Debasish Chattopadhyay

An unexpected phosphate binding site in Glyceraldehyde 3-Phosphate Dehydrogenase: Crystal structures of apo, holo and ternary complex of Cryptosporidium parvumenzyme (2009)

Cook, William J, Senkovich, Olga, Chattopadhyay, Debasish

Abstract Background The structure, function and reaction mechanism of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) have been extensively studied. Based on these studies, three anion binding sites...

ART AND IDEOLOGY IN MAHASWETA DEVI'S IN THE NAME OF THE MOTHER (2007)

CHATTOPADHYAY, DEBASISH; English, Calcutta University; 13.debasish@gmail.com

ART AND IDEOLOGY IN MAHASWETA DEVI’S IN THE NAME OF THE MOTHER -DEBASISH CHATTOPADHYAY Colonised India witnessed the emergence of a literature that posed a perennial threat to British Imperialism....

Crystal structure of vaccinia virus uracil-DNA glycosylase reveals dimeric assembly (2007)

Schormann, Norbert, Grigorian, Alexei, Samal, Alexandra, Krishnan, Raman, DeLucas, Lawrence, Chattopadhyay, Debasish

Abstract Background Uracil-DNA glycosylases (UDGs) catalyze excision of uracil from DNA. Vaccinia virus, which is the prototype of poxviruses, encodes a UDG (vvUDG) that is significantly different...

Leader RNA binding ability of chandipura virus P protein is regulated by its phosphorylation status: a possible role in genome transcription-replication switch (2003)

Basak, Soumen, Raha, Tamal, Chattopadhyay, Debasish, Majumde, Amitabha, Shaila, MS, Chattopadhyay, DJ

The molecular events associated with the transcriptive and replicative cycle of negative-stranded RNA viruses are still an enigma. We took Chandipura virus, a member of the Rhabdoviridae family, as...

Crystallization, X-Ray Structure Determination and Structure-Based Drug Design for Targeted Malarial Enzymes (1998)

Chattopadhyay, Debasish

Malaria poses major threat to public health worldwide. The situation is worsened by the rapid emergence of strains resistant to existing drugs. There is a tremendous need to develop new potent drugs...

Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas' Disease

Senkovich, Olga, Bhatia, Vandanajay, Garg, Nisha, Chattopadhyay, Debasish

Trypanosoma cruzi, a protozoan parasite, is the causative agent for Chagas' disease, which poses serious public health problem in Latin America. The two drugs available for the treatment of this...

Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.

Recacha, Rosario, Costanzo, Michael J, Maryanoff, Bruce E, Chattopadhyay, Debasish

The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have...

Lipophilic Antifolate Trimetrexate Is a Potent Inhibitor of Trypanosoma cruzi: Prospect for Chemotherapy of Chagas' Disease

Senkovich, Olga, Bhatia, Vandanajay, Garg, Nisha, Chattopadhyay, Debasish

Trypanosoma cruzi, a protozoan parasite, is the causative agent for Chagas' disease, which poses serious public health problem in Latin America. The two drugs available for the treatment of this...

Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.

Recacha, Rosario, Costanzo, Michael J, Maryanoff, Bruce E, Chattopadhyay, Debasish

The fructose-based sugar sulphamate RWJ-37497, a potent analogue of the widely used anti-epileptic drug topiramate, possesses anti-convulsant and carbonic anhydrase-inhibitory activities. We have...

Selective Phosphorylation of Antiviral Drugs by Vaccinia Virus Thymidine Kinase▿

Prichard, Mark N., Keith, Kathy A., Johnson, Mary P., Harden, Emma A., McBrayer, Alexis, Luo, Ming, ...

The antiviral activity of a new series of thymidine analogs was determined against vaccinia virus (VV), cowpox virus (CV), herpes simplex virus, and varicella-zoster virus. Several compounds were...