Trabosh, Valerie A., Divito, Kyle A., D. Aguda, Baltazar, Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S.
Id2 is a member of the helix-loop-helix (HLH) family of transcription regulators known to antagonize basic HLH transcription factors and proteins of the retinoblastoma tumor suppressor family and is...
Characterization and Modulation of Proteins Involved in SM Vesication (2006)
We defined the molecular events leading to SM vesication to develop medical countermeasures for exposure of military personnel and civilians. We blocked SM-induced toxicity using a genetic approach...
Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication (2003)
Sulfur mustard (SM) causes blisters in the skin through a series of cellular changes that we are beginning to identify. Recently, using chemical inhibitors, we found a major role for Ca(2+) and...
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy (2001)
Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.
Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...
Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication (1998)
Sulfar mustard (SM) causes blisters in the skin through a series of cellular changes that we are beginning to identify. In the last year, we found a major role for Ca(2+) and calmodulin in the...
Characterization and Modulation of Proteins Involved in SM Vesication (1998)
Sulfur mustard (SM) causes blisters in the skin through a series of cellular changes that we are beginning to identify. Previously, we found that SM induces markers of differentiation and apoptosis...
Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication (1998)
Sulfur Mustard(SM) causes death and detachment of the basal cells of the epidermis, and thus is a strong vesicating agent. To design a therapeutic strategy, we have examined the role of apoptosis in...
Characterization and Modulation of Proteins Involved in Sulfur Mustard Vesication (1998)
To develop medical countermeasures for exposure of military personnel and civilians, we defined the molecular series of events leading to SM vesication. We made significant headway in elucidating...
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase
Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, ...
Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic...
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy
Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.
Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...
Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence1
Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Luo, RuiBai, Samara, Raed, Jung, Mira, Dritschilo, Anatoly, ...
The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with...
Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase
Simbulan-Rosenthal, Cynthia M., Ly, Danith H., Rosenthal, Dean S., Konopka, Genevieve, Luo, RuiBai, Wang, Zhao-Qi, ...
Poly(ADP-ribose) polymerase (PARP) is implicated in the maintenance of genomic integrity, given that inhibition or depletion of this enzyme increases genomic instability in cells exposed to genotoxic...
Simbulan-Rosenthal, Cynthia M., Haddad, Bassem R., Rosenthal, Dean S., Weaver, Zoë, Coleman, Allen, Luo, RuiBai, ...
Depletion of poly(ADP-ribose) polymerase (PARP) increases the frequency of recombination, gene amplification, sister chromatid exchanges, and micronuclei formation in cells exposed to genotoxic...
Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy
Simbulan-Rosenthal, Cynthia M., Rosenthal, Dean S., Luo, RuiBai, Li, Jia-He, Zhang, Jie, Smulson, Mark E.
Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic...
Poly(ADP-ribosyl)ation of p53 In Vitro and In Vivo Modulates Binding to its DNA Consensus Sequence1
Simbulan-Rosenthal, Cynthia M, Rosenthal, Dean S, Luo, RuiBai, Samara, Raed, Jung, Mira, Dritschilo, Anatoly, ...
The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with...