Parthasarathy, Narayanan, DeShazer, David, England, Marilyn, Waag, David M.
A polysaccharide microarray platform was prepared by immobilizing Burkholderia pseudomallei and Burkholderia mallei polysaccharides. This polysaccharide array was tested with success for detecting B....
Ulrich, Rick L., Amemiya, Kei, Waag, David M., Roy, Chad J., DeShazer, David
Burkholderia mallei is an obligate mammalian pathogen that causes the zoonotic disease glanders. Two live attenuated B. mallei strains, a capsule mutant and a branched-chain amino acid auxotroph,...
Waag, David M., McCluskie, Michael J., Zhang, Ningli, Krieg, Arthur M.
Oligonucleotides containing CpG motifs were tested for protective efficacy in a mouse Burkholderia mallei aerosol challenge model. CpG 7909 protected all mice from death up to 7 weeks after...
Trevino, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...
Amemiya, Kei, Meyers, Jennifer L., Trevino, Sylvia R., Chanh, Tran C., Norris, Sarah L., Waag, David M.
We evaluated the effect of interleukin (IL)-12 on the immune response to Burkholderia mallei in BALB/c mice. Mice were vaccinated with non-viable B. mallei cells with or without IL-12. There was a...
Heine, Henry S., England, Marilyn J., Waag, David M., Byrne, W. Russell
In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to...
Nonviable Burkholderia mallei Induces a Mixed Th1- and Th2-Like Cytokine Response in BALB/c Mice
Amemiya, Kei, Bush, Gary V., DeShazer, David, Waag, David M.
Nonviable cell preparations of Burkholderia mallei, the causative agent of glanders, were evaluated as potential vaccine candidates in a BALB/c murine model. Three different B. mallei cell...
A CpG Oligonucleotide Can Protect Mice from a Low Aerosol Challenge Dose of Burkholderia mallei
Waag, David M., McCluskie, Michael J., Zhang, Ningli, Krieg, Arthur M.
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei....
Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge
Treviño, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...
Heine, Henry S., England, Marilyn J., Waag, David M., Byrne, W. Russell
In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to...
Nonviable Burkholderia mallei Induces a Mixed Th1- and Th2-Like Cytokine Response in BALB/c Mice
Amemiya, Kei, Bush, Gary V., DeShazer, David, Waag, David M.
Nonviable cell preparations of Burkholderia mallei, the causative agent of glanders, were evaluated as potential vaccine candidates in a BALB/c murine model. Three different B. mallei cell...
A CpG Oligonucleotide Can Protect Mice from a Low Aerosol Challenge Dose of Burkholderia mallei
Waag, David M., McCluskie, Michael J., Zhang, Ningli, Krieg, Arthur M.
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei....
Monoclonal Antibodies Passively Protect BALB/c Mice against Burkholderia mallei Aerosol Challenge
Treviño, Sylvia R., Permenter, Amy R., England, Marilyn J., Parthasarathy, Narayanan, Gibbs, Paul H., Waag, David M., ...
Glanders is a debilitating disease with no vaccine available. Murine monoclonal antibodies were produced against Burkholderia mallei, the etiologic agent of glanders, and were shown to be effective...
Fernandes, Paula J., Guo, Qin, Waag, David M., Donnenberg, Michael S.
Burkholderia mallei is the cause of glanders and a proven biological weapon. We identified and purified the type IV pilin protein of this organism to study its potential as a subunit vaccine. We...
Waag, David M., England, Marilyn J., Bolt, Christopher R., Williams, Jim C.
Although the phase I Coxiella burnetii cellular vaccine is completely efficacious in humans, adverse local and systemic reactions may develop if immune individuals are inadvertently vaccinated. The...
Shanks, John, Burtnick, Mary N., Brett, Paul J., Waag, David M., Spurgers, Kevin B., Ribot, Wilson J., ...
Burkholderia mallei, a category B biothreat agent, is a facultative intracellular pathogen that causes the zoonotic disease glanders. The B. mallei VirAG two-component regulatory system activates the...