Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 (2009)
Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., ...
p21 transcription is regulated by differential localization of histone H2A.Z (2007)
Gévry, Nicolas, Chan, Ho Man, Laflamme, Liette, Livingston, David M., Gaudreau, Luc
In yeast cells, H2A.Z regulates transcription and is globally associated within a few nucleosomes of the initiator regions of numerous promoters. H2A.Z is deposited at these loci by an ATP-dependent...
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
The p400 E1A-associated protein is a novel component of the p53 -> p21 senescence pathway (2005)
Chan, Ho Man, Narita, Masako, Lowe, Scott W., Livingston, David M.
Adenovirus E1A-associated p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Here, we report that p400 is a component of the p53–p21WAF1/CIP1/sid1 pathway, regulating the p21...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
Cantor, Sharon B., Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Cantor, Sharon B., Bell, Daphne W., Ganesan, Shridar, Kass, Elizabeth M., Drapkin, Ronny, Grossman, Steven R., ...
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. A BACH1 derivative, bearing a mutation in a residue that...
Outer space commerce : its history and prospects / (2001)
Thesis (Ph. D.)--Golden Gate University, 2001.
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP (2000)
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway (1999)
Chen, Junjie, Silver, Daniel P., Cantor, Sharon B., Livingston, David M., Scully, Ralph
The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 (1999)
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Cell Cycle Analysis of the BRCA1 Gene Product (1998)
Livingston, David M., Lynch, Dennis
During the past 12 months, our laboratory has made significant progress in the tasks of this application related to the discovery of specific BRCA1 interacting proteins. We have discovered that BRCA2...
Understanding Endogenous c-Myc Function in Human Breast Cancer Development (1998)
Xia, Bing, Livingston, David M.
My research is focused on BRCA2, whose mutation has been implicated in the development of breast, ovarian, prostate, pancreatic cancers and Fanconi anemia BRCA2 is an extremely large protein that is...
Functional Study of the Human BRCA2 Tumor Suppressor (1998)
Xia, Bing, Livingston, David M.
My research is focused on the BRCA2 protein, whose mutations have been implicated in the development of breast, ovarian, male breast, prostate, pancreatic cancers and Fanconi anemia. It is intended...
Functional Study of the Human BRCA2 Tumor Suppressor (1998)
Xia, Bing, Livingston, David M.
My research is focused on the BRCA2 protein, whose mutations have been implicated in the development of breast, ovarian, male breast, prostate, pancreatic cancers and Fanconi anemia. It is intended...
Chen, Junjie, Silver, Daniel P., Walpita, Deepika, Cantor, Sharon B., Gazdar, Adi F., Tomlinson, Gail, ...
BRCA1 and BRCA2 account for most cases of familial, early onset breast and/or ovarian cancer and encode products that each interact with hRAD51. Results presented here show that BRCA1 and BRCA2...
Lindeman, Geoffrey J., Dagnino, Lina, Gaubatz, Stefan, Xu, Yuhui, Bronson, Roderick T., Warren, Henry B., ...
Ewen, Mark E., Xing, Yigong P., Lawrence, Jeanne B., Livingston, David M.
p107 is a cellular protein that forms specific complexes with adenovirus E1A and SV40 large T antigen (T). The genetics of the p107-T/E1A interaction as well as other features of this protein...
Regulation of endogenous E2F1 stability by the retinoblastoma family proteins
Martelli, Fabio, Livingston, David M.
Certain E2F transcription factor species play a pivotal role in regulating cell-cycle progression. The activity of E2F1, a protein with neoplastic transforming activity when unregulated, is tightly...
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, Ralph, Anderson, Stephen F., Chao, David M., Wei, Wanjiang, Ye, Liyan, Young, Richard A., ...
The familial breast–ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme...
Gaubatz, Stefan, Wood, Jason G., Livingston, David M.
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6...
The subcellular localization of E2F-4 is cell-cycle dependent
Lindeman, Geoffrey J., Gaubatz, Stefan, Livingston, David M., Ginsberg, Doron
The E2F family of transcription factors plays a crucial role in cell cycle progression. E2F activity is tightly regulated by a number of mechanisms, which include the timely synthesis and degradation...
Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts
Wang, Zhiyan M., Yang, Hong, Livingston, David M.
Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G0/G1. Results described here provide direct evidence that endogenous E2F-1, as predicted,...
p19ARF targets certain E2F species for degradation
Martelli, Fabio, Hamilton, Timothy, Silver, Daniel P., Sharpless, Norman E., Bardeesy, Nabeel, Rokas, Mihail, ...
p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism. p19ARF was found to complex with transcription factors E2F1, -2, and -3. Levels of endogenous or ectopically expressed...
Joukov, Vladimir, Chen, Junjie, Fox, Edward A., Green, Jeremy B. A., Livingston, David M.
The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in...
E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner
Gaubatz, Stefan, Lees, Jacqueline A., Lindeman, Geoffrey J., Livingston, David M.
E2F is a family of transcription factors required for normal cell cycle control and for cell cycle arrest in G1. E2F4 is the most abundant E2F protein in many cell types. In quiescent cells, it is...
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, ...
Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the...
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., ...
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To...
Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein
Yang, Hong, Williams, Bart O., Hinds, Phillip W., Shih, T. Shane, Jacks, Tyler, Bronson, Roderick T., ...
Rb+/+:Rb−/− chimeric mice are healthy until early in adulthood when they develop lethal pituitary tumors composed solely of Rb−/− cells. In an effort to delineate the minimal structures of...
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
Rebel, Vivienne I., Kung, Andrew L., Tanner, Elizabeth A., Yang, Hong, Bronson, Roderick T., Livingston, David M.
Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional...
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1α. A new...
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
Lindeman, Geoffrey J., Dagnino, Lina, Gaubatz, Stefan, Xu, Yuhui, Bronson, Roderick T., Warren, Henry B., ...
Homozygous E2F-5 knockout embryos and mice have been generated. Although embryonic development appeared normal, newborn mice developed nonobstructive hydrocephalus, suggesting excessive cerebrospinal...
Cantor, Sharon, Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...
Taubert, Stefan, Gorrini, Chiara, Frank, Scott R., Parisi, Tiziana, Fuchs, Miriam, Chan, Ho-Man, ...
E2F proteins can either activate or repress transcription. Following mitogenic stimulation, repressive E2F4-p130-histone deacetylase complexes dissociate from, while activating species (E2F1, -2, and...
Livingston, David M., Scolnick, Edward M., Parks, Wade P., Todaro, George J.
A solid phase immunoadsorbent specific for RNA-dependent DNA polymerase from murine and feline RNA tumor viruses has been prepared. The enzymes from murine and feline virus but not from avian virus...
The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway
Chan, Ho Man, Narita, Masako, Lowe, Scott W., Livingston, David M.
Adenovirus E1A-associated p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Here, we report that p400 is a component of the p53–p21WAF1/CIP1/sid1 pathway, regulating the p21...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6
Storre, Jörg, Elsässer, Hans-Peter, Fuchs, Miriam, Ullmann, Diana, Livingston, David M., Gaubatz, Stefan
E2F transcription factors play an important role in regulating mammalian cell proliferation. E2F6, the most recently identified E2F family member, is a transcriptional repressor. In an effort to...
MYC recruits the TIP60 histone acetyltransferase complex to chromatin
Frank, Scott R., Parisi, Tiziana, Taubert, Stefan, Fernandez, Paula, Fuchs, Miriam, Chan, Ho-Man, ...
The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H3 and H4. However, the histone acetyltransferases (HATs) that are responsible for...
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Brca1 C-terminal (BRCT) domains are a common protein–protein interaction motif in proteins involved in the DNA damage response and DNA repair. The DNA-damage response protein 53BP1 has two BRCT...
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Regulation of endogenous E2F1 stability by the retinoblastoma family proteins
Martelli, Fabio, Livingston, David M.
Certain E2F transcription factor species play a pivotal role in regulating cell-cycle progression. The activity of E2F1, a protein with neoplastic transforming activity when unregulated, is tightly...
BRCA1 is a component of the RNA polymerase II holoenzyme
Scully, Ralph, Anderson, Stephen F., Chao, David M., Wei, Wanjiang, Ye, Liyan, Young, Richard A., ...
The familial breast–ovarian tumor suppressor gene product BRCA1 was found to be a component of the RNA polymerase II holoenzyme by several criteria. BRCA1 was found to copurify with the holoenzyme...
Gaubatz, Stefan, Wood, Jason G., Livingston, David M.
E2F transcription factors play an important role in the regulation of cell cycle progression. We report here the cloning and characterization of an additional member of this family, E2F-6. E2F-6...
The subcellular localization of E2F-4 is cell-cycle dependent
Lindeman, Geoffrey J., Gaubatz, Stefan, Livingston, David M., Ginsberg, Doron
The E2F family of transcription factors plays a crucial role in cell cycle progression. E2F activity is tightly regulated by a number of mechanisms, which include the timely synthesis and degradation...
Endogenous E2F-1 promotes timely G0 exit of resting mouse embryo fibroblasts
Wang, Zhiyan M., Yang, Hong, Livingston, David M.
Much evidence strongly suggests a positive role for one or more E2F species in the control of exit from G0/G1. Results described here provide direct evidence that endogenous E2F-1, as predicted,...
p19ARF targets certain E2F species for degradation
Martelli, Fabio, Hamilton, Timothy, Silver, Daniel P., Sharpless, Norman E., Bardeesy, Nabeel, Rokas, Mihail, ...
p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism. p19ARF was found to complex with transcription factors E2F1, -2, and -3. Levels of endogenous or ectopically expressed...
Joukov, Vladimir, Chen, Junjie, Fox, Edward A., Green, Jeremy B. A., Livingston, David M.
The breast and ovarian susceptibility protein 1 (BRCA1) heterodimerizes with its structural relative, the BRCA1-associated RING domain protein (BARD1), which may have tumor suppressing function in...
E2F4 Is Exported from the Nucleus in a CRM1-Dependent Manner
Gaubatz, Stefan, Lees, Jacqueline A., Lindeman, Geoffrey J., Livingston, David M.
E2F is a family of transcription factors required for normal cell cycle control and for cell cycle arrest in G1. E2F4 is the most abundant E2F protein in many cell types. In quiescent cells, it is...
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
Freedman, Steven J., Sun, Zhen-Yu J., Poy, Florence, Kung, Andrew L., Livingston, David M., Wagner, Gerhard, ...
Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the...
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Bassing, Craig H., Chua, Katrin F., Sekiguchi, JoAnn, Suh, Heikyung, Whitlow, Scott R., Fleming, James C., ...
In mammalian cells, DNA double-strand breaks (DSBs) cause rapid phosphorylation of the H2AX core histone variant (to form γ-H2AX) in megabase chromatin domains flanking sites of DNA damage. To...
Tumor Suppression by a Severely Truncated Species of Retinoblastoma Protein
Yang, Hong, Williams, Bart O., Hinds, Phillip W., Shih, T. Shane, Jacks, Tyler, Bronson, Roderick T., ...
Rb+/+:Rb−/− chimeric mice are healthy until early in adulthood when they develop lethal pituitary tumors composed solely of Rb−/− cells. In an effort to delineate the minimal structures of...
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
Rebel, Vivienne I., Kung, Andrew L., Tanner, Elizabeth A., Yang, Hong, Bronson, Roderick T., Livingston, David M.
Hematopoietic stem cells (HSC) are tightly regulated through, as yet, undefined mechanisms that balance self-renewal and differentiation. We have identified a role for the transcriptional...
Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure
Joo, Woo S., Jeffrey, Philip D., Cantor, Sharon B., Finnin, Michael S., Livingston, David M., Pavletich, Nikola P.
Brca1 C-terminal (BRCT) domains are a common protein–protein interaction motif in proteins involved in the DNA damage response and DNA repair. The DNA-damage response protein 53BP1 has two BRCT...
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP
Kung, Andrew L., Rebel, Vivienne I., Bronson, Roderick T., Ch'ng, Lian-Ee, Sieff, Colin A., Livingston, David M., ...
Mice with monoallelic inactivation of the CBP gene develop highly penetrant, multilineage defects in hematopoietic differentiation and, with advancing age, an increased incidence of hematologic...
Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1
Bhattacharya, Shoumo, Michels, Catherine L., Leung, Man-Kit, Arany, Zoltàn P., Kung, Andrew L., Livingston, David M.
Recruitment of p300/CBP by the hypoxia-inducible factor, HIF-1, is essential for the transcriptional response to hypoxia and requires an interaction between the p300/CBP CH1 region and HIF-1α. A new...
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
Lindeman, Geoffrey J., Dagnino, Lina, Gaubatz, Stefan, Xu, Yuhui, Bronson, Roderick T., Warren, Henry B., ...
Homozygous E2F-5 knockout embryos and mice have been generated. Although embryonic development appeared normal, newborn mice developed nonobstructive hydrocephalus, suggesting excessive cerebrospinal...
Cantor, Sharon, Drapkin, Ronny, Zhang, Fan, Lin, Yafang, Han, Juliana, Pamidi, Sushmita, ...
BACH1 is a nuclear protein that directly interacts with the highly conserved, C-terminal BRCT repeats of the tumor suppressor, BRCA1. Mutations within the BRCT repeats disrupt the interaction between...
Taubert, Stefan, Gorrini, Chiara, Frank, Scott R., Parisi, Tiziana, Fuchs, Miriam, Chan, Ho-Man, ...
E2F proteins can either activate or repress transcription. Following mitogenic stimulation, repressive E2F4-p130-histone deacetylase complexes dissociate from, while activating species (E2F1, -2, and...
Livingston, David M., Scolnick, Edward M., Parks, Wade P., Todaro, George J.
A solid phase immunoadsorbent specific for RNA-dependent DNA polymerase from murine and feline RNA tumor viruses has been prepared. The enzymes from murine and feline virus but not from avian virus...
The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway
Chan, Ho Man, Narita, Masako, Lowe, Scott W., Livingston, David M.
Adenovirus E1A-associated p400 belongs to the SWI2/SNF2 family of chromatin remodeling proteins. Here, we report that p400 is a component of the p53–p21WAF1/CIP1/sid1 pathway, regulating the p21...
Kanellopoulou, Chryssa, Muljo, Stefan A., Kung, Andrew L., Ganesan, Shridar, Drapkin, Ronny, Jenuwein, Thomas, ...
Dicer is the enzyme that cleaves double-stranded RNA (dsRNA) into 21–25-nt-long species responsible for sequence-specific RNA-induced gene silencing at the transcriptional, post-transcriptional, or...
Homeotic transformations of the axial skeleton that accompany a targeted deletion of E2f6
Storre, Jörg, Elsässer, Hans-Peter, Fuchs, Miriam, Ullmann, Diana, Livingston, David M., Gaubatz, Stefan
E2F transcription factors play an important role in regulating mammalian cell proliferation. E2F6, the most recently identified E2F family member, is a transcriptional repressor. In an effort to...
MYC recruits the TIP60 histone acetyltransferase complex to chromatin
Frank, Scott R., Parisi, Tiziana, Taubert, Stefan, Fernandez, Paula, Fuchs, Miriam, Chan, Ho-Man, ...
The transcription factor MYC binds specific DNA sites in cellular chromatin and induces the acetylation of histones H3 and H4. However, the histone acetyltransferases (HATs) that are responsible for...
Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes
Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B., Nakatani, Yoshihiro, Livingston, David M.
The BRCA1 gene product and its stoichiometric binding partner, BARD1, play a vital role in the cellular response to DNA damage. However, how they acquire specific biochemical functions after DNA...
Association of BRCA1 with the inactive X chromosome and XIST RNA.
Ganesan, Shridar, Silver, Daniel P, Drapkin, Ronny, Greenberg, Roger, Feunteun, Jean, Livingston, David M
Breast cancer, early onset 1 (BRCA1) encodes a nuclear protein that participates in breast and ovarian cancer suppression. The molecular basis for the gender and tissue specificity of the BRCA1...
Analysis of PALB2/FANCN-associated breast cancer families
Tischkowitz, Marc, Xia, Bing, Sabbaghian, Nelly, Reis-Filho, Jorge S., Hamel, Nancy, Li, Guilan, ...
No more than ≈30% of hereditary breast cancer has been accounted for by mutations in known genes. Most of these genes, such as BRCA1, BRCA2, TP53, CHEK2, ATM, and FANCJ/BRIP1, function in DNA...
p21 transcription is regulated by differential localization of histone H2A.Z
Gévry, Nicolas, Chan, Ho Man, Laflamme, Liette, Livingston, David M., Gaudreau, Luc
In yeast cells, H2A.Z regulates transcription and is globally associated within a few nucleosomes of the initiator regions of numerous promoters. H2A.Z is deposited at these loci by an ATP-dependent...
Aberrant T cell differentiation in the absence of Dicer
Muljo, Stefan A., Ansel, K. Mark, Kanellopoulou, Chryssa, Livingston, David M., Rao, Anjana, Rajewsky, Klaus
Dicer is an RNaseIII-like enzyme that is required for generating short interfering RNAs and microRNAs. The latter have been implicated in regulating cell fate determination in invertebrates and...
Parks, Wade P., Livingston, David M., Todaro, George J., Benveniste, Raoul E., Scolnick, Edward M.
A radioimmunoassay specific for a murine leukemia virus structural protein, the gs antigen, detects an antigenic reactivity in normal murine cells in culture and natural tissues. The assay was shown...
X chromosome inactivation in the absence of Dicer
Kanellopoulou, Chryssa, Muljo, Stefan A., Dimitrov, Stoil D., Chen, Xi, Colin, Christian, Plath, Kathrin, ...
Dicer is central to the RNA interference (RNAi) pathway, because it is required for processing of double-stranded RNA (dsRNA) precursors into small RNA effector molecules. In principle, any long...