Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (2009)
Yu, Yong, Chu, Po-Yin, Bowser, David N., Keating, Damien J., Dubach, Daphne, Harper, Ian, ...
Mice deficient for the chromosome 21 ortholog Itsn1 exhibit vesicle-trafficking abnormalities (2008)
Yu, Yong, Chu, Po-Yin, Bowser, David N., Keating, Damien J., Dubach, Daphne, Harper, Ian, ...
Enlarged early endosomes in the neurons of young Down syndrome (DS) and pre-Alzheimer’s disease (AD) brains suggest that a disturbance in endocytosis is one of the earliest hallmarks of AD...
Bowser, David N., Wagner, David A., Czajkowski, Cynthia, Cromer, Brett A., Parker, Michael W., Wallace, Robyn H., ...
The γ-aminobutyric acid type A (GABAA) receptor mediates fast inhibitory synaptic transmission in the CNS. Dysfunction of the GABAA receptor would be expected to cause neuronal hyperexcitability, a...
Bowser, David N., Wagner, David A., Czajkowski, Cynthia, Cromer, Brett A., Parker, Michael W., Wallace, Robyn H., ...
The γ-aminobutyric acid type A (GABAA) receptor mediates fast inhibitory synaptic transmission in the CNS. Dysfunction of the GABAA receptor would be expected to cause neuronal hyperexcitability, a...
Harkin, Louise A., Bowser, David N., Dibbens, Leanne M., Singh, Rita, Phillips, Fiona, Wallace, Robyn H., ...
Recent findings from studies of two families have shown that mutations in the GABAA-receptor γ2 subunit are associated with generalized epilepsies and febrile seizures. Here we describe a family...
Bowser, David N., Khakh, Baljit S.
Transmitters such as glutamate and ATP are released from brain astrocytes. Several pathways for their release have been proposed, including exocytosis. In the present study we sought to measure...
Vesicular ATP Is the Predominant Cause of Intercellular Calcium Waves in Astrocytes
Bowser, David N., Khakh, Baljit S.
Brain astrocytes signal to each other and neurons. They use changes in their intracellular calcium levels to trigger release of transmitters into the extracellular space. These can then activate...