David L. Williams

MOLECULAR AND ENZYMATIC CHARACTERIZATION OF SCHISTOSOMA MANSONI THIOREDOXIN PEROXIDASE (2000)

Thesis (Doctor of Business Administration)--Louisiana Tech University, November 2001.

Mark A. Kwatia, Douglas J. Botkin, David L. Williams

The ability of Schistosoma mansoni to escape oxidative damage from immune system-generated reactive oxygen intermediates has been extensively documented. The limiting step in the parasite's...

The influence of glucan polymer structure and solution conformation on binding to (1->3)-{beta}-D-glucan receptors in a human monocyte-like cell line (2000)

Mueller, Antje, Raptis, John, Rice, Peter J., Kalbfleisch, John H., Stout, Robert D., Ensley, Harry E., ...

Glucans are (1–3)-&bgr;-d-linked polymers of glucose that are produced as fungal cell wall constituents and are also released into the extracellular milieu. Glucans modulate immune function via...

Tropical Field Test of a Knitted Paper Sandbag. (1998)

Levine,Sidney, Williams,David L.

Field trials of the knitted paper sandbag (containing an organo-zinc fungicide) and six other sandbag types conducted by the Australian Military Forces in temperate, semi-tropical, and tropical...

LIQUID LASER PARAMETERS. (1998)

Williams, David L., Grafstein, Daniel, Samuel, Aryeh H.

Attempts have been made to extend the calculation of energy-flow diagrams to a series of additional europium(III) complexes. This has led to the appearance of negative rate constants, a physically...

Research and Development of Wound Dressing in Maxillofacial Trauma. (1998)

Williams,David L., Kerrigan,James H.

Three kilograms of poly-L-((-)lactide have been synthesized for this contract and for Contract No. DAMD 17-80-C-0110. This polymer has a viscosity (R.S.V.) of 1.19 dl.g, a molecular weight (MWw) of...

Wound Dressing in Maxillofacial Trauma. (1998)

Williams,David L., Tenney,Barron W., Dillon,James J.

Biodegradable polymers of poly-L(-)lactide (R.S.V. = 0.3 and 1.3 dl/g), poly-DL-lactide and poly(lactide-co-glycolide) were prepared and blended with drugs for use in wound dressings. Three local...

Local Anesthetic Microcapsules. (1998)

Williams,David L., Kerrigan,James H., Nucefora,William A.

Three kilograms of poly-L(-)lactide has been synthesized for this contract and for Contract No. DAMD 17-80-C-0093. This polymer has a viscosity (R.S.V.) of 1.19 dl/g, a molecular weight (MWw) of...

Altered inotropic response of endothelin-1 in cardiomyocytes from rats with isoproterenol-induced cardiomyopathy (1998)

Suzuki, Makoto, Ohte, Nobuyuki, Wang, Zhong-Min, Williams, David L., Little, William C., Cheng, Che-Ping

Objective: The positive inotropic effect of endothelin-1 (ET-1) on normal myocardial contraction may be altered in pathological states. The purpose of this study was to assess the direct effect of...

Overview of (1→3)-β-D-glucan immunobiology (1997)

David L. Williams

Glucans are (1→3)-β-D-glucose polymers that are found in the cell wall of fungi, bacteria and plants. Glucans are known to stim ulate humoral and cell-mediated immunity in humans and animals. In...

Mental health reform proposals within President Clinton's Health Security Act and representative Cooper's Managed Competition Act /--a thesis in healthcare management prepared for the Committee on Credentials ... by David L. Williams. (1994)

Software productivity metrics : an investigation of the strategic value of software metrics to major corporations / (1994)

Thesis (ACHE)--American College of Healthcare Executives, 1994.

RNase H/oligonucleotide-directed mRNA purification (ROMP) of apoll mRNA (1993)

"The software industry needs tools and techniques to effectively estimate and predict costs and on-time delivery of high quality software. The use of software productivity metrics provides the means...

MacDonald, Clinton C., Williams, David L.

Isolation and characterization of a cDNA clone specific for avian vitellogenin II (1982)

Protter, Andrew A., Wang, Sho-Ya, Shelness, Gregory S., Ostapchuk, Philomena, Williams, David L.

A clone for vitellogenin, a major avian, estrogen responsive egg yolk protein, was isolated from the cDNA library of estrogen-induced rooster liver. Two forms of plasma vitellogenin, vitellogenin I...

The inter-relation of school and community as seen in Greenwood School District, Jefferson County Kentucky /--by David L. Williams. (1952)

Inman, Clarissa McKeys, House (Portland, Oregon) (1926)

Typescript.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior

Inman, Clarissa McKeys, House (Portland, Oregon) (1926)

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: dining room, looking south

Inman, Clarissa McKeys, House (Portland, Oregon) (1926)

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: east facade, portico detail.

Inman, Clarissa McKeys, House (Portland, Oregon) (1926)

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: east facade, window detail.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: general view from street

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view of entry porch.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view of front facade.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: close-up, entry porch.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view of right facade.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view of left facade.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view of rear facade.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: detail, window.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: garage, right facade.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: entry hall/staircase

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: bay, stained glass window.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: close-up, stained glass.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: dining room view to entry.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: view of living room

David Lockhead Williams (architect, 1866-1937), Williams, David L.

interior: view of dining room

David L. Williams (architect), Williams, David L., Marion Dean Ross

exterior

David L. Williams (architect), Williams, David L., Angelus Photo

exterior

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: view northeast.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: north elevation

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: east elevation

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: west elevation

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: south elevation

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: gate.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: south elevation, entrance.

David Lockhead Williams (architect, 1866-1937), Williams, David L.

exterior: south elevation garden seat.

Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells

Temel, Ryan E., Trigatti, Bernardo, DeMattos, Ronald B., Azhar, Salman, Krieger, Monty, Williams, David L.

The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured transfected cells. The high levels of...

Schistosome Infection Stimulates Host CD4+ T Helper Cell and B-Cell Responses against a Novel Egg Antigen, Thioredoxin Peroxidase

Williams, David L., Asahi, Hiroko, Botkin, Douglas J., Stadecker, Miguel J.

Egg granuloma formation during schistosome infections is mediated by CD4+ T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown....

Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans

Kougias, Panagiotis, Wei, Duo, Rice, Peter J., Ensley, Harry E., Kalbfleisch, John, Williams, David L., ...

Fungal cell wall glucans nonspecifically stimulate various aspects of innate immunity. Glucans are thought to mediate their effects via interaction with membrane receptors on macrophages,...

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., ...

Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in North America. Current treatments focused on dopamine-replacement strategies ultimately fail in most...

Scavenger Receptor BI (SR-BI) Clustered on Microvillar Extensions Suggests that This Plasma Membrane Domain Is a Way Station for Cholesterol Trafficking between Cells and High-Density Lipoprotein

Peng, Yinan, Akmentin, Wendy, Connelly, Margery A., Lund-Katz, Sissel, Phillips, Michael C., Williams, David L.

Receptor-mediated trafficking of cholesterol between lipoproteins and cells is a fundamental biological process at the organismal and cellular levels. In contrast to the well-studied pathway of LDL...

A simple micro-ELISA method for the assay of antithyroglobulin autoantibodies in human serum

Goodburn, Richard, Williams, David L, Marks, Vincent

An indirect, enzyme-linked immunosorbent assay is described for the assay of thyroid autoantibodies, particularly those directed against thyroglobulin. The method is specific, sensitive and precise,...

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor–BI mediate HDL-initiated signaling

Assanasen, Chatchawin, Mineo, Chieko, Seetharam, Divya, Yuhanna, Ivan S., Marcel, Yves L., Connelly, Margery A., ...

The binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement. HDL also induces multiple cellular signals, which in endothelium occur through SR-BI and converge to activate...

Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

Badawy, Abdulla A.-B., Williams, David L.

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by...

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...

Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...

Boudicca, a Retrovirus-Like Long Terminal Repeat Retrotransposon from the Genome of the Human Blood Fluke Schistosoma mansoni

Copeland, Claudia S., Brindley, Paul J., Heyers, Oliver, Michael, Scott F., Johnston, David A., Williams, David L., ...

The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...

Early Activation of Hepatic NFκB and NF-IL6 in Polymicrobial Sepsis Correlates With Bacteremia, Cytokine Expression, and Mortality

Williams, David L., Ha, Tuanzhu, Li, Chuanfu, Kalbfleisch, John H., Ferguson, Donald A.

β-(1→3)-D-glucan modulates DNA binding of nuclear factors κB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1β/IL-1 receptor antagonist ratio

Luhm, Juergen, Langenkamp, Ulrich, Hensel, Jenny, Frohn, Christoph, Brand, Joerg M, Hennig, Holger, ...

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Netea, Mihai G., Gow, Neil A.R., Munro, Carol A., Bates, Steven, Collins, Claire, Ferwerda, Gerben, ...

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of β-glucans...

In aid of doctors suffering from complaints about AIDS

Doctors, drugs, and the DHSS

Deputising services

Index-linked pensions

Distinction Awards

“Specialist” and hospital practitioner grades

Scavenger receptor class B, type I (SR-BI) is the major route for the delivery of high density lipoprotein cholesterol to the steroidogenic pathway in cultured mouse adrenocortical cells

Temel, Ryan E., Trigatti, Bernardo, DeMattos, Ronald B., Azhar, Salman, Krieger, Monty, Williams, David L.

The class B, type I scavenger receptor, SR-BI, binds high density lipoprotein (HDL) and mediates the selective uptake of HDL cholesteryl ester (CE) by cultured transfected cells. The high levels of...

Schistosome Infection Stimulates Host CD4+ T Helper Cell and B-Cell Responses against a Novel Egg Antigen, Thioredoxin Peroxidase

Williams, David L., Asahi, Hiroko, Botkin, Douglas J., Stadecker, Miguel J.

Egg granuloma formation during schistosome infections is mediated by CD4+ T helper (Th) cells sensitized to egg antigens; however, most of the relevant sensitizing egg antigens are still unknown....

Normal Human Fibroblasts Express Pattern Recognition Receptors for Fungal (1→3)-β-d-Glucans

Kougias, Panagiotis, Wei, Duo, Rice, Peter J., Ensley, Harry E., Kalbfleisch, John, Williams, David L., ...

Fungal cell wall glucans nonspecifically stimulate various aspects of innate immunity. Glucans are thought to mediate their effects via interaction with membrane receptors on macrophages,...

Boudicca, a Retrovirus-Like Long Terminal Repeat Retrotransposon from the Genome of the Human Blood Fluke Schistosoma mansoni

Copeland, Claudia S., Brindley, Paul J., Heyers, Oliver, Michael, Scott F., Johnston, David A., Williams, David L., ...

The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated Boudicca. Sequence and structural characterization of the new...

Allosteric modulation of group III metabotropic glutamate receptor 4: A potential approach to Parkinson's disease treatment

Marino, Michael J., Williams, David L., O'Brien, Julie A., Valenti, Ornella, McDonald, Terrence P., Clements, Michelle K., ...

Parkinson's disease (PD) is a debilitating movement disorder that afflicts >1 million people in North America. Current treatments focused on dopamine-replacement strategies ultimately fail in most...

Scavenger Receptor BI (SR-BI) Clustered on Microvillar Extensions Suggests that This Plasma Membrane Domain Is a Way Station for Cholesterol Trafficking between Cells and High-Density Lipoprotein

Peng, Yinan, Akmentin, Wendy, Connelly, Margery A., Lund-Katz, Sissel, Phillips, Michael C., Williams, David L.

Receptor-mediated trafficking of cholesterol between lipoproteins and cells is a fundamental biological process at the organismal and cellular levels. In contrast to the well-studied pathway of LDL...

A simple micro-ELISA method for the assay of antithyroglobulin autoantibodies in human serum

Goodburn, Richard, Williams, David L, Marks, Vincent

An indirect, enzyme-linked immunosorbent assay is described for the assay of thyroid autoantibodies, particularly those directed against thyroglobulin. The method is specific, sensitive and precise,...

Cholesterol binding, efflux, and a PDZ-interacting domain of scavenger receptor–BI mediate HDL-initiated signaling

Assanasen, Chatchawin, Mineo, Chieko, Seetharam, Divya, Yuhanna, Ivan S., Marcel, Yves L., Connelly, Margery A., ...

The binding of HDL to scavenger receptor–BI (SR-BI) mediates cholesterol movement. HDL also induces multiple cellular signals, which in endothelium occur through SR-BI and converge to activate...

Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

Badawy, Abdulla A.-B., Williams, David L.

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by...

The Beta-Glucan Receptor Dectin-1 Recognizes Specific Morphologies of Aspergillus fumigatus

Steele, Chad, Rapaka, Rekha R, Metz, Allison, Pop, Shannon M, Williams, David L, Gordon, Siamon, ...

Alveolar macrophages represent a first-line innate host defense mechanism for clearing inhaled Aspergillus fumigatus from the lungs, yet contradictory data exist as to which alveolar macrophage...

In aid of doctors suffering from complaints about AIDS

Doctors, drugs, and the DHSS

Early Activation of Hepatic NFκB and NF-IL6 in Polymicrobial Sepsis Correlates With Bacteremia, Cytokine Expression, and Mortality

Williams, David L., Ha, Tuanzhu, Li, Chuanfu, Kalbfleisch, John H., Ferguson, Donald A.

Deputising services

Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors

Netea, Mihai G., Gow, Neil A.R., Munro, Carol A., Bates, Steven, Collins, Claire, Ferwerda, Gerben, ...

The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of β-glucans...

β-(1→3)-D-glucan modulates DNA binding of nuclear factors κB, AT and IL-6 leading to an anti-inflammatory shift of the IL-1β/IL-1 receptor antagonist ratio

Luhm, Juergen, Langenkamp, Ulrich, Hensel, Jenny, Frohn, Christoph, Brand, Joerg M, Hennig, Holger, ...

Index-linked pensions

Distinction Awards

“Specialist” and hospital practitioner grades

Nursing services in general practice

Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S. J, ...

Using both genetic and biochemical approaches, David Williams and colleagues show that the parasite thioredoxin glutathione reductase meets all the major criteria to be a key target for...

Correction: Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target

Kuntz, Angela N, Davioud-Charvet, Elisabeth, Sayed, Ahmed A, Califf, Lindsay L, Dessolin, Jean, Arnér, Elias S. J, ...

Optical Imaging of Tumor Cells in Hollow Fibers: Evaluation of the Antitumor Activities of Anticancer Drugs and Target Validation

Zhang, Guo-Jun, Chen, Tsing-Bau, Bednar, Bohumil, Connolly, Brett M, Hargreaves, Richard, Sur, Cyrille, ...

The in vivo hollow fiber assay, in which semipermeable hollow fibers filled with tumor cells, are implanted into animals, was originally developed to screen for anticancer compounds before assessment...

Clinical Responsibility

Clinical Responsibility

Area Health Boards

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

Simeonov, Anton, Jadhav, Ajit, Sayed, Ahmed A., Wang, Yuhong, Nelson, Michael E., Thomas, Craig J., ...

Schistosomiasis is a tropical disease associated with high morbidity and mortality, currently affecting over 200 million people worldwide. Praziquantel is the only drug used to treat the disease, and...

The pathology of family life

Dectin-1 Is A Major β-Glucan Receptor On Macrophages

Brown, Gordon D., Taylor, Philip R., Reid, Delyth M., Willment, Janet A., Williams, David L., Martinez-Pomares, Luisa, ...

Zymosan is a β-glucan– and mannan-rich particle that is widely used as a cellular activator for examining the numerous responses effected by phagocytes. The macrophage mannose receptor (MR) and...

Dectin-1 Mediates the Biological Effects of β-Glucans

Brown, Gordon D., Herre, Jurgen, Williams, David L., Willment, Janet A., Marshall, Andrew S. J., Gordon, Siamon

The ability of fungal-derived β-glucan particles to induce leukocyte activation and the production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well characterized...

Overview of (1→3)-β-D-glucan immunobiology