David W. Sternberg

Activation of serine/threonine kinases by tyrosine phosphorylation in cells transformed by the v-src oncogene. (1992)

Sternberg, David W.

Thesis (Ph. D.)--Rockefeller University.

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

Frantsve, Julie, Schwaller, Juerg, Sternberg, David W., Kutok, Jeffery, Gilliland, D. Gary

TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease...

Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

Tomasson, Michael H., Sternberg, David W., Williams, Ifor R., Carroll, Martin, Cain, Danielle, Aster, Jon C., ...

The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone marrow transplant (BMT) assay to test the...

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...

Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...

Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation

Frantsve, Julie, Schwaller, Juerg, Sternberg, David W., Kutok, Jeffery, Gilliland, D. Gary

TEL-JAK2 fusion proteins, which are a result of t(9;12)(p24;p13) translocations associated with human leukemia, activate Stat5 in vitro and in vivo and cause a myelo- and lymphoproliferative disease...

Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581

Tomasson, Michael H., Sternberg, David W., Williams, Ifor R., Carroll, Martin, Cain, Danielle, Aster, Jon C., ...

The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone marrow transplant (BMT) assay to test the...

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

Mohi, M. Golam, Boulton, Christina, Gu, Ting-Lei, Sternberg, David W., Neuberg, Donna, Griffin, James D., ...

Abnormal protein tyrosine kinases (PTKs) cause many human leukemias. For example, BCR/ABL causes chronic myelogenous leukemia (CML), whereas FLT3 mutations contribute to the pathogenesis of acute...

Block of C/EBPα function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations

Radomska, Hanna S., Bassères, Daniela S., Zheng, Rui, Zhang, Pu, Dayaram, Tajhal, Yamamoto, Yukiya, ...

Mutations constitutively activating FLT3 kinase are detected in ∼30% of acute myelogenous leukemia (AML) patients and affect downstream pathways such as extracellular signal–regulated kinase...