Aurrecoechea, Cristina, Brestelli, John, Brunk, Brian P., Carlton, Jane M., Dommer, Jennifer, Fischer, Steve, ...
GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the...
PlasmoDB: a functional genomic database for malaria parasites (2009)
Aurrecoechea, Cristina, Brestelli, John, Brunk, Brian P., Dommer, Jennifer, Fischer, Steve, Gajria, Bindu, ...
PlasmoDB (http://PlasmoDB.org) is a functional genomic database for Plasmodium spp. that provides a resource for data analysis and visualization in a gene-by-gene or genome-wide scale. PlasmoDB...
Reranking candidate gene models with cross-species comparison for improved gene prediction (2008)
Liu, Qian, Crammer, Koby, Pereira, Fernando CN, Roos, David S
Abstract Background Most gene finders score candidate gene models with state-based methods, typically HMMs, by combining local properties (coding potential, splice donor and acceptor patterns, etc)....
Reranking candidate gene models with cross-species comparison for improved gene prediction (2008)
Liu, Qian, Crammer, Koby, Pereira, Fernando CN, Roos, David S
Background: Most gene finders score candidate gene models with state-based methods, typically HMMs, by combining local properties (coding potential, splice donor and acceptor patterns, etc)....
Aurrecoechea, Cristina, Brestelli, John, Brunk, Brian P., Carlton, Jane M., Dommer, Jennifer, Fischer, Steve, ...
© 2008 The Authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. The definitive version was published in Nucleic Acids...
Xia, Dong, Sanderson, Sanya J, Jones, Andrew R, Prieto, Judith H, Yates, John R, Bromley, Elizabeth, ...
Abstract Background Although the genomes of many of the most important human and animal pathogens have now been sequenced, our understanding of the actual proteins expressed by these genomes and how...
ToxoDB: an integrated Toxoplasma gondii database resource (2008)
Gajria, Bindu, Bahl, Amit, Brestelli, John, Dommer, Jennifer, Fischer, Steve, Gao, Xin, ...
ToxoDB (http://ToxoDB.org) is a genome and functional genomic database for the protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T. gondii ME49 strain, as well...
BMC Bioinformatics BioMed Central Methodology article (2008)
Qian Liu, Koby Crammer, O Cn Pereira, David S Roos
Reranking candidate gene models with cross-species comparison for improved gene prediction
No abstract available.
Creating a honey bee consensus gene set (2007)
Elsik, Christine G, Mackey, Aaron J, Reese, Justin T, Milshina, Natalia V, Roos, David S, Weinstock, George M
Abstract Background We wished to produce a single reference gene set for honey bee ( Apis mellifera ). Our motivation was twofold. First, we wished to obtain an improved set of gene models with...
ApiDB: integrated resources for the apicomplexan bioinformatics resource center (2007)
Cristina Aurrecoechea, Mark Heiges, Haiming Wang, Zhiming Wang, Steve Fischer, John Miller, ...
resource center
ApiDB: integrated resources for the apicomplexan bioinformatics resource center (2007)
Aurrecoechea, Cristina, Heiges, Mark, Wang, Haiming, Wang, Zhiming, Fischer, Steve, Rhodes, Philippa, ...
ApiDB (http://ApiDB.org) represents a unified entry point for the NIH-funded Apicomplexan Bioinformatics Resource Center (BRC) that integrates numerous database resources and multiple data types. The...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii (2006)
Ke Hu, Jeff Johnson, Laurence Florens, Martin Fraunholz, Sapna Suravajjala, Camille DiLullo, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups (2006)
Mackey, Aaron J, Stoeckert, Christian J, Roos, David S
The OrthoMCL database (http://orthomcl.cbil.upenn.edu) houses ortholog group predictions for 55 species, including 16 bacterial and 4 archaeal genomes representing phylogenetically diverse lineages,...
falciparum antigens by antigenic analysis of genomic and proteomic (2006)
Z. Bozdech, M. Llinas, B. L. Pulliam, E. D. Wong, J. Zhu, Z. Bozdech, ...
plasmodium
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii (2006)
Khan, Asis, Böhme, Ulrike, Kelly, Krystyna A., Adlem, Ellen, Brooks, Karen, Simmonds, Mark, ...
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has...
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii (2006)
Khan, Asis, Böhme, Ulrike, Kelly, Krystyna A., Adlem, Ellen, Brooks, Karen, Simmonds, Mark, ...
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has...
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups (2006)
Chen, Feng, Mackey, Aaron J., Stoeckert, Christian J., Roos, David S.
The OrthoMCL database (http://orthomcl.cbil.upenn.edu) houses ortholog group predictions for 55 species, including 16 bacterial and 4 archaeal genomes representing phylogenetically diverse lineages,...
The transcriptome of Toxoplasma gondii (2005)
Radke, Jay R, Behnke, Michael S, Mackey, Aaron J, Radke, Josh B, Roos, David S, White, Michael W
Abstract Background Toxoplasma gondii gives rise to toxoplasmosis, among the most prevalent parasitic diseases of animals and man. Transformation of the tachzyoite stage into the latent...
Khan, Asis, Taylor, Sonya, Su, Chunlei, Mackey, Aaron J., Boyle, Jon, Cole, Robert, ...
Toxoplasma gondii is a highly successful protozoan parasite in the phylum Apicomplexa, which contains numerous animal and human pathogens. T.gondii is amenable to cellular, biochemical, molecular and...
Omar S. Harb, Bithi Chatterjee, Martin J. Fraunholz, Michael J. Crawford, Manami Nishi, David S. Roos
Most species of the protozoan phylum Apicomplexa harbor an endosymbiotic organelle—the apicoplast— acquired when an ancestral parasite engulfed a eukaryotic plastid-containing alga. Several...
ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites (2004)
Li Li, Jonathan Crabtree, Steve Fischer, Deborah Pinney, Christian J. Stoeckert, L. David Sibley, ...
ApiEST-DB
ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites (2004)
Li, Li, Crabtree, Jonathan, Fischer, Steve, Pinney, Deborah, Stoeckert, Christian J., Sibley, L. David, ...
ApiEST‐DB (http://www.cbil.upenn.edu/paradbs‐servlet/) provides integrated access to publicly available EST data from protozoan parasites in the phylum Apicomplexa. The database currently...
ToxoDB: accessing the Toxoplasma gondii genome (2003)
Jessica C. Kissinger, Bindu Gajria, Li Li, Ian T. Paulsen, David S. Roos
ToxoDB
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes (2003)
Li, Li, Stoeckert, Christian J., Roos, David S.
The identification of orthologous groups is useful for genome annotation, studies on gene/protein evolution, comparative genomics, and the identification of taxonomically restricted sequences....
Bahl, Amit, Brunk, Brian, Crabtree, Jonathan, Fraunholz, Martin J., Gajria, Bindu, Grant, Gregory R., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates the recently completed P. falciparum genome sequence and...
ToxoDB: accessing the Toxoplasma gondii genome (2003)
Kissinger, Jessica C., Gajria, Bindu, Li, Li, Paulsen, Ian T., Roos, David S.
ToxoDB (http://ToxoDB.org) provides a genome resource for the protozoan parasite Toxoplasma gondii. Several sequencing projects devoted to T. gondii have been completed or are in progress: an EST...
Li, Li, Brunk, Brian P., Kissinger, Jessica C., Pape, Deana, Tang, Keliang, Cole, Robert H., ...
Large-scale EST sequencing projects for several important parasites within the phylum Apicomplexa were undertaken for the purpose of gene discovery. Included were several parasites of medical...
Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and...
Fast, Naomi M., Kissinger, Jessica C., Roos, David S., Keeling, Patrick J.
The phylum Apicomplexa encompasses a large number of intracellular protozoan parasites, including the causative agents of malaria (Plasmodium), toxoplasmosis (Toxoplasma), and many other human and...
Ajioka, James W., Boothroyd, John C., Brunk, Brian P., Hehl, Adrian, Hillier, Ledeana, Manger, Ian D., ...
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
Waller, Ross F., Keeling, Patrick J., Donald, Robert G. K., Striepen, Boris, Handman, Emanuela, Lang-Unnasch, Naomi, ...
A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but the complete...
Daughter Cell Assembly in the Protozoan Parasite Toxoplasma gondii
Hu, Ke, Mann, Tara, Striepen, Boris, Beckers, Con J. M., Roos, David S., Murray, John M.
The phylum Apicomplexa includes thousands of species of obligate intracellular parasites, many of which are significant human and/or animal pathogens. Parasites in this phylum replicate by assembling...
Reynolds, Mary G., Oh, Jung, Roos, David S.
Pyrimethamine is a potent inhibitor of dihydrofolate reductase and is widely used in the treatment of opportunistic infections caused by the protozoan parasite Toxoplasma gondii. In order to assess...
Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and annotation...
Swedlow, Jason R., Hu, Ke, Andrews, Paul D., Roos, David S., Murray, John M.
Toxoplasma gondii is an intracellular parasite that proliferates within most nucleated cells, an important human pathogen, and a model for the study of human and veterinary parasitic infections. We...
A plastid segregation defect in the protozoan parasite Toxoplasma gondii
He, Cynthia Y., Shaw, Michael K., Pletcher, Charles H., Striepen, Boris, Tilney, Lewis G., Roos, David S.
Apicomplexan parasites—including the causative agents of malaria (Plasmodium sp.) and toxoplasmosis (Toxoplasma gondii)—harbor a secondary endosymbiotic plastid, acquired by lateral genetic...
ToxoDB: accessing the Toxoplasma gondii genome
Kissinger, Jessica C., Gajria, Bindu, Li, Li, Paulsen, Ian T., Roos, David S.
ToxoDB (http://ToxoDB.org) provides a genome resource for the protozoan parasite Toxoplasma gondii. Several sequencing projects devoted to T. gondii have been completed or are in progress: an EST...
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
Bahl, Amit, Brunk, Brian, Crabtree, Jonathan, Fraunholz, Martin J., Gajria, Bindu, Grant, Gregory R., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates the recently completed P. falciparum genome sequence and...
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
Baldi, Deborah L., Andrews, Katherine T., Waller, Ross F., Roos, David S., Howard, Randall F., Crabb, Brendan S., ...
Rhoptry associated protein 1 (RAP1) and 2 (RAP2), together with a poorly described third protein RAP3, form the low molecular weight complex within the rhoptries of Plasmodium falciparum. These...
ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites
Li, Li, Crabtree, Jonathan, Fischer, Steve, Pinney, Deborah, Stoeckert, Christian J., Sibley, L. David, ...
ApiEST-DB (http://www.cbil.upenn.edu/paradbs-servlet/) provides integrated access to publicly available EST data from protozoan parasites in the phylum Apicomplexa. The database currently...
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, Li, Stoeckert, Christian J., Roos, David S.
The identification of orthologous groups is useful for genome annotation, studies on gene/protein evolution, comparative genomics, and the identification of taxonomically restricted sequences....
Harb, Omar S., Chatterjee, Bithi, Fraunholz, Martin J., Crawford, Michael J., Nishi, Manami, Roos, David S.
Most species of the protozoan phylum Apicomplexa harbor an endosymbiotic organelle—the apicoplast—acquired when an ancestral parasite engulfed a eukaryotic plastid-containing alga. Several...
Li, Li, Brunk, Brian P., Kissinger, Jessica C., Pape, Deana, Tang, Keliang, Cole, Robert H., ...
Large-scale EST sequencing projects for several important parasites within the phylum Apicomplexa were undertaken for the purpose of gene discovery. Included were several parasites of medical...
Dynamics of Toxoplasma gondii Differentiation†
Dzierszinski, Florence, Nishi, Manami, Ouko, Lillian, Roos, David S.
Parasite differentiation is commonly associated with transitions between complex life cycle stages and with long-term persistence in the host, and it is therefore critical for pathogenesis. In the...
Khan, Asis, Taylor, Sonya, Su, Chunlei, Mackey, Aaron J., Boyle, Jon, Cole, Robert, ...
Toxoplasma gondii is a highly successful protozoan parasite in the phylum Apicomplexa, which contains numerous animal and human pathogens. T.gondii is amenable to cellular, biochemical, molecular and...
The transcriptome of Toxoplasma gondii
Radke, Jay R, Behnke, Michael S, Mackey, Aaron J, Radke, Josh B, Roos, David S, White, Michael W
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups
Chen, Feng, Mackey, Aaron J., Stoeckert, Christian J., Roos, David S.
The OrthoMCL database () houses ortholog group predictions for 55 species, including 16 bacterial and 4 archaeal genomes representing phylogenetically diverse lineages, and most currently available...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
Waller, Ross F., Keeling, Patrick J., Donald, Robert G. K., Striepen, Boris, Handman, Emanuela, Lang-Unnasch, Naomi, ...
A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but the complete...
Daughter Cell Assembly in the Protozoan Parasite Toxoplasma gondii
Hu, Ke, Mann, Tara, Striepen, Boris, Beckers, Con J. M., Roos, David S., Murray, John M.
The phylum Apicomplexa includes thousands of species of obligate intracellular parasites, many of which are significant human and/or animal pathogens. Parasites in this phylum replicate by assembling...
Reynolds, Mary G., Oh, Jung, Roos, David S.
Pyrimethamine is a potent inhibitor of dihydrofolate reductase and is widely used in the treatment of opportunistic infections caused by the protozoan parasite Toxoplasma gondii. In order to assess...
Bahl, Amit, Brunk, Brian, Coppel, Ross L., Crabtree, Jonathan, Diskin, Sharon J., Fraunholz, Martin J., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates finished and draft genome sequence data and annotation...
Swedlow, Jason R., Hu, Ke, Andrews, Paul D., Roos, David S., Murray, John M.
Toxoplasma gondii is an intracellular parasite that proliferates within most nucleated cells, an important human pathogen, and a model for the study of human and veterinary parasitic infections. We...
A plastid segregation defect in the protozoan parasite Toxoplasma gondii
He, Cynthia Y., Shaw, Michael K., Pletcher, Charles H., Striepen, Boris, Tilney, Lewis G., Roos, David S.
Apicomplexan parasites—including the causative agents of malaria (Plasmodium sp.) and toxoplasmosis (Toxoplasma gondii)—harbor a secondary endosymbiotic plastid, acquired by lateral genetic...
ToxoDB: accessing the Toxoplasma gondii genome
Kissinger, Jessica C., Gajria, Bindu, Li, Li, Paulsen, Ian T., Roos, David S.
ToxoDB (http://ToxoDB.org) provides a genome resource for the protozoan parasite Toxoplasma gondii. Several sequencing projects devoted to T. gondii have been completed or are in progress: an EST...
PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data
Bahl, Amit, Brunk, Brian, Crabtree, Jonathan, Fraunholz, Martin J., Gajria, Bindu, Grant, Gregory R., ...
PlasmoDB (http://PlasmoDB.org) is the official database of the Plasmodium falciparum genome sequencing consortium. This resource incorporates the recently completed P. falciparum genome sequence and...
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum
Baldi, Deborah L., Andrews, Katherine T., Waller, Ross F., Roos, David S., Howard, Randall F., Crabb, Brendan S., ...
Rhoptry associated protein 1 (RAP1) and 2 (RAP2), together with a poorly described third protein RAP3, form the low molecular weight complex within the rhoptries of Plasmodium falciparum. These...
ApiEST-DB: analyzing clustered EST data of the apicomplexan parasites
Li, Li, Crabtree, Jonathan, Fischer, Steve, Pinney, Deborah, Stoeckert, Christian J., Sibley, L. David, ...
ApiEST-DB (http://www.cbil.upenn.edu/paradbs-servlet/) provides integrated access to publicly available EST data from protozoan parasites in the phylum Apicomplexa. The database currently...
OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes
Li, Li, Stoeckert, Christian J., Roos, David S.
The identification of orthologous groups is useful for genome annotation, studies on gene/protein evolution, comparative genomics, and the identification of taxonomically restricted sequences....
Harb, Omar S., Chatterjee, Bithi, Fraunholz, Martin J., Crawford, Michael J., Nishi, Manami, Roos, David S.
Most species of the protozoan phylum Apicomplexa harbor an endosymbiotic organelle—the apicoplast—acquired when an ancestral parasite engulfed a eukaryotic plastid-containing alga. Several...
Li, Li, Brunk, Brian P., Kissinger, Jessica C., Pape, Deana, Tang, Keliang, Cole, Robert H., ...
Large-scale EST sequencing projects for several important parasites within the phylum Apicomplexa were undertaken for the purpose of gene discovery. Included were several parasites of medical...
Dynamics of Toxoplasma gondii Differentiation†
Dzierszinski, Florence, Nishi, Manami, Ouko, Lillian, Roos, David S.
Parasite differentiation is commonly associated with transitions between complex life cycle stages and with long-term persistence in the host, and it is therefore critical for pathogenesis. In the...
Khan, Asis, Taylor, Sonya, Su, Chunlei, Mackey, Aaron J., Boyle, Jon, Cole, Robert, ...
Toxoplasma gondii is a highly successful protozoan parasite in the phylum Apicomplexa, which contains numerous animal and human pathogens. T.gondii is amenable to cellular, biochemical, molecular and...
The transcriptome of Toxoplasma gondii
Radke, Jay R, Behnke, Michael S, Mackey, Aaron J, Radke, Josh B, Roos, David S, White, Michael W
OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups
Chen, Feng, Mackey, Aaron J., Stoeckert, Christian J., Roos, David S.
The OrthoMCL database () houses ortholog group predictions for 55 species, including 16 bacterial and 4 archaeal genomes representing phylogenetically diverse lineages, and most currently available...
Cytoskeletal Components of an Invasion Machine—The Apical Complex of Toxoplasma gondii
Hu, Ke, Johnson, Jeff, Florens, Laurence, Fraunholz, Martin, Suravajjala, Sapna, DiLullo, Camille, ...
The apical complex of Toxoplasma gondii is widely believed to serve essential functions in both invasion of its host cells (including human cells), and in replication of the parasite. The...
Boyle, Jon P., Rajasekar, Badri, Saeij, Jeroen P. J., Ajioka, James W., Berriman, Matthew, Paulsen, Ian, ...
Toxoplasma gondii, an obligate intracellular protozoan of the phylum Apicomplexa, is estimated to infect over a billion people worldwide as well as a great many other mammalian and avian hosts....
ApiDB: integrated resources for the apicomplexan bioinformatics resource center
Aurrecoechea, Cristina, Heiges, Mark, Wang, Haiming, Wang, Zhiming, Fischer, Steve, Rhodes, Philippa, ...
ApiDB () represents a unified entry point for the NIH-funded Apicomplexan Bioinformatics Resource Center (BRC) that integrates numerous database resources and multiple data types. The phylum...
Common inheritance of chromosome Ia associated with clonal expansion of Toxoplasma gondii
Khan, Asis, Böhme, Ulrike, Kelly, Krystyna A., Adlem, Ellen, Brooks, Karen, Simmonds, Mark, ...
Toxoplasma gondii is a globally distributed protozoan parasite that can infect virtually all warm-blooded animals and humans. Despite the existence of a sexual phase in the life cycle, T. gondii has...
Mining the Plasmodium genome database to define organellar function: what does the apicoplast do?
Roos, David S, Crawford, Michael J, Donald, Robert G K, Fraunholz, Martin, Harb, Omar S, He, Cynthia Y, ...
Apicomplexan species constitute a diverse group of parasitic protozoa, which are responsible for a wide range of diseases in many organisms. Despite differences in the diseases they cause, these...
Creating a honey bee consensus gene set
Elsik, Christine G, Mackey, Aaron J, Reese, Justin T, Milshina, Natalia V, Roos, David S, Weinstock, George M
A high-quality consensus gene set for the honey bee (Apis mellifera) created using a new algorithm (GLEAN) is described.
Assessing Performance of Orthology Detection Strategies Applied to Eukaryotic Genomes
Chen, Feng, Mackey, Aaron J., Vermunt, Jeroen K., Roos, David S.
Orthology detection is critically important for accurate functional annotation, and has been widely used to facilitate studies on comparative and evolutionary genomics. Although various methods are...
Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast
Crawford, Michael J, Thomsen-Zieger, Nadine, Ray, Manisha, Schachtner, Joachim, Roos, David S, Seeber, Frank
In contrast to other eukaryotes, which manufacture lipoic acid, an essential cofactor for several vital dehydrogenase complexes, within the mitochondrion, we show that the plastid (apicoplast) of the...
ToxoDB: an integrated Toxoplasma gondii database resource
Gajria, Bindu, Bahl, Amit, Brestelli, John, Dommer, Jennifer, Fischer, Steve, Gao, Xin, ...
ToxoDB (http://ToxoDB.org) is a genome and functional genomic database for the protozoan parasite Toxoplasma gondii. It incorporates the sequence and annotation of the T. gondii ME49 strain, as well...
Dzierszinski, Florence, Pepper, Marion, Stumhofer, Jason S., LaRosa, David F., Wilson, Emma H., Turka, Laurence A., ...
Challenge with the intracellular protozoan parasite Toxoplasma gondii induces a potent CD8+ T-cell response that is required for resistance to infection, but many questions remain about the factors...
The Plastid of Toxoplasma gondii Is Divided by Association with the Centrosomes
Striepen, Boris, Crawford, Michael J., Shaw, Michael K., Tilney, Lewis G., Seeber, Frank, Roos, David S.
Apicomplexan parasites harbor a single nonphotosynthetic plastid, the apicoplast, which is essential for parasite survival. Exploiting Toxoplasma gondii as an accessible system for cell biological...
A novel polymer of tubulin forms the conoid of Toxoplasma gondii
Hu, Ke, Roos, David S., Murray, John M.
Toxoplasma gondii is an obligatory intracellular parasite, an important human pathogen, and a convenient laboratory model for many other human and veterinary pathogens in the phylum Apicomplexa, such...
Secretory traffic in the eukaryotic parasite Toxoplasma gondii: less is more
Joiner, Keith A., Roos, David S.
Name a single-celled eukaryote that boasts a small genome size, is easily cultivated in haploid form, for which a wide variety of molecular genetic tools are available, and that exhibits a simple,...
Xia, Dong, Sanderson, Sanya J, Jones, Andrew R, Prieto, Judith H, Yates, John R, Bromley, Elizabeth, ...
A proteomics analysis identifies one third of the predicted Toxoplasma gondii proteins and integrates proteomics and genomics data to refine genome annotation.
Chen, ZhongQiang, Harb, Omar S., Roos, David S.
Apicomplexan parasites, including the human pathogens Toxoplasma gondii and Plasmodium falciparum, employ specialized secretory organelles (micronemes, rhoptries, dense granules) to invade and...
Reranking candidate gene models with cross-species comparison for improved gene prediction
Liu, Qian, Crammer, Koby, Pereira, Fernando CN, Roos, David S
Saito, Tomoya, Nishi, Manami, Lim, Muoy I., Wu, Bo, Maeda, Takuya, Hashimoto, Hisayuki, ...
We previously reported a cytosolic pyruvate kinase (EC 2.7.1.40) from Toxoplasma gondii (TgPyKI) that differs from most eukaryotic pyruvate kinases in being regulated by glucose 6-phosphate rather...
Aurrecoechea, Cristina, Brestelli, John, Brunk, Brian P., Carlton, Jane M., Dommer, Jennifer, Fischer, Steve, ...
GiardiaDB (http://GiardiaDB.org) and TrichDB (http://TrichDB.org) house the genome databases for Giardia lamblia and Trichomonas vaginalis, respectively, and represent the latest additions to the...
PlasmoDB: a functional genomic database for malaria parasites
Aurrecoechea, Cristina, Brestelli, John, Brunk, Brian P., Dommer, Jennifer, Fischer, Steve, Gajria, Bindu, ...
PlasmoDB (http://PlasmoDB.org) is a functional genomic database for Plasmodium spp. that provides a resource for data analysis and visualization in a gene-by-gene or genome-wide scale. PlasmoDB...
Dynamic Imaging of CD8+ T Cells and Dendritic Cells during Infection with Toxoplasma gondii
John, Beena, Harris, Tajie H., Tait, Elia D., Wilson, Emma H., Gregg, Beth, Ng, Lai Guan, ...
To better understand the initiation of CD8+ T cell responses during infection, the primary response to the intracellular parasite Toxoplasma gondii was characterized using 2-photon microscopy...