Human Platelets Damage Aspergillus fumigatus Hyphae and May Supplement Killing by Neutrophils
Christin, Laurent, Wysong, Deborah R., Meshulam, Tova, Hastey, Ryan, Simons, Elizabeth R., Diamond, Richard D.
Neutropenia is considered a significant risk factor for invasive aspergillosis but is almost always associated with concurrent thrombocytopenia. Studies determined that platelets, like neutrophils,...
Cloning and Sequencing of a Candida albicans Catalase Gene and Effects of Disruption of This Gene†
Wysong, Deborah R., Christin, Laurent, Sugar, Alan M., Robbins, Phillips W., Diamond, Richard D.
Catalase plays a key role as an antioxidant, protecting aerobic organisms from the toxic effects of hydrogen peroxide, and in some cases has been postulated to be a virulence factor. To help...
Novel Small-Molecule Inhibitors of RNA Polymerase III
Wu, Liping, Pan, Jing, Thoroddsen, Vala, Wysong, Deborah R., Blackman, Ronald K., Bulawa, Christine E., ...
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA...
Human Platelets Damage Aspergillus fumigatus Hyphae and May Supplement Killing by Neutrophils
Christin, Laurent, Wysong, Deborah R., Meshulam, Tova, Hastey, Ryan, Simons, Elizabeth R., Diamond, Richard D.
Neutropenia is considered a significant risk factor for invasive aspergillosis but is almost always associated with concurrent thrombocytopenia. Studies determined that platelets, like neutrophils,...
Cloning and Sequencing of a Candida albicans Catalase Gene and Effects of Disruption of This Gene†
Wysong, Deborah R., Christin, Laurent, Sugar, Alan M., Robbins, Phillips W., Diamond, Richard D.
Catalase plays a key role as an antioxidant, protecting aerobic organisms from the toxic effects of hydrogen peroxide, and in some cases has been postulated to be a virulence factor. To help...
Novel Small-Molecule Inhibitors of RNA Polymerase III
Wu, Liping, Pan, Jing, Thoroddsen, Vala, Wysong, Deborah R., Blackman, Ronald K., Bulawa, Christine E., ...
A genetic approach utilizing the yeast Saccharomyces cerevisiae was used to identify the target of antifungal compounds. This analysis led to the identification of small molecule inhibitors of RNA...
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase
Manfredi, Mark G., Ecsedy, Jeffrey A., Meetze, Kristan A., Balani, Suresh K., Burenkova, Olga, Chen, Wei, ...
Increased Aurora A expression occurs in a variety of human cancers and induces chromosomal abnormalities during mitosis associated with tumor initiation and progression. MLN8054 is a selective...