Koga, Tomoyuki, Morita, Akio, Maruyama, Keisuke, Tanaka, Minoru, Ino, Yasushi, Shibahara, Junji, ...
Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic neoplasm of the brain. Some PXAs are accompanied by anaplastic features and are difficult to manage because of frequent recurrences that lead...
Malignant astrocytic glioma: genetics, biology, and paths to treatment (2007)
Furnari, Frank B., Fenton, Tim, Bachoo, Robert M., Mukasa, Akitake, Stommel, Jayne M., Stegh, Alexander, ...
Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion...
Survey of treatment recommendations for anaplastic oligodendroglioma (2007)
Abrey, Lauren E., Louis, David N., Paleologos, Nina, Lassman, Andrew B., Raizer, Jeffrey J., Mason, Warren, ...
Anaplastic oligodendroglioma is a malignant brain tumor uniquely sensitive to treatment with both chemotherapy and radiotherapy. There are few prospective clinical trials for newly diagnosed patients...
Patterns of somatic mutation in human cancer genomes (2007)
Greenman, Christopher, Stephens, Philip, Smith, Raffaella, Dalgliesh, Gillian L., Hunter, Christopher, Bignell, Graham, ...
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for...
Patterns of somatic mutation in human cancer genomes (2007)
Greenman, Christopher, Stephens, Philip, Smith, Raffaella, Dalgliesh, Gillian L., Hunter, Christopher, Bignell, Graham, ...
Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose that systematic resequencing of cancer genomes for...
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma (2007)
Stegh, Alexander H., Kim, Hyunggee, Bachoo, Robert M., Forloney, Kristin L., Zhang, Jean, Schulze, Harald, ...
Glioblastoma (GBM) is an astrocytic brain tumor characterized by an aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification and functional...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca A.
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based Comparative Genomic Hybridization (aCGH) is a recent development that seeks to identify...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca A.
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based comparative genomic hybridization (aCGH) is a recent development that seeks to identify...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based Comparative Genomic Hybridization (aCGH) is a recent development that seeks to identify...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based Comparative Genomic Hybridization (aCGH) is a recent development that seeks to identify...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based Comparative Genomic Hybridization (aCGH) is a recent development that seeks to identify...
Engler, David A., Mohapatra, Gayatry, Louis, David N., Betensky, Rebecca
DNA sequence copy number has been shown to be associated with cancer development and progression. Array-based Comparative Genomic Hybridization (aCGH) is a recent development that seeks to identify...
Voloschin, Alfredo D., Louis, David N., Cosgrove, Garth R., Batchelor, Tracy T.
A 38-year-old woman presented with an infiltrative tumor of the right frontal lobe and genu of the corpus callosum that was deemed only partially resectable. A stereotactic biopsy was performed,...
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration (2004)
Sloan, Kevin E, Eustace, Brenda K, Stewart, Jean K, Zehetmeier, Carol, Torella, Claudia, Simeone, Marina, ...
Abstract Background Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of...
Analysis of a molecular genetic neuro-oncology study with partially biased selection (2003)
Betensky, Rebecca A., Louis, David N., Cairncross, J. Gregory
Oligodendrogliomas are a common variant of malignant brain tumors, and are unique for their relative sensitivity to chemotherapy and better prognosis. For these reasons, the identification of an...
Dai, Chengkai, Celestino, Joseph C., Okada, Yoshifumi, Louis, David N., Fuller, Greory N., Holland, Eric C.
Malignant glioma: genetics and biology of a grave matter (2001)
Maher, Elizabeth A., Furnari, Frank B., Bachoo, Robert M., Rowitch, David H., Louis, David N., Cavenee, Webster K., ...
Ueki, Keisuke, Rubio, Mari-Paz, Ramesh, Vijaya, Correa, Katia M., Rutter, Joni L., Deimling, Andreas Von, ...
Human astrocytomas frequently have allelic losses of chromosome 9p, suggesting the presence of a 9p astrocytoma tumor suppressor gene. The MTS1 (or CDKN2) gene on chromosome 9p encodes a cell-cycle...
Nucleolar organizer regions in optic gliomas (1993)
Burnstine, Michael A., Levin, Leonard A., Louis, David N., Kupsky, William J., Doepner, Dietrich, ...
The biological nature of optic gliomas is controversial, with some considering them benign hamartomatous lesions, and others believing them to be true neoplasms. We evaluated the use of colloid...
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
Lu, Q. Richard, Park, John K., Noll, Elizabeth, Chan, Jennifer A., Alberta, John, Yuk, Dongin, ...
The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers...
Dickson, Mark A., Hahn, William C., Ino, Yasushi, Ronfard, Vincent, Wu, Jenny Y., Weinberg, Robert A., ...
Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in...
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
Ikeda, Keiro, Wakimoto, Hiroaki, Ichikawa, Tomotsugu, Jhung, Sarah, Hochberg, Fred H., Louis, David N., ...
Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here...
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
Sloan, Kevin E, Eustace, Brenda K, Stewart, Jean K, Zehetmeier, Carol, Torella, Claudia, Simeone, Marina, ...
Niida, Yo, Stemmer-Rachamimov, Anat O., Logrip, Marian, Tapon, Dagmar, Perez, Ronald, Kwiatkowski, David J., ...
Tuberous sclerosis complex (TSC), an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. Concordant with...
Dai, Chengkai, Celestino, Joseph C., Okada, Yoshifumi, Louis, David N., Fuller, Greory N., Holland, Eric C.
We present evidence that some low-grade oligodendrogliomas may be comprised of proliferating glial progenitor cells that are blocked in their ability to differentiate, whereas malignant gliomas have...
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
Lu, Q. Richard, Park, John K., Noll, Elizabeth, Chan, Jennifer A., Alberta, John, Yuk, Dongin, ...
The most common primary tumors of the human brain are thought to be of glial cell origin. However, glial cell neoplasms cannot be fully classified by cellular morphology or with conventional markers...
Dickson, Mark A., Hahn, William C., Ino, Yasushi, Ronfard, Vincent, Wu, Jenny Y., Weinberg, Robert A., ...
Normal human cells exhibit a limited replicative life span in culture, eventually arresting growth by a process termed senescence. Progressive telomere shortening appears to trigger senescence in...
Lu, Xiangdong, Magrane, Gregg, Yin, Chaoying, Louis, David N., Gray, Joe, Van Dyke, Terry
We examined the selective pressure for, and the impact of, p53 inactivation during epithelial tumor evolution in a transgenic brain tumor model. In TgT121 mice, cell-specific inactivation of the pRb...
Ikeda, Keiro, Wakimoto, Hiroaki, Ichikawa, Tomotsugu, Jhung, Sarah, Hochberg, Fred H., Louis, David N., ...
Intravascular routes of administration can provide a means to target gene- and virus-based therapies to multiple tumor foci located within an organ, such as the brain. However, we demonstrate here...
Dai, Chengkai, Celestino, Joseph C., Okada, Yoshifumi, Louis, David N., Fuller, Greory N., Holland, Eric C.
We present evidence that some low-grade oligodendrogliomas may be comprised of proliferating glial progenitor cells that are blocked in their ability to differentiate, whereas malignant gliomas have...
CD155/PVR plays a key role in cell motility during tumor cell invasion and migration
Sloan, Kevin E, Eustace, Brenda K, Stewart, Jean K, Zehetmeier, Carol, Torella, Claudia, Simeone, Marina, ...
Niida, Yo, Stemmer-Rachamimov, Anat O., Logrip, Marian, Tapon, Dagmar, Perez, Ronald, Kwiatkowski, David J., ...
Tuberous sclerosis complex (TSC), an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. Concordant with...
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
Fulci, Giulia, Breymann, Laura, Gianni, Davide, Kurozomi, Kazuhiko, Rhee, Sarah S., Yu, Jianhua, ...
Clinical trials are testing oncolytic viruses (OVs) as therapies for cancer. We have shown that animals that have brain tumors and are treated with a herpes simplex virus (HSV)-derived OV live...
Riemenschneider, Markus J., Mueller, Wolf, Betensky, Rebecca A., Mohapatra, Gayatry, Louis, David N.
Deregulated integrin signaling is common in cancers, including glioblastoma. Integrin binding and growth factor receptor signaling activate focal adhesion kinase (FAK) and subsequently up-regulate...
The Role of the Cyclin D1-Dependent Kinases in ErbB2-Mediated Breast Cancer
Yang, Chuanwei, Ionescu-Tiba, Viviana, Burns, Karen, Gadd, Michelle, Zukerberg, Lawrence, Louis, David N., ...
Intact cyclin D1 functions are essential for transformation by erbB2 in tissue culture and murine models. Because cyclin D1 may alter cell proliferation through a variety of mechanisms, we used...
Plummer, Nicholas W., Gallione, Carol J., Srinivasan, Sudha, Zawistowski, Jon S., Louis, David N., Marchuk, Douglas A.
Cerebral cavernous malformations (CCM) consist of clusters of abnormally dilated blood vessels. Hemorrhaging of these lesions can cause seizures and lethal stroke. Three loci are associated with...
CDKN2A Gene Deletions and Loss of p16 Expression Occur in Osteosarcomas That Lack RB Alterations
Nielsen, Gunnlaugur P., Burns, Karen L., Rosenberg, Andrew E., Louis, David N.
Osteosarcomas often suffer mutations of the RB (retinoblastoma) gene, with resultant inactivation of the pRb protein. pRb is one component in a cell-cycle control pathway that includes the p16...
Voloschin, Alfredo D., Louis, David N., Cosgrove, Garth R., Batchelor, Tracy T.
A 38-year-old woman presented with an infiltrative tumor of the right frontal lobe and genu of the corpus callosum that was deemed only partially resectable. A stereotactic biopsy was performed,...
Nielsen, Gunnlaugur P., Stemmer-Rachamimov, Anat O., Ino, Yasushi, Møller, Michael B., Rosenberg, Andrew E., Louis, David N.
Patients with neurofibromatosis 1 (NF1) are predisposed to develop multiple neurofibromas (NFs) and are at risk for transformation of NFs to malignant peripheral nerve sheath tumors (MPNSTs). Little...
Stemmer-Rachamimov, Anat O., Wiederhold, Thorsten, Nielsen, G. Petur, James, Marianne, Pinney-Michalowski, Denise, Roy, Jennifer E., ...
NHE-RF, a regulatory cofactor for NHE (Na+-H+ exchanger) type 3, interacts with ion transporters and receptors through its PDZ domains and with the MERM proteins (merlin, ezrin, radixin and moesin)...
Sasaki, Hikaru, Zlatescu, Magdalena C., Betensky, Rebecca A., Ino, Yasushi, Cairncross, J. Gregory, Louis, David N.
Allelic loss of 10q is a common genetic event in malignant gliomas, with three 10q tumor suppressor genes, ERCC6, PTEN, and DMBT1, putatively implicated in the most common type of malignant glioma,...
Mueller, Wolf, Hartmann, Christian, Hoffmann, Annegret, Lanksch, Wolfgang, Kiwit, Jürgen, Tonn, Jörg, ...
Oligoastrocytomas are heterogeneous tumors that have molecular features that overlap with either oligodendrogliomas or astrocytomas. Differences in the frequency of chromosomal losses of 1p and 19q...
Wong, Albert J., Padarathsingh, Martin, Louis, David N., Rempel, Sandra, Ladisch, Stephan, Gladson, Candece
Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma
Stegh, Alexander H., Kim, Hyunggee, Bachoo, Robert M., Forloney, Kristin L., Zhang, Jean, Schulze, Harald, ...
Glioblastoma (GBM) is an astrocytic brain tumor characterized by an aggressive clinical course and intense resistance to all therapeutic modalities. Here, we report the identification and functional...
Betensky, Rebecca A., Nutt, Catherine L., Batchelor, Tracy T., Louis, David N.
In recent years there have been a number of microarray expression studies in which different types of tumors were classified by identifying a panel of differentially expressed genes....
Mohapatra, Gayatry, Betensky, Rebecca A., Miller, Ezra R., Carey, Bjorn, Gaumont, Leah D., Engler, David A., ...
Array-based comparative genomic hybridization (aCGH) is a powerful, high-throughput tool for whole genome analysis. Until recently, aCGH could only be reproducibly performed on frozen tissue samples...
Mutational Analysis of Patients with Neurofibromatosis 2
MacCollin, Mia, Ramesh, Vijaya, Jacoby, Lee B., Louis, David N., Rubio, Mari-Paz, Pulaski, Karen, ...
Neurofibromatosis 2 (NF2) is a genetic disorder characterized by the development of multiple nervous-system tumors in young adulthood. The NF2 gene has recently been isolated and found to encode a...
The 2007 WHO Classification of Tumours of the Central Nervous System
Louis, David N., Ohgaki, Hiroko, Wiestler, Otmar D., Cavenee, Webster K., Burger, Peter C., Jouvet, Anne, ...
The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma,...
Survey of treatment recommendations for anaplastic oligodendroglioma
Abrey, Lauren E., Louis, David N., Paleologos, Nina, Lassman, Andrew B., Raizer, Jeffrey J., Mason, Warren, ...
Anaplastic oligodendroglioma is a malignant brain tumor uniquely sensitive to treatment with both chemotherapy and radiotherapy. There are few prospective clinical trials for newly diagnosed patients...
Stegh, Alexander H., Kesari, Santosh, Mahoney, John E., Jenq, Harry T., Forloney, Kristin L., Protopopov, Alexei, ...
Glioblastoma multiforme (GBM) is a highly aggressive brain cancer that is characterized by the paradoxical features of intense apoptosis resistance yet a marked propensity to undergo necrosis....
“MGMT for pt mgmt”: Is Methylguanine-DNA Methyltransferase Testing Ready for Patient Management?
Iafrate, A. John, Louis, David N.
This Commentary reports on a robust quantitative assay for the interpretation of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation assays that should facilitate the comparison and...