Ashktorab, Hassan, Tsang, Shirley, Luke, Brian T., Sun, Zhonghe, Adams-Campbell, Lucile L., Kwagyan, John, ...
BACKGROUND: Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development. PATIENTS AND METHODS: We explored possible...
Candidate genes and cerebral palsy: a population-based study (2008)
Gibson, Catherine S., MacLennan, Alastair H., Dekker, Gustaaf A., Goldwater, Paul N., Sullivan, Thomas R., Munroe, David, ...
OBJECTIVE: The objective of this study was to examine whether selected genetic polymorphisms in the infant are associated with later-diagnosed cerebral palsy. METHODS: A population-based case-control...
Fatima, Naheed, Yi, Ming, Ajaz, Sadia, Stephens, Robert M., Stauffer, Stacey, Greenwald, Peter, ...
It is well established that celecoxib, a selective inhibitor of cyclooxygenase-2 (COX-2) and a tested chemopreventive agent, has several COX-2-independent activities. In an attempt to better...
Protein microarray on-demand: a novel protein microarray system (2008)
Chatterjee, Deb K, Sitaraman, Kalavathy, Baptista, Cassio, Hartley, James, Hill, Thomas M, Munroe, David
We describe a novel, simple and low-cost protein microarray strategy wherein the microarrays are generated by printing expression ready plasmid DNAs onto slides that can be converted into protein...
Levine, A. Joan, Wallace, Kristin, Tsang, Shirley, Haile, Robert W., Saibil, Fred, Ahnen, Dennis J., ...
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. We assessed the association between two common MTHFR variants, 677C>T and 1298A>C, and adenoma recurrence in the...
Hiroyuki Nakai, Xiaolin Wu, Sally Fuess, Theresa A. Storm, David Munroe, Eugenio Montini, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...
MC1R variants increase risk of melanomas harboring BRAF mutations (2008)
Fargnoli, Maria Concetia, Pike, Kris, Pfeiffer, Ruth M., Tsang, Shirley, Rozenblum, Ester, Munroe, David, ...
Melanocortin-1 receptor (MC1R) variants have been associated with BRAF (v-raf murine sarcoma viral oncogene homolog B1) mutations in non-CSD (chronic solar-damaged) melanomas in an Italian and an...
Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells (2007)
Reinhold, William C., Reimers, Mark A., Maunakea, Alika K., Kim, Sohyoung, Lababidi, Samir, Scherf, Uwe, ...
E-cadherin (E-cad) is a transmembrane adhesion glycoprotein, the expression of which is often reduced in invasive or metastatic tumors. To assess E-cad's distribution among different types of cancer...
Three microarray platforms: an analysis of their concordance in profiling gene expression (2005)
Petersen, David, Chandramouli, GVR, Geoghegan, Joel, Hilburn, Joanne, Paarlberg, Jonathon, Kim, Chang, ...
Abstract Background Microarrays for the analysis of gene expression are of three different types: short oligonucleotide (25–30 base), long oligonucleotide (50–80 base), and cDNA (highly variable...
Bmc Genomics, David Petersen, Gvr Ch, Joel Geoghegan, Joanne Hilburn, Jonathon Paarlberg, ...
Research article Three microarray platforms: an analysis of their concordance in profiling gene expression
MC1R, ASIP, and DNA Repair in Sporadic and Familial Melanoma in a Mediterranean Population (2005)
Landi, Maria Teresa, Kanetsky, Peter A., Tsang, Shirley, Gold, Bert, Munroe, David, Rebbeck, Timothy, ...
Background: Melanoma risk factors include fair pigmentation, multiple nevi, low DNA repair capacity, and CDKN2A or CDK4 mutations. Variants of the melanocortin-1 receptor (MC1R) gene have been...
Lsh, an epigenetic guardian of repetitive elements (2004)
Huang, Jiaqiang, Fan, Tao, Yan, Qingsheng, Zhu, Heming, Fox, Stephen, Issaq, Haleem J., ...
The genome is burdened with repetitive sequences that are generally embedded in silenced chromatin. We have previously demonstrated that Lsh (lymphoid-specific helicase) is crucial for the control of...
mRNA Poly(A) tail: a 3' Enhancer of Translational Initiation: a Thesis (1999)
Most eukaryotic mRNAs have a sequence of polyadenylic acid [poly(A)] at their 3'-termini. Although it has been almost two decades since the discovery of these poly(A) tracts, their function(s) have...
Tales of poly(A): a review (1990)
Munroe, David, Jacobson, Allan
Until recently, evidence to support a translational role for the 3'-poly(A) tract of eukaryotic mRNAs has been mostly indirect, including: a correlation between the adenylation status of individual...
mRNA poly(A) tail, a 3' enhancer of translational initiation (1990)
Munroe, David, Jacobson, Allan
To evaluate the hypothesis that the 3' poly(A) tract of mRNA plays a role in translational initiation, we constructed derivatives of pSP65 which direct the in vitro synthesis of mRNAs with different...
Thesis (Ph. D.)--University of Massachusetts Medical School, 1989.
Lsh, an epigenetic guardian of repetitive elements
Huang, Jiaqiang, Fan, Tao, Yan, Qingsheng, Zhu, Heming, Fox, Stephen, Issaq, Haleem J., ...
The genome is burdened with repetitive sequences that are generally embedded in silenced chromatin. We have previously demonstrated that Lsh (lymphoid-specific helicase) is crucial for the control of...
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
Nakai, Hiroyuki, Wu, Xiaolin, Fuess, Sally, Storm, Theresa A., Munroe, David, Montini, Eugenio, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...
Three microarray platforms: an analysis of their concordance in profiling gene expression
Petersen, David, Chandramouli, GVR, Geoghegan, Joel, Hilburn, Joanne, Paarlberg, Jonathon, Kim, Chang Hee, ...
Lsh, an epigenetic guardian of repetitive elements
Huang, Jiaqiang, Fan, Tao, Yan, Qingsheng, Zhu, Heming, Fox, Stephen, Issaq, Haleem J., ...
The genome is burdened with repetitive sequences that are generally embedded in silenced chromatin. We have previously demonstrated that Lsh (lymphoid-specific helicase) is crucial for the control of...
Large-Scale Molecular Characterization of Adeno-Associated Virus Vector Integration in Mouse Liver
Nakai, Hiroyuki, Wu, Xiaolin, Fuess, Sally, Storm, Theresa A., Munroe, David, Montini, Eugenio, ...
Recombinant adeno-associated virus (rAAV) vector holds promise for gene therapy. Despite a low frequency of chromosomal integration of vector genomes, recent studies have raised concerns about the...