David Zahrieh

Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays (2004)

Mutter, George L, Zahrieh, David, Liu, Chunmei, Neuberg, Donna, Finkelstein, David, Baker, Heather E, ...

Abstract Background Primary human tissues are an invaluable widely used tool for discovery of gene expression patterns which characterize disease states. Tissue processing methods remain...

Ferroportin1 is required for normal iron cycling in zebrafish

Fraenkel, Paula G., Traver, David, Donovan, Adriana, Zahrieh, David, Zon, Leonard I.

Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst...

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

Görgün, Güllü, Holderried, Tobias A.W., Zahrieh, David, Neuberg, Donna, Gribben, John G.

To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic...

Ferroportin1 is required for normal iron cycling in zebrafish

Fraenkel, Paula G., Traver, David, Donovan, Adriana, Zahrieh, David, Zon, Leonard I.

Missense mutations in ferroportin1 (fpn1), an intestinal and macrophage iron exporter, have been identified between transmembrane helices 3 and 4 in the zebrafish anemia mutant weissherbst...

Chronic lymphocytic leukemia cells induce changes in gene expression of CD4 and CD8 T cells

Görgün, Güllü, Holderried, Tobias A.W., Zahrieh, David, Neuberg, Donna, Gribben, John G.

To examine the impact of tumors on the immune system, we compared global gene expression profiles of peripheral blood T cells from previously untreated patients with B cell chronic lymphocytic...

Autologous and allogeneic stem cell transplantations for poor-risk chronic lymphocytic leukemia

Gribben, John G., Zahrieh, David, Stephans, Katherine, Bartlett-Pandite, Lini, Alyea, Edwin P., Fisher, David C., ...

We report here on the long-term follow-up on 162 patients with high-risk chronic lymphocytic leukemia (CLL) who have undergone hematopoietic stem cell transplantation (SCT) at a single center from...

Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide

Zirlik, Katja Mauerer, Zahrieh, David, Neuberg, Donna, Gribben, John G.

Heteroclitic peptide modifications increase immunogenicity, allowing generation of cytotoxic T lymphocytes (CTLs) against weakly immunogenic tumor-associated antigens (TAAs). A critical issue is...

Eμ-TCL1 mice represent a model for immunotherapeutic reversal of chronic lymphocytic leukemia-induced T-cell dysfunction

Gorgun, Gullu, Ramsay, Alan G., Holderried, Tobias A. W., Zahrieh, David, Le Dieu, Rifca, Liu, Fenglong, ...

Preclinical animal models have largely ignored the immune-suppressive mechanisms that are important in human cancers. The identification and use of such models should allow better predictions of...