David M. Kaye

Diagnostic performance of multisequential cardiac magnetic resonance imaging in acute cardiac allograft rejection (2010)

Taylor, Andrew J., Vaddadi, Gautam, Pfluger, Heinz, Butler, Michelle, Bergin, Peter, Leet, Angeline, ...

Aims We evaluated cardiac magnetic resonance imaging (CMR) as a non-invasive test for cardiac allograft rejection. Methods and results We performed CMR on 50 heart-transplant recipients. Acute...

Improvement in cardiac adrenergic function post biventricular pacing for heart failure (2007)

Gould, Paul A., Kong, Grace, Kalff, Victor, Duffy, Stephen J., Taylor, Andrew J., Kelly, Michael J., ...

Aims We investigated whether biventricular (BiV) pacing favourably affects cardiac sympathetic activity in heart failure (HF). Methods and results In 10 HF patients treated with BiV pacing, we...

Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes (2006)

Laskowski, Adrienne, Woodman, Owen L., Cao, Anh H., Drummond, Grant R., Marshall, Tanneale, Kaye, David M., ...

Objective: Reactive oxygen species (ROS) such as superoxide have been linked to the hypertrophic response of the heart to stimuli including angiotensin II (AngII), mechanical stretch, and pressure...

Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure (2005)

Gould, Paul A., Yii, Michael, Esler, Murray D., Power, John M., Kaye, David M.

Aims In this study, we investigated for a potential mechanism by which atrial fibrillation (AF) might convey a worse prognosis in congestive heart failure (CHF). Specifically, we aimed to determine...

Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure (2005)

Gould, Paul A., Yii, Michael, Esler, Murray D., Power, John M., Kaye, David M.

Aims In this study, we investigated for a potential mechanism by which atrial fibrillation (AF) might convey a worse prognosis in congestive heart failure (CHF). Specifically, we aimed to determine...

Atrial fibrillation impairs cardiac sympathetic response to baroreceptor unloading in congestive heart failure (2005)

Gould, Paul A., Yii, Michael, Esler, Murray D., Power, John M., Kaye, David M.

Aims In this study, we investigated for a potential mechanism by which atrial fibrillation (AF) might convey a worse prognosis in congestive heart failure (CHF). Specifically, we aimed to determine...

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship (2003)

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F., ...

x-Conopeptide MrIA (-MrIA) is a 13-residue peptide contained in the venom of the predatory marine snail Conus marmoreus that has been found to inhibit the norepinephrine transporter (NET). We...

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship (2003)

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F., ...

x-Conopeptide MrIA (-MrIA) is a 13-residue peptide contained in the venom of the predatory marine snail Conus marmoreus that has been found to inhibit the norepinephrine transporter (NET). We...

Chronic atrial fibrillation does not influence the magnitude of sympathetic overactivity in patients with heart failure (2003)

Gould, Paul A, Esler, Murray D, Kaye, David M

Aims In this study we sought to assess the influence of atrial fibrillation (AF) on sympathetic nervous system overactivity in congestive heart failure (CHF) patients. Methods and results We studied...

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship (2003)

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F., ...

x-Conopeptide MrIA (-MrIA) is a 13-residue peptide contained in the venom of the predatory marine snail Conus marmoreus that has been found to inhibit the norepinephrine transporter (NET). We...

Inhibition of the Norepinephrine Transporter by the Venom Peptide {chi}-MrIA: SITE OF ACTION, Na+ dependence, and structure-activity relationship (2003)

Sharpe, Iain A., Palant, Elka, Schroeder, Christina I., Kaye, David M., Adams, David J., Alewood, Paul F., ...

x-Conopeptide MrIA (-MrIA) is a 13-residue peptide contained in the venom of the predatory marine snail Conus marmoreus that has been found to inhibit the norepinephrine transporter (NET). We...

Sympathetic nervous dysfunction in severe heart failure and heart transplantation (1993)

Kaye, David M.

Submitted to the Faculty of Medicine for the degree of Doctor of Philosophy. Summary: leaves v-viii. Typescript. Includes bibliographical references [unpaged] at end of text.

Sympathetic nervous dysfunction in severe heart failure and heart transplantation (1993)

Kaye, David M.

Submitted to the Faculty of Medicine for the degree of Doctor of Philosophy. Summary: leaves v-viii. Typescript. Includes bibliographical references [unpaged] at end of text.

Impaired contraction and relaxation in skin resistance arteries from patients with congestive heart failure (1993)

Angus, James A, Ferrier, Claudia P, Sudhir, Krishnankutty, Kaye, David M, Jennings, Garry L

Objective: The aim was to determine the pharmacological reactivity of human small resistance arteries in patients with cardiac failure. Methods: Small arteries (

Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter

Percy, Elodie, Kaye, David M, Lambert, Gavin W, Gruskin, Sara, Esler, Murray D, Du, Xiao-Jun

We examined the existence of catecholamine metabolizing enzymes (catechol-O-methyltransferase, COMT, and monoamine oxidase, MAO) in CHO cells transfected with norepinephrine (NE) transporter (NET)...

Nitric oxide mediated modulation of norepinephrine transport: identification of a potential target for S-nitrosylation

Kaye, David M, Gruskin, Sara, Smith, A Ian, Esler, Murray D

Carrier mediated uptake (uptake-1) transport of norepinephrine (NE) plays a key role in the regulation of sympathetic neurotransmission. Recent investigations indicate that nitric oxide (NO) may...