered in pathological states. The purpose of this study was to assess the direct effect of...

Overview of (1→3)-β-D-glucan immunobiology (1997)

David L. Williams

Glucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In...

Software productivity metrics : an investigation of the strategic value of software metrics to major corporations / (1994)

Williams, David L.

"The software industry needs tools and techniques to effectively estimate and predict costs and on-time delivery of high quality software. The use of software productivity metrics provides the means...

Isolation and characterization of a cDNA clone specific for avian vitellogenin II (1982)

Protter, Andrew A., Wang, Sho-Ya, Shelness, Gregory S., Ostapchuk, Philomena, Williams, David L.

A clone for vitellogenin, a major avian, estrogen responsive egg yolk protein, was isolated from the cDNA library of estrogen-induced rooster liver. Two forms of plasma vitellogenin, vitellogenin I...

Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells

Temel, Ryan E., Trigatti, Bernardo, DeMattos, Ronald B., Azhar, Salman, Krieger, Monty, Williams, David L.

The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured transfected cells. The high levels of...

Schistosome Infection Stimulates Host CD4+ T Helper Cell and B-Cell Responses against a Novel Egg Antigen, Thioredoxin Peroxidase

Williams, David L., Asahi, Hiroko, Botkin, Douglas J., Stadecker, Miguel J.

Egg granuloma formation during schistosome infections is mediated by CD4+ T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown....

Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans

Kougias, Panagiotis, Wei, Duo, Rice, Peter J., Ensley, Harry E., Kalbfleisch, John, Williams, David L., ...

Fungal cell wall glucans nonspecifically stimulate various aspects of innate immunity. Glucans are thought to mediate their effects via interaction with membrane receptors on macrophages,...

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., ...

Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in North America. Current treatments focused on dopamine-replacement strategies ultimately fail in most...

Scavenger Receptor BI (SR-BI) Clustered on Microvillar Extensions Suggests that This Plasma Membrane Domain Is a Way Station for Cholesterol Trafficking between Cells and High-Density Lipoprotein

Peng, Yinan, Akmentin, Wendy, Connelly, Margery A., Lund-Katz, Sissel, Phillips, Michael C., Williams, David L.

Receptor-mediated trafficking of cholesterol between lipoproteins and cells is a fundamental biological process at the organismal and cellular levels. In contrast to the well-studied pathway of LDL...

A simple micro-ELISA method for the assay of antithyroglobulin autoantibodies in human serum

Goodburn, Richard, Williams, David L, Marks, Vincent

An indirect, enzyme-linked immunosorbent assay is described for the assay of thyroid autoantibodies, particularly those directed against thyroglobulin. The method is specific, sensitive and precise,...

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor–BI mediate HDL-initiated signaling

Assanasen, Chatchawin, Mineo, Chieko, Seetharam, Divya, Yuhanna, Ivan S., Marcel, Yves L., Connelly, Margery A., ...

The binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement. HDL also induces multiple cellular signals, which in endothelium occur through SR-BI and converge to activate...

Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

Badawy, Abdulla A.-B., Williams, David L.

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by...

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...

Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...

Boudicca, a Retrovirus-Like Long Terminal Repeat Retrotransposon from the Genome of the Human Blood Fluke Schistosoma mansoni

Copeland, Claudia S., Brindley, Paul J., Heyers, Oliver, Michael, Scott F., Johnston, David A., Williams, David L., ...

The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Netea, Mihai G., Gow, Neil A.R., Munro, Carol A., Bates, Steven, Collins, Claire, Ferwerda, Gerben, ...

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of β-glucans...

Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells

Temel, Ryan E., Trigatti, Bernardo, DeMattos, Ronald B., Azhar, Salman, Krieger, Monty, Williams, David L.

The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured transfected cells. The high levels of...

Schistosome Infection Stimulates Host CD4+ T Helper Cell and B-Cell Responses against a Novel Egg Antigen, Thioredoxin Peroxidase

Williams, David L., Asahi, Hiroko, Botkin, Douglas J., Stadecker, Miguel J.

Egg granuloma formation during schistosome infections is mediated by CD4+ T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown....

Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans

Kougias, Panagiotis, Wei, Duo, Rice, Peter J., Ensley, Harry E., Kalbfleisch, John, Williams, David L., ...

Fungal cell wall glucans nonspecifically stimulate various aspects of innate immunity. Glucans are thought to mediate their effects via interaction with membrane receptors on macrophages,...

Boudicca, a Retrovirus-Like Long Terminal Repeat Retrotransposon from the Genome of the Human Blood Fluke Schistosoma mansoni

Copeland, Claudia S., Brindley, Paul J., Heyers, Oliver, Michael, Scott F., Johnston, David A., Williams, David L., ...

The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., ...

Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in North America. Current treatments focused on dopamine-replacement strategies ultimately fail in most...

Scavenger Receptor BI (SR-BI) Clustered on Microvillar Extensions Suggests that This Plasma Membrane Domain Is a Way Station for Cholesterol Trafficking between Cells and High-Density Lipoprotein

Peng, Yinan, Akmentin, Wendy, Connelly, Margery A., Lund-Katz, Sissel, Phillips, Michael C., Williams, David L.

Receptor-mediated trafficking of cholesterol between lipoproteins and cells is a fundamental biological process at the organismal and cellular levels. In contrast to the well-studied pathway of LDL...

A simple micro-ELISA method for the assay of antithyroglobulin autoantibodies in human serum

Goodburn, Richard, Williams, David L, Marks, Vincent

An indirect, enzyme-linked immunosorbent assay is described for the assay of thyroid autoantibodies, particularly those directed against thyroglobulin. The method is specific, sensitive and precise,...

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor–BI mediate HDL-initiated signaling

Assanasen, Chatchawin, Mineo, Chieko, Seetharam, Divya, Yuhanna, Ivan S., Marcel, Yves L., Connelly, Margery A., ...

The binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement. HDL also induces multiple cellular signals, which in endothelium occur through SR-BI and converge to activate...

Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

Badawy, Abdulla A.-B., Williams, David L.

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by...

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...

Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Netea, Mihai G., Gow, Neil A.R., Munro, Carol A., Bates, Steven, Collins, Claire, Ferwerda, Gerben, ...

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of β-glucans...

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S. J, ...

Using both genetic and biochemical approaches, David Williams and colleagues show that the parasite thioredoxin glutathione reductase meets all the major criteria to be a key target for...

Optical Imaging of Tumor Cells in Hollow Fibers: Evaluation of the Antitumor Activities of Anticancer Drugs and Target Validation

Zhang, Guo-Jun, Chen, Tsing-Bau, Bednar, Bohumil, Connolly, Brett M, Hargreaves, Richard, Sur, Cyrille, ...

The in vivo hollow fiber assay, in which semipermeable hollow fibers filled with tumor cells, are implanted into animals, was originally developed to screen for anticancer compounds before assessment...

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Simeonov, Anton, Jadhav, Ajit, Sayed, Ahmed A., Wang, Yuhong, Nelson, Michael E., Thomas, Craig J., ...

Schistosomiasis is a tropical disease associated with high morbidity and mortality, currently affecting over 200 million people worldwide. Praziquantel is the only drug used to treat the disease, and...

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

Brown, Gordon D., Taylor, Philip R., Reid, Delyth M., Willment, Janet A., Williams, David L., Martinez-Pomares, Luisa, ...

Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and...

Dectin-1 Mediates the Biological Effects of β-Glucans

Brown, Gordon D., Herre, Jurgen, Williams, David L., Willment, Janet A., Marshall, Andrew S. J., Gordon, Siamon

The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized...

Overview of (1→3)-β-D-glucan immunobiology

Williams, David L.

Glucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In...

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Gαi proteins

Fan, Hongkuan, Williams, David L, Zingarelli, Basilia, Breuel, Kevin F, Teti, Giuseppe, Tempel, George E, ...

Heterotrimeric Gi proteins play a role in signalling activated by lipopolysaccharide (LPS), Staphylococcus aureus (SA) and group B streptococci (GBS), leading to production of inflammatory mediators....

Dendritic Cell Interaction with Candida albicans Critically Depends on N-Linked Mannan*S⃞

Cambi, Alessandra, Netea, Mihai G., Mora-Montes, Hector M., Gow, Neil A. R., Hato, Stanleyson V., Lowman, Douglas W., ...

The fungus Candida albicans is the most common cause of mycotic infections in immunocompromised hosts. Little is known about the initial interactions between Candida and immune cell receptors,...

Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors

Dennehy, Kevin M, Ferwerda, Gerben, Faro-Trindade, Inês, Pyż, Elwira, Willment, Janet A, Taylor, Philip R, ...

Recognition of microbial components by germ-line encoded pattern recognition receptors (PRR) initiates immune responses to infectious agents. We and others have proposed that pairs or sets of PRR...

Internalization of Dectin-1 terminates induction of inflammatory responses

Hernanz-Falcón, Patricia, Joffre, Olivier, Williams, David L, Reis E Sousa, Caetano

Dectin-1 is a pattern-recognition receptor recognizing β-(1,3)-glucans found on fungal cell walls. Dectin-1 plays an important role in immunity to fungi by mediating phagocytic clearance of fungal...

The CD5 ectodomain interacts with conserved fungal cell wall components and protects from zymosan-induced septic shock-like syndrome

Vera, Jorge, Fenutría, Rafael, Cañadas, Olga, Figueras, Maite, Mota, Rubén, Sarrias, Maria-Rosa, ...

The CD5 lymphocyte surface receptor is a group B member of the ancient and highly conserved scavenger receptor cysteine-rich superfamily. CD5 is expressed on mature T and B1a cells, where it is known...