Regulation of human endometrial function: mechanisms relevant to uterine bleeding (2006)
Critchley, Hilary OD, Kelly, Rodney W, Baird, David T, Brenner, Robert M
Abstract This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn (or blocked) and menstrual bleeding ensues. A detailed understanding of these local...
Narvekar, Nitish, Critchley, Hilary O.D., Cheng, Linan, Baird, David T.
BACKGROUND: We have previously shown that the progesterone antagonist mifepristone is a contraceptive when given in a dose of 2 or 5 mg per day. The majority of women experience amenorrhoea rather...
Narvekar, Nitish, Critchley, Hilary O.D., Cheng, Linan, Baird, David T.
BACKGROUND: We have previously shown that the progesterone antagonist mifepristone is a contraceptive when given in a dose of 2 or 5 mg per day. The majority of women experience amenorrhoea rather...
Narvekar, Nitish, Critchley, Hilary O.D., Cheng, Linan, Baird, David T.
BACKGROUND: We have previously shown that the progesterone antagonist mifepristone is a contraceptive when given in a dose of 2 or 5 mg per day. The majority of women experience amenorrhoea rather...
Loumaye, Ernest, Engrand, Patrick, Shoham, Zeev, Hillier, Stephen G., Baird, David T.
BACKGROUND: The objective of these studies was to test the hypothesis that over‐dosing with recombinant human LH (rLH) during the late follicular phase would suppress the development of...
Yong, Peter Y.K., Baird, David T., Thong, K.Joo, McNeilly, Alan S., Anderson, Richard A.
BACKGROUND: Analyses of the follicular reserve and activity of the ovary are central to our understanding of the regulation of follicular development. We have carried out a prospective analysis of...
Follicle stimulating hormone (FSH) plays an important role in gametogenesis in both men and women. In men it is required for the establishment and probably maintenance of spermatogenesis. In women it...
Bartley, Julia, Brown, Audrey, Elton, Rob, Baird, David T.
BACKGROUND: Gemeprost and misoprostol are two of the most widely used prostaglandins in combination with mifepristone for medical abortion in early pregnancy. However, the efficacy and side-effects...
Feasibility of administering mifepristone as a once a month contraceptive pill (2001)
Hapangama, Dharani K., Brown, Audrey, Glasier, Anna F., Baird, David T.
Many women find the idea of a once-a-month contraceptive pill an attractive concept. Mifepristone has been shown to be effective as a contraceptive if administered in the early luteal phase. We...
Martin, Cameron W., Riley, Simon C., Everington, Dawn, Groome, Nigel P., Riemersma, Rudolph A., Baird, David T., ...
Prototype hormonal male contraceptive regimens generally achieve only incomplete suppression to azoospermia with potentially adverse metabolic effects. We have carried out a short-term dose-finding...
Overview of advances in contraception (2000)
For most of man′s existence, natural checks on fertility ensured that the numbers of the population more or less matched the resources available. It is only in the last few generations that man has...
Anderson, Richard A., Kinniburgh, David, Baird, David T.
Therapeutic regimens for the treatment of malignant disease may compromise future fertility. One approach to circumvent this is the cryopreservation of embryos created before treatment for the...
Cameron, Sharon T., Critchley, Hilary O.D., Buckley, C.Hilary, Chard, Tim, Kelly, Rodney W., Baird, David T.
The purpose of this study was to assess the ability of the anti-progestin onapristone administered in the immediate post-ovulatory period to disrupt endometrial differentiation as a potential method...
Cameron, Sharon T., Critchley, Hilary O.D., Thong, K. Joo, Buckley, C. Hilary, Williams, Alistair R., Baird, David T.
Following an ovulatory control cycle, six women took 2 mg of mifepristone daily for 30 days. Endometrial biopsies were collected in the control cycle between 7 and 11 days after the plasma...
Baird, David T., Thong, K.J., Hall, C., Cameron, S.T.
It has been demonstrated previously that administration of the antiprogestin mifepristone (RU 486; 1–5 mg daily) inhibits or delays both the pre-ovulatory luteinizing hormone (LH) surge and...
Baird, David T., Sukcharoen, Nares, Thong, K.Joo
Mifepristone (600 mg) in combination with a prostaglandin has been demonstrated to be a safe, acceptable alternative to vacuum aspiration for induction of abortion in the first 9 weeks of pregnancy....
Lyall, Helen, Murray, Elizabeth, Glasier, Anna, Baird, David T.
In response to widespread interest by the media, the Human Fertilisation and Embryology Authority (HFEA) recently produced a document entitled ‘Donated Ovarian Tissue in Embryology Research and...
Cheng, Linan, Kelly, Rodney W., Thong, K.Joo, Hume, Robert, Baird, David T.
Prostaglandin dehydrogenase is the main inactivating enzyme for prostaglandins and therefore controls local levels of prostaglandins. Since there is some evidence that the expression of this enzyme...
McKinley, Carolyn, Thong, K. Joo, Baird, David T.
Although it has been demonstrated that a combination of mifepristone and a prostaglandin is an effective method of inducing abortion in early pregnancy, the optimum dose of the antigestogen is...
West, Christine P., Lumsden, Mary Ann, Hillier, Heideh, Sweeting, Vicky, Baird, David T.
Twenty women with symptomatic uterine fibroids were treated with the luteinizing hormone-releasing hormone (LHRH) agonist goserelin (Zoladex) combined with medroxy-progesterone acetate (MPA) in an...
Glucose phosphate isomerase activity in mouse and human eggs and pre-embryos (1989)
West, John D., Flockhart, Jean H., Angell, Roslyn R., Hillier, Stephen G., Thatcher, Samuel S., Glasier, Anna F., ...
We have measured the activity of glucose phosphate isomerase (GPI-1) in 12 unfertilized human eggs and five human preembryos relative to the GPI-1 activity in C57BL/OlaWs mouse eggs. The GPI-1...
West, John D., Gosden, John R., Angell, Roslyn R., West, Katrine M., Glasier, Anna F., Thatcher, Samuel S., ...
We have used DNA-DNA In-situ hybridization with a DNA probe for the human Y-chromosome to distinguish between male and female human pre-embryos. Both biotinylated and tritlated Y-probes worked well...
Thatcher, Sam S., Angell, Ros E., West, John D., Glasier, Anna F., Kelly, Rodney W., Hillier, Stephen G., ...
Forty women undergoing elective sterilization and oocyte donation were randomized in a trial to study the effects of administration of 30 mg of tamoxifen 12 h before injection of human chorionic...
Mechanism of menstrual bleeding / editors David T. Baird and Eileen A. Michie (1985)
Baird, David T, Michie, Eileen
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Regulation of human endometrial function: mechanisms relevant to uterine bleeding
Critchley, Hilary OD, Kelly, Rodney W, Baird, David T, Brenner, Robert M
This review focuses on the complex events that occur in the endometrium after progesterone is withdrawn (or blocked) and menstrual bleeding ensues. A detailed understanding of these local mechanisms...