Debbie A. Lawlor

Height and Site-specific Cancer Risk: A Cohort Study of a Korean Adult Population (2009)

Sung, Joohon, Song, Yun-Mi, Lawlor, Debbie A., Smith, George Davey, Ebrahim, Shah

To evaluate the association between height and risk of cancer in an East Asian, middle-income population, the authors followed up a cohort of 788,789 Koreans (449,214 men and 339,575 women) aged...

Association of the DRD2 gene Taq1A polymorphism and smoking behavior: A meta-analysis and new data (2009)

Munafò, Marcus R., Timpson, Nicholas J., David, Sean P., Ebrahim, Shah, Lawlor, Debbie A.

Introduction: Many studies have investigated the association of the dopamine type-2 receptor (DRD2) Taq1A polymorphism with tobacco use and cigarette smoking behaviors, but findings remain equivocal....

Physical Activity, Mortality, and Cardiovascular Disease: Is Domestic Physical Activity Beneficial?: The Scottish Health Survey--1995, 1998, and 2003 (2009)

Stamatakis, Emmanuel, Hamer, Mark, Lawlor, Debbie A.

Intense domestic physical activity (IDPA) is promoted by preventive health campaigns, but this recommendation is not supported by evidence. The authors used data from the 1995, 1998, and 2003...

Birth weight and risk of type 2 diabetes: a systematic review. (2008)

Whincup, Peter H, Kaye, Samantha J, Owen, Christopher G, Huxley, Rachel, Cook, Derek G, Anazawa, Sonoko, ...

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TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women’s Heart and Health Study 1–4 (2008)

Nic J Timpson, Mikkel Christensen, Debbie A Lawlor, Tom R Gaunt, Ian N Day, Shah Ebrahim, ...

Background: Variation in the perception of bitter tastes has been associated with eating behavior, body composition, and cardiovascular disease. Recent observations have implicated 2 common...

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study (2008)

Kivimäki, Mika, Smith, George Davey, Timpson, Nic J., Lawlor, Debbie A., Batty, G. David, Kähönen, Mika, ...

Aims Mendelian randomization uses genetic variants related to environmentally modifiable risk factors in an attempt to improve causal inference from observational data. We examined the effect of...

Variants in the CRP Gene as a Measure of Lifelong Differences in Average C-Reactive Protein Levels: The Cardiovascular Risk in Young Finns Study, 1980 2001 (2007)

Kivimäki, Mika, Lawlor, Debbie A., Smith, George Davey, Eklund, Carita, Hurme, Mikko, Lehtimäki, Terho, ...

Genetic association studies have used variants in the C-reactive protein (CRP) gene to estimate causal effects of lifelong circulating CRP levels on disease endpoints. However, the extent to which...

Bridging the gap in health inequalities with the help of health trainers: a realistic task in hostile environments? A short report for debate (2007)

Trayers, Tanya, Lawlor, Debbie A.

Background From a public health theoretical perspective, there is acknowledgement that synchronized policies, which address both individual and area level risks to health, are important to reduce...

The Association of Hypertensive Disorders of Pregnancy with Weight Gain over the Subsequent 21 Years: Findings from a Prospective Cohort Study (2007)

Callaway, Leonie K., McIntyre, H. David, O'Callaghan, Michael, Williams, Gail M., Najman, Jake M., Lawlor, Debbie A.

Obesity is an important risk factor for hypertensive disorders of pregnancy, but most cases of hypertensive disorders of pregnancy occur in women of normal weight. There may be predisposing factors...

Growth Trajectory Matters: Interpreting the Associations among Birth Weight, Concurrent Body Size, and Systolic Blood Pressure in a Cohort Study of 378,707 Swedish Men (2007)

Lawlor, Debbie A., Leon, David A., Rasmussen, Finn

The interpretation of the inverse association of birth weight with adult blood pressure after adjustment for concurrent size has been debated. In a large sample (n = 378,707) of Swedish men aged 18...

Cognitive function in childhood and early adulthood and injuries later in life: the Metropolit 1953 male birth cohort (2007)

Osler, Merete, Nybo Andersen, Anne-Marie, Laursen, Bjarne, Lawlor, Debbie A

Background It has been suggested that cognitive function in childhood is a modifiable risk factor for adult injury. This study examines the relationship between cognitive function measured at the age...

Physical Activity and Common Mental Disorder: Results from the Caerphilly Study (2007)

Wiles, Nicola J., Haase, Anne M., Gallacher, John, Lawlor, Debbie A., Lewis, Glyn

The authors examined associations between leisure-time and occupational physical activity and common mental disorder (CMD), defined as anxiety and depression, using data from a cohort of middle-aged...

Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE (2007)

Alharbi, Khalid K., Spanakis, Emmanuel, Tan, Karen, Smith, Matt J., Aldahmesh, Mohammed A., O'Dell, Sandra D., ...

Identification of unknown mutations has remained laborious, expensive, and only viable for studies of selected cases. Population-based "reference ranges" of rarer sequence diversity are not...

Do childhood sleeping problems predict obesity in young adulthood? Evidence from a prospective birth cohort study (2007)

Mamun, Abdullah A., Lawlor, Debbie A., Cramb, Susanna, O'Callaghan, Michael, Williams, Gail, Najman, Jake

It has been suggested that sleeping problems are causally associated with obesity in early life, but most studies examining this association have been cross-sectional. The authors used a...

Epidemiologic Evidence for the Fetal Overnutrition Hypothesis: Findings from the Mater-University Study of Pregnancy and Its Outcomes (2007)

Lawlor, Debbie A., Smith, George Davey, O'Callaghan, Michael, Alati, Rosa, Mamun, Abdullah A., Williams, Gail M., ...

The fetal overnutrition hypothesis proposes that greater maternal adiposity results in increased obesity throughout life in the offspring. The authors examined the associations between parental...

Do Childhood Sleeping Problems Predict Obesity in Young Adulthood? Evidence from a Prospective Birth Cohort Study (2007)

Mamun, Abdullah Al, Lawlor, Debbie A., Cramb, Susanna, O'Callaghan, Michael, Williams, Gail, Najman, Jake

It has been suggested that sleeping problems are causally associated with obesity in early life, but most studies examining this association have been cross-sectional. The authors used a...

Is There a Fetal Origin of Depression? Evidence from the Mater University Study of Pregnancy and Its Outcomes (2007)

Alati, Rosa, Lawlor, Debbie A., Mamun, Abdullah Al, Williams, Gail M., Najman, Jake M., O'Callaghan, Michael, ...

It is unclear whether there is a fetal origin of adult depression. In particular, previous studies have been unable to adjust for the potential effect of maternal depression during pregnancy on any...

Socio-economic position and the use of preventive health care in older British women: a cross-sectional study using data from the British Women's Heart and Health Study cohort (2007)

Patel, Rita, Lawlor, Debbie A., Ebrahim, Shah

Background. Socio-economic inequalities in health may be due to differential uptake of preventive and therapeutic medical services. Objectives. To examine socio-economic position and self-reported...

Physical Activity and Common Mental Disorder: Results from the Caerphilly Study (2007)

Wiles, Nicola J., Haase, Anne M., Gallacher, John, Lawlor, Debbie A., Lewis, Glyn

The authors examined associations between leisure-time and occupational physical activity and common mental disorder (CMD), defined as anxiety and depression, using data from a cohort of middle-aged...

Growth Trajectory Matters: Interpreting the Associations among Birth Weight, Concurrent Body Size, and Systolic Blood Pressure in a Cohort Study of 378,707 Swedish Men (2007)

Lawlor, Debbie A, Leon, David A, Rasmussen, Finn

The interpretation of the inverse association of birth weight with adult blood pressure after adjustment for concurrent size has been debated. In a large sample (n = 378,707) of Swedish men aged 18...

Teenage Children of Teenage Mothers: Psychological, Behavioural and Health Outcomes from an Australian Prospective Longitudinal Study (2006)

Mary Shaw, Debbie A. Lawlor, Jake M. Najman

In many industrialised countries teenage pregnancy and teenage parenthood have in recent years been identified as social and public health problems that need to be tackled. A number of studies have...

Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study (2006)

Mamun, Abdullah Al, Lawlor, Debbie A., Alati, Rosa, O'Callaghan, Michael J., Williams, Gail M., Najman, Jake M.

The authors used a population-based birth cohort of 3,253 children (52% males) born in Brisbane, Australia, between 1981 and 1984 to prospectively examine whether maternal smoking during pregnancy...

Teenage Children of Teenage Mothers: Psychological, Behavioural and Health Outcomes from an Australian Prospective Longitudinal Study (2006)

Mary Shaw, Debbie A. Lawlor, Jake M. Najman

In many industrialised countries teenage pregnancy and teenage parenthood have in recent years been identified as social and public health problems that need to be tackled. A number of studies have...

Does maternal smoking during pregnancy have a direct effect on future offspring obesity? Evidence from a prospective birth cohort study (2006)

Mamun, Abdullah Al, Lawlor, Debbie A., Alati, Rosa, O'Callaghan, Michael J., Williams, Gail M., Najman, Jake M.

The authors used a population-based birth cohort of 3,253 children (52% males) born in Brisbane, Australia, between 1981 and 1984 to prospectively examine whether maternal smoking during pregnancy...

Adult Blood Pressure and Climate Conditions in Infancy: A Test of the Hypothesis that Dehydration in Infancy Is Associated with Higher Adult Blood Pressure (2006)

Lawlor, Debbie A., Davey Smith, George, Mitchell, Richard, Ebrahim, Shah

The authors hypothesized that individuals born in the early 20th century who experienced the hottest and driest summers during infancy would be more likely to have suffered severe infant diarrhea and...

Improving health through neighbourhood environmental change: are we speaking the same language? A qualitative study of views of different stakeholders (2006)

Trayers, Tanya, Deem, Rosemary, Fox, Kenneth R., Riddoch, Chris J., Ness, Andy R., Lawlor, Debbie A.

ObjectiveTo explore the perspectives of four groups of stakeholders to proposed improvements to the built environment--a neighbourhood renewal consisting of a home zone development and an extension...

Association of Body Mass Index with Suicide Mortality: A Prospective Cohort Study of More than One Million Men (2006)

Magnusson, Patrik K. E., Rasmussen, Finn, Lawlor, Debbie A., Tynelius, Per, Gunnell, David

The authors investigated the association of body mass index (BMI) with suicide in a record linkage study based on the Swedish Military Service Conscription Register, the Population and Housing...

Socio-economic position and the use of preventive health care in older British women: a cross-sectional study using data from the British Women's Heart and Health Study cohort (2006)

Patel, Rita, Lawlor, Debbie A, Ebrahim, Shah

Background. Socio-economic inequalities in health may be due to differential uptake of preventive and therapeutic medical services. Objectives. To examine socio-economic position and self-reported...

The Relation between Components of Adult Height and Intimal-Medial Thickness in Middle Age: The Atherosclerosis Risk in Communities Study (2006)

Tilling, Kate, Lawlor, Debbie A., Davey Smith, George, Chambless, Lloyd, Szklo, Moyses

The authors aimed to investigate the relation between components of adult height (leg and trunk length) and atherosclerosis in middle age, using data from 12,254 participants (aged 44–65 years) in...

The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study (2006)

Lawlor, Debbie A., Timpson, Nick, Ebrahim, Shah, Day, Ian NM, Smith, George Davey

Aims One previous study among women with established coronary heart disease found a gene-treatment interaction between the oestrogen receptor gene (ESR1) and hormone replacement in their association...

The association of oestrogen receptor {alpha}-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study (2006)

Lawlor, Debbie A., Timpson, Nick, Ebrahim, Shah, Day, Ian N.M., Smith, George Davey

Aims One previous study among women with established coronary heart disease found a gene–treatment interaction between the oestrogen receptor gene (ESR1) and hormone replacement in their...

Association of Childhood Socioeconomic Position with Cause-specific Mortality in a Prospective Record Linkage Study of 1,839,384 Individuals (2006)

Lawlor, Debbie A., Sterne, Jonathan A. C., Tynelius, Per, Davey Smith, George, Rasmussen, Finn

Previous studies have lacked sufficient power to assess associations between early-life socioeconomic position and adult cause-specific mortality. The authors examined associations of parental social...

Cognitive function in childhood and early adulthood and injuries later in life: the Metropolit 1953 male birth cohort (2006)

Osler, Merete, Nybo Andersen, Anne-Marie, Laursen, Bjarne, Lawlor, Debbie A

Background It has been suggested that cognitive function in childhood is a modifiable risk factor for adult injury. This study examines the relationship between cognitive function measured at the age...

Does Maternal Smoking during Pregnancy Have a Direct Effect on Future Offspring Obesity? Evidence from a Prospective Birth Cohort Study (2006)

Al Mamun, Abdullah, Lawlor, Debbie A., Alati, Rosa, O'Callaghan, Michael J., Williams, Gail M., Najman, Jake M.

The authors used a population-based birth cohort of 3,253 children (52% males) born in Brisbane, Australia, between 1981 and 1984 to prospectively examine whether maternal smoking during pregnancy...

Improving health through neighbourhood environmental change: are we speaking the same language? A qualitative study of views of different stakeholders (2006)

Trayers, Tanya, Deem, Rosemary, Fox, Kenneth R., Riddoch, Chris J., Ness, Andy R., Lawlor, Debbie A.

Objective To explore the perspectives of four groups of stakeholders to proposed improvements to the built environment—a neighbourhood renewal consisting of a home zone development and an extension...

Improving health through neighbourhood environmental change: are we speaking the same language? A qualitative study of views of different stakeholders (2006)

Trayers, Tanya, Deem, Rosemary, Fox, Kenneth R., Riddoch, Chris J., Ness, Andy R., Lawlor, Debbie A.

ObjectiveTo explore the perspectives of four groups of stakeholders to proposed improvements to the built environment--a neighbourhood renewal consisting of a home zone development and an extension...

Socio-economic position and the use of preventive health care in older British women: a cross-sectional study using data from the British Women's Heart and Health Study cohort (2006)

Patel, Rita, Lawlor, Debbie A, Ebrahim, Shah

Background. Socio-economic inequalities in health may be due to differential uptake of preventive and therapeutic medical services. Objectives. To examine socio-economic position and self-reported...

The effect of body mass index changes between ages 5 and 14 on blood pressure at age 14: findings from a birth cohort study (2005)

Mamun, Abdullah A., Lawlor, Debbie A., O'Callaghan, Michael J., Williams, Gail M., Najman, Jake M.

Weight reduction in clinical populations of severely obese children has been shown to have beneficial effects on blood pressure, but little is known about the effect of weight gain among children in...

Association of Body Mass Index with Suicide Mortality: A Prospective Cohort Study of More than One Million Men (2005)

Magnusson, Patrik K. E., Rasmussen, Finn, Lawlor, Debbie A., Tynelius, Per, Gunnell, David

The authors investigated the association of body mass index (BMI) with suicide in a record linkage study based on the Swedish Military Service Conscription Register, the Population and Housing...

The Associations of Physical Activity and Adiposity with Alanine Aminotransferase and Gamma-Glutamyltransferase (2005)

Lawlor, Debbie A., Sattar, Naveed, Smith, George Davey, Ebrahim, Shah

The mechanisms linking obesity and inactivity to diabetes mellitus are unclear. Recent studies have shown associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with...

A comparison of the association between socioeconomic position and cardiovascular disease risk factors in three age cohorts of Australian women: findings from the Australian Longitudinal Study on Women's Health (2005)

Lawlor, Debbie A., Tooth, Leigh, Lee, Christina, Dobson, Annette

Objectives To assess the associations between three measurements of socioeconomic position (SEP) - education, occupation and ability to cope on available income - and cardiovascular risk factors in...

A comparison of the association between socioeconomic position and cardiovascular disease risk factors in three age cohorts of Australian women: findings from the Australian Longitudinal Study on Women's Health (2005)

Lawlor, Debbie A., Tooth, Leigh, Lee, Christina, Dobson, Annette

Objectives To assess the associations between three measurements of socioeconomic position (SEP) – education, occupation and ability to cope on available income – and cardiovascular risk factors...

Association of Body Mass Index with Suicide Mortality: A Prospective Cohort Study of More than One Million Men (2005)

Magnusson, Patrik K. E., Rasmussen, Finn, Lawlor, Debbie A., Tynelius, Per, Gunnell, David

The authors investigated the association of body mass index (BMI) with suicide in a record linkage study based on the Swedish Military Service Conscription Register, the Population and Housing...

A comparison of the association between socioeconomic position and cardiovascular disease risk factors in three age cohorts of Australian women: findings from the Australian Longitudinal Study on Women's Health (2005)

Lawlor, Debbie A., Tooth, Leigh, Lee, Christina, Dobson, Annette

Objectives To assess the associations between three measurements of socioeconomic position (SEP) - education, occupation and ability to cope on available income - and cardiovascular risk factors in...

Associations of Parental, Birth, and Early Life Characteristics With Systolic Blood Pressure at 5 Years of Age: Findings From the Mater-University Study of Pregnancy and Its Outcomes (2004)

Lawlor, Debbie A., Najman, Jake M., Sterne, Jonathan, Williams, Gail M., Ebrahim, Shah, Smith, George Davey

Background-We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age. Methods and Results-Information from 3864 children who...

Chronic diseases, locomotor activity limitation and social participation in older women: cross sectional survey of British Women's Heart and Health Study (2004)

Adamson, Joy, Lawlor, Debbie A., Ebrahim, Shah

Objectives: to examine the association of chronic degenerative diseases with locomotor activity limitation and social participation among older British women. Methods: cross-sectional survey of 4,286...

The challenge of secondary prevention for coronary heart disease in older patients: findings from the British Women's Heart and Health Study and the British Regional Heart Study (2004)

Lawlor, Debbie A, Whincup, Peter, Emberson, Jonathan R, Rees, Karen, Walker, Mary, Ebrahim, Shah

Background. Secondary prevention of coronary heart disease (CHD) among older individuals is associated with considerable benefit. Methods. In this study, we have examined the extent of secondary...

(Mis)use of Factor Analysis in the Study of Insulin Resistance Syndrome (2004)

Lawlor, Debbie A., Ebrahim, Shah, May, Margaret, Davey Smith, George

Over the last decade, factor analysis has been used increasingly to describe patterns of simultaneous occurrence of the central components of the insulin resistance syndrome. In this paper, the...

Is There a Sex Difference in the Association between Birth Weight and Systolic Blood Pressure in Later Life? Findings from a Meta-Regression Analysis (2002)

Lawlor, Debbie A., Ebrahim, Shah, Davey Smith, George

The aim of this study was to determine whether a sex difference exists in the association between birth weight and systolic blood pressure. A meta-analysis of all observational studies (n =...

Indicators of socioeconomic position (part 1)

Galobardes, Bruna, Shaw, Mary, Lawlor, Debbie A, Lynch, John W

This glossary presents a comprehensive list of indicators of socioeconomic position used in health research. A description of what they intend to measure is given together with how data are elicited...

Indicators of socioeconomic position (part 2)

Galobardes, Bruna, Shaw, Mary, Lawlor, Debbie A, Lynch, John W

This is the second part of a glossary on indicators of socioeconomic position used in health research (the first part was published in the January issue of the journal).

Socioeconomic Position, Co-Occurrence of Behavior-Related Risk Factors, and Coronary Heart Disease: the Finnish Public Sector Study

Kivimäki, Mika, Lawlor, Debbie A., Smith, George Davey, Kouvonen, Anne, Virtanen, Marianna, Elovainio, Marko, ...

Objectives. We examined the associations between socioeconomic position, co-occurrence of behavior-related risk factors, and the effect of these factors on the relative and absolute socioeconomic...

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, ...

To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist...