Merz, Jon F, Kriss, Antigone T, Leonard, Debra G. B., Cho, Mildred K
Questions about the effects of patents and licensing are becoming critical in the United States, Europe and other developed countries as more genes are discovered and patented, and as genetic testing...
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Megonigal, Maureen D., Cheung, Nai-Kong V., Rappaport, Eric F., Nowell, Peter C., Wilson, Robert B., Jones, Douglas H., ...
Leukemias with MLL gene translocations are a complication of primary cancer treatment with DNA topoisomerase II inhibitors. How early translocations appear during primary cancer treatment has not...
Patel, Jean Baldus, Leonard, Debra G. B., Pan, Xai, Musser, James M., Berman, Richard E., Nachamkin, Irving
We evaluated the MicroSeq 500 16S rDNA Bacterial Sequencing Kit (PE Applied Biosystems), a 500-bp sequence-based identification system, for its ability to identify clinical Mycobacterium isolates....
Rennert, Hanna, Zeigler-Johnson, Charnita M., Addya, Kathakali, Finley, Matthew J., Walker, Amy H., Spangler, Elaine, ...
Reported associations of ELAC2/HPC2, RNASEL/HPC1, and MSR1 with prostate cancer have been inconsistent and understudied in African Americans. We evaluated the role of 16 sequence variants in these...
Megonigal, Maureen D., Cheung, Nai-Kong V., Rappaport, Eric F., Nowell, Peter C., Wilson, Robert B., Jones, Douglas H., ...
Leukemias with MLL gene translocations are a complication of primary cancer treatment with DNA topoisomerase II inhibitors. How early translocations appear during primary cancer treatment has not...
Patel, Jean Baldus, Leonard, Debra G. B., Pan, Xai, Musser, James M., Berman, Richard E., Nachamkin, Irving
We evaluated the MicroSeq 500 16S rDNA Bacterial Sequencing Kit (PE Applied Biosystems), a 500-bp sequence-based identification system, for its ability to identify clinical Mycobacterium isolates....
Przybylski, Grzegorz K., Wu, Hong, Macon, William R., Finan, Janet, Leonard, Debra G. B., Felgar, Raymond E., ...
Gamma/delta T cell lymphomas (γ/δ TCL) represent rare, often aggressive types of T cell malignancy that are clinically and pathologically diverse. Most γ/δ TCL occur as a hepatosplenic or...
Oversight of Genetic Testing: An Update
Kaul, Karen L., Leonard, Debra G. B., Gonzalez, Andrea, Garrett, Carleton T.
Heteroduplex Formation in SMN Gene Dosage Analysis
Ogino, Shuji, Leonard, Debra G. B., Rennert, Hanna, Gao, Sizhen, Wilson, Robert B.
Most spinal muscular atrophy patients lack both copies of SMN1 exon 7 and most carriers have only one copy of SMN1 exon 7. We investigated the effect of SMN1/SMN2 heteroduplex formation on SMN gene...
Spinal Muscular Atrophy Genetic Testing Experience at an Academic Medical Center
Ogino, Shuji, Leonard, Debra G. B., Rennert, Hanna, Wilson, Robert B.
Approximately 94% of spinal muscular atrophy (SMA) patients lack both copies of SMN1 exon 7. We report our SMA genetic testing experience (total 1281 cases), using SMA linkage analysis (32 families),...
Salto-Tellez, Manuel, Shelat, Suresh G., Benoit, Bernice, Rennert, Hanna, Carroll, Martin, Leonard, Debra G.B., ...
The aim of this study was to validate the application of a commercially available multiplex reverse transcription polymerase chain reaction (RT-PCR) assay [Hemavision-7 System] for the seven most...
Effects of Patents and Licenses on the Provision of Clinical Genetic Testing Services
Cho, Mildred K., Illangasekare, Samantha, Weaver, Meredith A., Leonard, Debra G. B., Merz, Jon F.
The growth of patents that include genetic sequences has been accompanied by concern about their impact on the ability of physicians to provide clinical genetic testing services and to perform...