Characterization of the trans-Activation Properties of Equine Herpesvirus 1 EICP0 Protein
Bowles, Dawn E., Kim, Seong K., O'Callaghan, Dennis J.
The EICP0 protein of equine herpesvirus 1 (EHV-1) is an early, viral regulatory protein that independently trans-activates EHV-1 immediate-early (IE), early, γ1 late, and γ2 late promoters. To...
Bowles, Dawn E., Rabinowitz, Joseph E., Samulski, R. Jude
Marker rescue, the restoration of gene function by replacement of a defective gene with a normal one by recombination, has been utilized to produce novel adeno-associated virus (AAV) vectors. AAV...
Rabinowitz, Joseph E., Bowles, Dawn E., Faust, Susan M., Ledford, Julie G., Cunningham, Scott E., Samulski, R. Jude
For all adeno-associated virus (AAV) serotypes, 60 monomers of the Vp1, Vp2, and Vp3 structural proteins assemble via an unknown mechanism to form an intact capsid. In an effort to better understand...
Adeno-associated virus vectors: potential applications for cancer gene therapy
Li, Chengwen, Bowles, Dawn E, Van Dyke, Terry, Samulski, Richard Jude
Augmenting cancer treatment by protein and gene delivery continues to gain momentum based on success in animal models. The primary hurdle of fully exploiting the arsenal of molecular targets and...
Characterization of the trans-Activation Properties of Equine Herpesvirus 1 EICP0 Protein
Bowles, Dawn E., Kim, Seong K., O'Callaghan, Dennis J.
The EICP0 protein of equine herpesvirus 1 (EHV-1) is an early, viral regulatory protein that independently trans-activates EHV-1 immediate-early (IE), early, γ1 late, and γ2 late promoters. To...
Bowles, Dawn E., Rabinowitz, Joseph E., Samulski, R. Jude
Marker rescue, the restoration of gene function by replacement of a defective gene with a normal one by recombination, has been utilized to produce novel adeno-associated virus (AAV) vectors. AAV...
Rabinowitz, Joseph E., Bowles, Dawn E., Faust, Susan M., Ledford, Julie G., Cunningham, Scott E., Samulski, R. Jude
For all adeno-associated virus (AAV) serotypes, 60 monomers of the Vp1, Vp2, and Vp3 structural proteins assemble via an unknown mechanism to form an intact capsid. In an effort to better understand...