DB ARCHER

Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils (2008)

Chan, PH, Pardon, E, Menzer, L, De Genst, E, Kumita, JR, Christodoulou, J, ...

A single-domain fragment, cAb-HuL22, of a camelid heavy-chain antibody specific for the active site of human lysozyme has been generated, and its effects on the properties of the 156T and D67H...

Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88 (2007)

PEL, HJ, DE WINDE, JH, ARCHER, DB, DYER, PS, HOFMANN, G, SCHAAP, PJ, ...

Reduced global copperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations (2005)

Dumoulin, Mireille, Canet, D, Last, AM, Pardon, E, Archer, DB, Muyldermans, S, ...

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental...

A camelid antibody fragment inhibits the formation of amyloid fibrils by human lysozyme (2003)

Dumoulin, Marie-Josée, Last, AM, Desmyter, A, Decanniere, K, Canet, D, Larsson, G, ...

Amyloid diseases are characterized by an aberrant assembly of a specific protein or protein fragment into fibrils and plaques that are deposited in various organs and tissues(1-3), often with serious...