Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus familial transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Manica, Andrea, Balloux, Francois, Owen, Robert J., Graham, David Y., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Horizontal versus Familial Transmission of Helicobacter pylori (2008)
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, Francois, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographic...
An African origin for the intimate association between humans and Helicobacter pylori (2007)
Linz, Bodo, Balloux, François, Moodley, Yoshan, Manica, Andrea, Liu, Hua, Roumagnac, Philippe, ...
Iron Deficiency and Helicobacter pylori Infection in the United States (2006)
Cardenas, Victor M., Mulla, Zuber D., Ortiz, Melchor, Graham, David Y.
Using data from the current National Health and Nutrition Examination Survey (1999–2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and...
Development of a vaccine against Helicobacter pylori (2005)
Aebischer, Toni, Bumann, Dirk, Epple, H. J., Graham, David Y., Metzger, Wolfram G., Schneider, T., ...
Iron Deficiency and Helicobacter pylori Infection in the United States (2005)
Cardenas, Victor M., Mulla, Zuber D., Ortiz, Melchor, Graham, David Y.
Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and...
Iron Deficiency and Helicobacter pylori Infection in the United States (2005)
Cardenas, Victor M., Mulla, Zuber D., Ortiz, Melchor, Graham, David Y.
Using data from the current National Health and Nutrition Examination Survey (1999-2000), the authors assessed whether Helicobacter pylori infection is associated with iron deficiency and...
Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques (2003)
Dore, Maria Pina, Sepulveda, Antonia R., Bacciu, Piero Paolo, Blasi, Francesco, Simula, Luigi, Marras, Lea, ...
Chronic infections have been associated with cardiovascular disease. We used bacterial culture, polymerase chain reaction (PCR), and immunohistochemical staining with anti-vacA and anticagA...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush,Daniel, Wirth,Thierry, Linz,Bodo, Pritchard,Jonathan K., Stephens,Matthew, Kidd,Mark, ...
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive...
Traces of human migrations in Helicobacter pylori populations (2003)
Falush, Daniel, Wirth, Thierry, Linz, Bodo, Pritchard, Jonathan K., Stephens, Matthew, Kidd, Mark, ...
Dore, Maria Pina, Malaty, Hoda M., Graham, David Y., Fanciulli, Giuseppe, Delitala, Giuseppe, Realdi, Giuseppe
Factors influencing the pattern of Helicobacter pylori infection among children living in adjacent urban and rural areas of northern Sardinia, Italy, were compared. The seroprevalence of H. pylori...
Isolation of helicobacter pylori from sheep-implications for transmission to humans (2001)
Dore, Maria Pina, Sepulveda, Antonia R, El-Zimaity, Hala M., Yamaoka, Yoshio, Osato, Michael S., Mototsugu, Kato, ...
Objectives: When and how Helicobacter pylori(H. pylori) originally entered the human population as well as how the infection is transmitted in different communities is unknown. We previously showed...
Kim, Jae J., Reddy, Rita, Lee, Miae, Kim, Jong G., Osato, Michael S., ...
Antibiotic resistance in Helicobacter pylori varies according to geographical region. We studied the primary resistance rates among 652 H. pylori isolated from Korea in relation to collection date,...
Kwon, Dong H., Peña, Jeremy A., Osato, Michael S., Fox, James G., Graham, David Y., Versalovic, James
In Helicobacter pylori, the oxygen-insensitive nitroreductase RdxA is likely to activate metronidazole (Mtz) by reduction and formation of cytotoxic intermediates. Mutations in rdxA have been...
Realdi, Giuseppe, Dore, Maria Pina, Piana, Andrea Fausto, Atzei, Antonella, Carta, Monica, Cugia, Luigi, ...
Background. Although combinations of antibiotics and antisecretory drugs are useful for treatment of Helicobacter pylori infection, treatment failure is common. The aim of this study was to evaluate...
Amoxycillin tolerance in Helicobacter pylori (1999)
Dore, Maria P., Osato, Michael S., Realdi, Giuseppe, Mura, Ida, Graham, David Y., Sepulveda, Antonia R.
Resistance to amoxycillin in Helicobacter pylori has only recently been reported. To demonstrate the existence of resistance, and to test for the presence of tolerance, 17 amoxycillin-resistant...
Dore, Maria Pina, Piana, Andrea Fausto, Carta, Mario, Atzei, Aldo, Are, Bianca Maria, Mura, Ida Iolanda, ...
Background: The efficacy of omeprazole and amoxycillin dual therapy to treat Helicobacter pylori infection has been inconsistent, suggesting the presence of host or bacterial factors influencing...
Malaty, Hoda M., Graham, David Y., Isaksson, Inger, Engstrand, Lars, Pedersen, Nancy L.
The rate of Helicobacter pylori infection is inversely related to socioeconomic status, and childhood is thought to be the major acquisition period. The authors investigated the importance of...
Dore, Maria Pina, Osato, Michael S., Kwon, Dong H., Graham, David Y.
With use of multiple- and single-colony expansion procedures, the results of susceptibility testing of Helicobacter pylori isolates from patients with duodenal ulcer were assessed by Etest. The H....
Malaty, Hoda M., Kim, Jong G., Kim, Soon D., Graham, David Y.
The prevalence of Helicobacter pylori infection in US adults was shown to be inversely correlated with the socioeconomic status of the family during childhood, and it was suggested that this was...
A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori
Yamaoka, Yoshio, Kwon, Dong H., Graham, David Y.
The complete genome sequence revealed a family of 32 outer membrane proteins (OMPs) in Helicobacter pylori. We examined the effect of four OMPs (HP0638, HP0796, HP1501, and babA2) on the production...
Miehlke, Stephan, Thomas, Rachel, Guiterrez, Oscar, Graham, David Y., Go, Mae F.
In each of six gastric cancer patients, repetitive extragenic palindromic PCR DNA fingerprints of 18 single colonies of Helicobacter pylori from the gastric antrum, corpus, and cardia were identical...
Yamaoka, Yoshio, Kodama, Tadashi, Gutierrez, Oscar, Kim, Jong G., Kashima, Kei, Graham, David Y.
There is continuing interest in identifying Helicobacter pylori virulence factors that might predict the risk for symptomatic clinical outcomes. It has been proposed that iceA and cagA genes are such...
Malaty, Hoda M., Kumagai, Toshiko, Tanaka, Eiji, Ota, Hiroyoshi, Kiyosawa, Kendo, Graham, David Y., ...
We examined the longitudinal changes of Helicobacter pylori infection within 46 families with children and 48 couples without children living in Japan. The study cohort was monitored from 1986 to...
Serum Immunoglobulin G Immune Response to Helicobacter pylori Antigens in Mongolian Gerbils
Kumagai, Toshiko, Yan, Jing, Graham, David Y., Tozuka, Minoru, Okimura, Yukie, Ikeno, Tatsuo, ...
The Mongolian gerbil model for Helicobacter pylori infection is an animal model that mimics human disease. We examined the serum immune response to H. pylori infection in gerbils by enzyme-linked...
Sensitivity of Amoxicillin-Resistant Helicobacter pylori to Other Penicillins
Dore, Maria P., Graham, David Y., Sepulveda, Antonia R., Realdi, Giuseppe, Osato, Michael S.
The sensitivities to penicillins and to a penicillin and β-lactamase inhibitor combination agent were determined for Helicobacter pylori strains that were sensitive, moderately resistant, or highly...
Kwon, Dong-Hyeon, Kato, Mototsugu, Osato, Michael S., Reddy, Rita, Yamaoka, Yoshio, ...
Metronidazole (Mtz) is a critical ingredient of modern multidrug therapies for Helicobacter pylori infection. Mtz resistance reduces the effectiveness of these combinations. Although null mutations...
Kato, Mototsugu, Yamaoka, Yoshio, Kim, Jae J., Reddy, Rita, Asaka, Masahiro, Kashima, Kei, ...
The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and...
Nurgalieva, Zhannat Z., Almuchambetova, R., Machmudova, A., Kapsultanova, D., Osato, Michael S., Peacock, Jeffrey, ...
Studies are difficult in areas lacking modern facilities due to the inability to reliably collect, store, and ship samples. Thus, we sought to evaluate the use of a dry plasma collection device for...
Hansen, Per Syrak, Go, Mae F., Varming, Kim, Andersen, Leif P., Genta, Robert M., Graham, David Y., ...
Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from...
Isolation and Characterization of Tetracycline-Resistant Clinical Isolates of Helicobacter pylori
Kwon, Dong H., Kim, J. J., Lee, M., Yamaoka, Y., Kato, M., Osato, M. S., ...
Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 μg/ml were...
Shortridge, Virginia D., Stone, Gregory G., Flamm, Robert K., Beyer, Jill, Versalovic, James, Graham, David Y., ...
Yamaoka, Yoshio, Kodama, Tadashi, Kashima, Kei, Graham, David Y., Sepulveda, Antonia R.
The CagA protein of Helicobacter pylori is an immunogenic antigen of variable size and unknown function that has been associated with increased virulence as well as two mutually exclusive diseases,...
Miehlke, Stephan, Meining, Alexander, Morgner, Andrea, Bayerdörffer, Ekkehard, Lehn, Norbert, Stolte, Manfred, ...
The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and...
Houseflies Are an Unlikely Reservoir or Vector for Helicobacter pylori
Osato, Michael S., Ayub, Kamran, Le, Hong-Hahn, Reddy, Rita, Graham, David Y.
The route of transmission of Helicobacter pylori from individual to individual remains undefined. It has recently been reported that the domestic housefly, Musca domestica, when fed pure cultures of...
Yamaoka, Yoshio, Kodama, Tadashi, Graham, David Y., Kashima, Kei
We compared four tests for antibodies to CagA or VacA, HelicoBlot 2.0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot...
Yamaoka, Yoshio, Souchek, Julianne, Odenbreit, Stefan, Haas, Rainer, Arnqvist, Anna, Borén, Thomas, ...
The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal...
Marchildon, Patrice A., Sugiyama, Toshiro, Fukada, Yoshihiro, Peacock, Jeffrey S., Asaka, Masahiro, Shimoyama, Takashi, ...
It has been suggested that enzyme immunoassay (EIA) kits validated in one region may yield variable diagnostic performance results in different regions, possibly due to strain-specific differences in...
New Serological Assay for Detection of Putative Helicobacter pylori Virulence Factors
Park, Chang-Young, Cho, Yong-Kyun, Kodama, Tadashi, Osato, Michael S., Graham, David Y., ...
We evaluated a new immunoblot assay (Helicoblot 2.1) for Helicobacter pylori infection and CagA and VacA status by using serum samples from 222 patients. The test accurately detected H. pylori...
Park, Chang-Young, Kwak, Minjung, Gutierrez, Oscar, Graham, David Y., Yamaoka, Yoshio
PCR for vacA and cagA genotypes of Helicobacter pylori using DNA isolated from infected gastric biopsy specimens was approximately equal to genotyping using bacterial DNA from cultures. Inconsistent...
Marchildon, Patrice A., Sugiyama, Toshiro, Fukuda, Yoshihiro, Peacock, Jeffrey S., Asaka, Masahiro, Shimoyama, Takashi, ...
Effects of Tunicamycin on Rotavirus Morphogenesis and Infectivity
Petrie, Betty L., Estes, Mary K., Graham, David Y.
The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not...
Vilaichone, Ratha-Korn, Mahachai, Varocha, Kositchaiwat, Chomsri, Graham, David Y., Yamaoka, Yoshio
The identification of Helicobacter pylori-strain specific factors that correlate with clinical outcome has remained elusive. We investigated possible relationships between a group of H. pylori...
Lee, Keun-Hwa, Cho, Myung-Je, Yamaoka, Yoshio, Graham, David Y., Yun, Yeo-Jun, Woo, So-Yon, ...
Geographical differences in the genetic diversity of Helicobacter pylori isolates were examined by analyzing rpoB sequences. An extremely high level of allelic diversity among H. pylori strains was...
Wu, Jeng Yih, Kim, Jae J., Reddy, Rita, Wang, W. M., Graham, David Y., Kwon, Dong H.
Tetracycline-resistant Helicobacter pylori strains have been increasingly reported worldwide. However, only a small number of tetracycline-resistant strains have been studied with regard to possible...
B-Cell and T-Cell Immune Responses to Experimental Helicobacter pylori Infection in Humans
Nurgalieva, Zhannat Z., Conner, Margaret E., Opekun, Antone R., Zheng, Carl Q., Elliott, Susan N., Ernst, Peter B., ...
The acute antibody and T-cell immune response to Helicobacter pylori infection in humans has not been studied systematically. Serum from H. pylori-naive volunteers challenged with H. pylori and cured...
Yamaoka, Yoshio, Yamauchi, Kazuyoshi, Ota, Hiroyoshi, Sugiyama, Atsushi, Ishizone, Satoshi, Graham, David Y., ...
Data regarding the chronological changes in gastric mucosal cytokines in the different phases of Helicobacter pylori infection are unavailable. We examined Mongolian gerbils for up to 52 weeks after...
Lu, Hong, Wu, Jeng Yih, Kudo, Takahiko, Ohno, Tomoyuki, Graham, David Y., Yamaoka, Yoshio
The regulation of Helicobacter pylori induced interleukin (IL)-6 in the gastric epithelium remains unclear. Primary gastric epithelial cells and MKN28 cells were cocultured with H. pylori and its...
Kudo, Takahiko, Lu, Hong, Wu, Jeng Yih, Graham, David Y., Casola, Antonella, Yamaoka, Yoshio
RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the...
Correlation between Helicobacter pylori OipA Protein Expression and oipA Gene Switch Status
Kudo, Takahiko, Nurgalieva, Zhannat Z., Conner, Margaret E., Crawford, Sue, Odenbreit, Stefan, Haas, Rainer, ...
Polyclonal antisera to either a synthetic OipA peptide or a recombinant OipA protein detected OipA expression in Helicobacter pylori and correlated with functional oipA status determined by PCR...
A Mr 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori
Yamaoka, Yoshio, Kwon, Dong H., Graham, David Y.
The complete genome sequence revealed a family of 32 outer membrane proteins (OMPs) in Helicobacter pylori. We examined the effect of four OMPs (HP0638, HP0796, HP1501, and babA2) on the production...
Miehlke, Stephan, Thomas, Rachel, Guiterrez, Oscar, Graham, David Y., Go, Mae F.
In each of six gastric cancer patients, repetitive extragenic palindromic PCR DNA fingerprints of 18 single colonies of Helicobacter pylori from the gastric antrum, corpus, and cardia were identical...
Yamaoka, Yoshio, Kodama, Tadashi, Gutierrez, Oscar, Kim, Jong G., Kashima, Kei, Graham, David Y.
There is continuing interest in identifying Helicobacter pylori virulence factors that might predict the risk for symptomatic clinical outcomes. It has been proposed that iceA and cagA genes are such...
Malaty, Hoda M., Kumagai, Toshiko, Tanaka, Eiji, Ota, Hiroyoshi, Kiyosawa, Kendo, Graham, David Y., ...
We examined the longitudinal changes of Helicobacter pylori infection within 46 families with children and 48 couples without children living in Japan. The study cohort was monitored from 1986 to...
Serum Immunoglobulin G Immune Response to Helicobacter pylori Antigens in Mongolian Gerbils
Kumagai, Toshiko, Yan, Jing, Graham, David Y., Tozuka, Minoru, Okimura, Yukie, Ikeno, Tatsuo, ...
The Mongolian gerbil model for Helicobacter pylori infection is an animal model that mimics human disease. We examined the serum immune response to H. pylori infection in gerbils by enzyme-linked...
Sensitivity of Amoxicillin-Resistant Helicobacter pylori to Other Penicillins
Dore, Maria P., Graham, David Y., Sepulveda, Antonia R., Realdi, Giuseppe, Osato, Michael S.
The sensitivities to penicillins and to a penicillin and β-lactamase inhibitor combination agent were determined for Helicobacter pylori strains that were sensitive, moderately resistant, or highly...
Kwon, Dong-Hyeon, Kato, Mototsugu, Osato, Michael S., Reddy, Rita, Yamaoka, Yoshio, ...
Metronidazole (Mtz) is a critical ingredient of modern multidrug therapies for Helicobacter pylori infection. Mtz resistance reduces the effectiveness of these combinations. Although null mutations...
Kato, Mototsugu, Yamaoka, Yoshio, Kim, Jae J., Reddy, Rita, Asaka, Masahiro, Kashima, Kei, ...
The patterns of antibiotic resistance in Helicobacter pylori were assessed in two different regions in Japan. Overall, prevalences of resistance to metronidazole and clarithromycin were 12.4 and...
Nurgalieva, Zhannat Z., Almuchambetova, R., Machmudova, A., Kapsultanova, D., Osato, Michael S., Peacock, Jeffrey, ...
Studies are difficult in areas lacking modern facilities due to the inability to reliably collect, store, and ship samples. Thus, we sought to evaluate the use of a dry plasma collection device for...
Hansen, Per Syrak, Go, Mae F., Varming, Kim, Andersen, Leif P., Genta, Robert M., Graham, David Y., ...
Chronic Helicobacter pylori infection is associated with mucosal inflammation. The aim of the present study was to assess human neutrophil and monocyte activation by H. pylori strains obtained from...
Isolation and Characterization of Tetracycline-Resistant Clinical Isolates of Helicobacter pylori
Kwon, Dong H., Kim, J. J., Lee, M., Yamaoka, Y., Kato, M., Osato, M. S., ...
Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 μg/ml were...
Shortridge, Virginia D., Stone, Gregory G., Flamm, Robert K., Beyer, Jill, Versalovic, James, Graham, David Y., ...
Yamaoka, Yoshio, Kodama, Tadashi, Kashima, Kei, Graham, David Y., Sepulveda, Antonia R.
The CagA protein of Helicobacter pylori is an immunogenic antigen of variable size and unknown function that has been associated with increased virulence as well as two mutually exclusive diseases,...
Miehlke, Stephan, Meining, Alexander, Morgner, Andrea, Bayerdörffer, Ekkehard, Lehn, Norbert, Stolte, Manfred, ...
The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and...
Houseflies Are an Unlikely Reservoir or Vector for Helicobacter pylori
Osato, Michael S., Ayub, Kamran, Le, Hong-Hahn, Reddy, Rita, Graham, David Y.
The route of transmission of Helicobacter pylori from individual to individual remains undefined. It has recently been reported that the domestic housefly, Musca domestica, when fed pure cultures of...
Yamaoka, Yoshio, Kodama, Tadashi, Graham, David Y., Kashima, Kei
We compared four tests for antibodies to CagA or VacA, HelicoBlot 2.0, RIDA Blot Helicobacter, CHIRON RIBA H. pylori SIA, and an enzyme-linked immunosorbent assay using recombinant CagA. Immunoblot...
Yamaoka, Yoshio, Souchek, Julianne, Odenbreit, Stefan, Haas, Rainer, Arnqvist, Anna, Borén, Thomas, ...
The BabA, cagA, and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal...
Marchildon, Patrice A., Sugiyama, Toshiro, Fukada, Yoshihiro, Peacock, Jeffrey S., Asaka, Masahiro, Shimoyama, Takashi, ...
It has been suggested that enzyme immunoassay (EIA) kits validated in one region may yield variable diagnostic performance results in different regions, possibly due to strain-specific differences in...
New Serological Assay for Detection of Putative Helicobacter pylori Virulence Factors
Park, Chang-Young, Cho, Yong-Kyun, Kodama, Tadashi, Osato, Michael S., Graham, David Y., ...
We evaluated a new immunoblot assay (Helicoblot 2.1) for Helicobacter pylori infection and CagA and VacA status by using serum samples from 222 patients. The test accurately detected H. pylori...
Park, Chang-Young, Kwak, Minjung, Gutierrez, Oscar, Graham, David Y., Yamaoka, Yoshio
PCR for vacA and cagA genotypes of Helicobacter pylori using DNA isolated from infected gastric biopsy specimens was approximately equal to genotyping using bacterial DNA from cultures. Inconsistent...
Marchildon, Patrice A., Sugiyama, Toshiro, Fukuda, Yoshihiro, Peacock, Jeffrey S., Asaka, Masahiro, Shimoyama, Takashi, ...
Effects of Tunicamycin on Rotavirus Morphogenesis and Infectivity
Petrie, Betty L., Estes, Mary K., Graham, David Y.
The functions of the two rotavirus glycoproteins were investigated by using tunicamycin and a variant of SA11 rotavirus having nonglycosylated VP7. Results showed that glycosylation of VP7 is not...
Vilaichone, Ratha-Korn, Mahachai, Varocha, Kositchaiwat, Chomsri, Graham, David Y., Yamaoka, Yoshio
The identification of Helicobacter pylori-strain specific factors that correlate with clinical outcome has remained elusive. We investigated possible relationships between a group of H. pylori...
Correlation between Helicobacter pylori OipA Protein Expression and oipA Gene Switch Status
Kudo, Takahiko, Nurgalieva, Zhannat Z., Conner, Margaret E., Crawford, Sue, Odenbreit, Stefan, Haas, Rainer, ...
Polyclonal antisera to either a synthetic OipA peptide or a recombinant OipA protein detected OipA expression in Helicobacter pylori and correlated with functional oipA status determined by PCR...
Lee, Keun-Hwa, Cho, Myung-Je, Yamaoka, Yoshio, Graham, David Y., Yun, Yeo-Jun, Woo, So-Yon, ...
Geographical differences in the genetic diversity of Helicobacter pylori isolates were examined by analyzing rpoB sequences. An extremely high level of allelic diversity among H. pylori strains was...
Wu, Jeng Yih, Kim, Jae J., Reddy, Rita, Wang, W. M., Graham, David Y., Kwon, Dong H.
Tetracycline-resistant Helicobacter pylori strains have been increasingly reported worldwide. However, only a small number of tetracycline-resistant strains have been studied with regard to possible...
B-Cell and T-Cell Immune Responses to Experimental Helicobacter pylori Infection in Humans
Nurgalieva, Zhannat Z., Conner, Margaret E., Opekun, Antone R., Zheng, Carl Q., Elliott, Susan N., Ernst, Peter B., ...
The acute antibody and T-cell immune response to Helicobacter pylori infection in humans has not been studied systematically. Serum from H. pylori-naive volunteers challenged with H. pylori and cured...
Yamaoka, Yoshio, Yamauchi, Kazuyoshi, Ota, Hiroyoshi, Sugiyama, Atsushi, Ishizone, Satoshi, Graham, David Y., ...
Data regarding the chronological changes in gastric mucosal cytokines in the different phases of Helicobacter pylori infection are unavailable. We examined Mongolian gerbils for up to 52 weeks after...
Lu, Hong, Wu, Jeng Yih, Kudo, Takahiko, Ohno, Tomoyuki, Graham, David Y., Yamaoka, Yoshio
The regulation of Helicobacter pylori induced interleukin (IL)-6 in the gastric epithelium remains unclear. Primary gastric epithelial cells and MKN28 cells were cocultured with H. pylori and its...
Kudo, Takahiko, Lu, Hong, Wu, Jeng Yih, Graham, David Y., Casola, Antonella, Yamaoka, Yoshio
RANTES, a CC chemokine, plays an important role in the inflammatory response associated with Helicobacter pylori infection. However, the mechanism by which H. pylori induces RANTES expression in the...
Leung, Wai K., Kim, Jae J., Kim, Jong G., Graham, David Y., Sepulveda, Antonia R.
The role and significance of microsatellite instability (MSI) in gastric carcinogenesis remain unknown. This study determined the chronology of MSI in gastric carcinogenesis by examining intestinal...
Salama, Nina R., Gonzalez-Valencia, Gerardo, Deatherage, Brooke, Aviles-Jimenez, Francisco, Atherton, John C., Graham, David Y., ...
Genetic diversity of the human gastric pathogen Helicobacter pylori in an individual host has been observed; whether this diversity represents diversification of a founding strain or a mixed...
Hoda M. Malaty, David Y. Graham
The discovery of Helicobacter pylori revolutionised thinking about the cause of peptic ulcer disease. The most common causes of peptic ulcers are H. pylori infection and use of nonsteroidal...
Horizontal versus Familial Transmission of Helicobacter pylori
Schwarz, Sandra, Morelli, Giovanna, Kusecek, Barica, Manica, Andrea, Balloux, Francois, Owen, Robert J., ...
Transmission of Helicobacter pylori is thought to occur mainly during childhood, and predominantly within families. However, due to the difficulty of obtaining H. pylori isolates from large...
Norwalk Virus Shedding after Experimental Human Infection
Atmar, Robert L., Opekun, Antone R., Gilger, Mark A., Estes, Mary K., Crawford, Sue E., Neill, Frederick H., ...
Noroviruses are shed in feces up to 8 weeks after infection.
Sugimoto, Mitsushige, Wu, Jeng-Yih, Abudayyeh, Suhaib, Hoffman, Jill, Brahem, Hajer, Al-Khatib, Khaldun, ...
The aim of this study was to compare published Helicobacter pylori primer pairs for their ability to reliably detect H. pylori in gastric biopsy specimens and salivary samples. Detection limits of...