Deborah Braun

Type I IFN sets the stringency of B cell repertoire selection in the bone marrow (1999)

Vasconcellos, Rita, Braun, Deborah, Coutinho, Antonio, Demengeot, Jocelyne

Locally produced type I interferon (IFN-I) enhances the sensitivity of bone marrow B cell to IgM receptor ligation. The establishment of B cell repertoires, on the other hand, seems to involve...

A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

Braun, Deborah, Longman, Randy S., Albert, Matthew L.

Prostaglandins, a family of lipidic molecules released during inflammation, display immunomodulatory properties in several models. One use includes exposure of monocyte-derived dendritic cells (DCs)...

Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells

Zhang, Xiaoming, Deriaud, Edith, Jiao, Xinan, Braun, Deborah, Leclerc, Claude, Lo-Man, Richard

Newborns and infants are highly susceptible to viral and bacterial infections, but the underlying mechanism remains poorly understood. We show that neonatal B cells effectively control the production...

Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation

Doyen, Virginie, Rubio, Manuel, Braun, Deborah, Nakajima, Toshiaru, Abe, Jun, Saito, Hirohisa, ...

Thrombospondin 1 (TSP) elicits potent antiinflammatory activities in vivo, as evidenced by persistent, multiorgan inflammation in TSP null mice. Herein, we report that DCs represent an abundant...