Su, Wan-Lin, Modrek, Barmak, GuhaThakurta, Debraj, Edwards, Stephen, Shah, Jyoti K, Kulkarni, Amit V, ...
Abstract Background Studies have shown that genetic and sex differences strongly influence gene expression in mice. Given the diversity and complexity of transcripts produced by alternative splicing,...
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008)
Eric E. Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y. Lum, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...
Debraj Guhathakurta, Gary D. Stormo
Motivation: Transcriptional activation in eukaryotic organisms normally requires combinatorial interactions of multiple transcription factors. Though several methods exist for identification of...
GuhaThakurta, Debraj, Xie, Tao, Anand, Manish, Edwards, Stephen W, Li, Guoya, Wang, Susanna S, ...
Abstract Background Changes in gene expression are known to be responsible for phenotypic variation and susceptibility to diseases. Identification and annotation of the genomic sequence variants that...
Computational identification of transcriptional regulatory elements in DNA sequence (2006)
Identification and annotation of all the functional elements in the genome, including genes and the regulatory sequences, is a fundamental challenge in genomics and computational biology. Since...
Schadt, Eric E, Edwards, Stephen W, GuhaThakurta, Debraj, Holder, Dan, Ying, Lisa, Svetnik, Vladimir, ...
Abstract Background Computational and microarray-based experimental approaches were used to generate a comprehensive transcript index for the human genome. Oligonucleotide probes designed from...
Novel transcription regulatory elements in Caenorhabditis elegans muscle genes (2004)
GuhaThakurta, Debraj, Schriefer, Lawrence A., Waterston, Robert H., Stormo, Gary D.
We report the identification of three new transcription regulatory elements that are associated with muscle gene expression in the nematode Caenorhabditis elegans. Starting from a subset of...
Conserved homvedTqWR proteins (2002)
Interact With Mads, Tata Pramila, Shawna Miles, Debraj Guhathakurta, Dave Jemiolo, Linda L. Breeden
lins,whli directth phctUYNb)[UVY localization and/or substrate specificity of th kinase. Thna is a critical distinction between G1phYE and th rest of th cell cycle, inthw G1 is expandable in response...
Debraj Guhathakurta, Lisanne Palomar, Gary D. Stormo, Pat Tedesco, Christopher D. Link
this article were defrayed in part by payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 USC section 1734 solely to indicate this...
GuhaThakurta, Debraj, Palomar, Lisanne, Stormo, Gary D., Tedesco, Pat, Johnson, Thomas E., Walker, David W., ...
Identifying target sites for cooperatively binding factors (2001)
GuhaThakurta, Debraj, Stormo, Gary D.
Motivation: Transcriptional activation in eukaryotic organisms normally requires combinatorial interactions of multiple transcription factors. Though several methods exist for identification of...
Vita.
GuhaThakurta, Debraj, Palomar, Lisanne, Stormo, Gary D., Tedesco, Pat, Johnson, Thomas E., Walker, David W., ...
We report here the identification of a previously unknown transcription regulatory element for heat shock (HS) genes in Caenorhabditis elegans. We monitored the expression pattern of 11,917 genes...
Pramila, Tata, Miles, Shawna, GuhaThakurta, Debraj, Jemiolo, Dave, Breeden, Linda L.
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle in budding yeast. These proteins bind to...
Novel transcription regulatory elements in Caenorhabditis elegans muscle genes
GuhaThakurta, Debraj, Schriefer, Lawrence A., Waterston, Robert H., Stormo, Gary D.
We report the identification of three new transcription regulatory elements that are associated with muscle gene expression in the nematode Caenorhabditis elegans. Starting from a subset of...
Schadt, Eric E, Edwards, Stephen W, GuhaThakurta, Debraj, Holder, Dan, Ying, Lisa, Svetnik, Vladimir, ...
A combination of microarray data with extensive genome annotations resulted in a set of 28,456 experimentally supported transcripts, providing the first experiment-driven annotation of the human...
Computational identification of transcriptional regulatory elements in DNA sequence
Identification and annotation of all the functional elements in the genome, including genes and the regulatory sequences, is a fundamental challenge in genomics and computational biology. Since...
GuhaThakurta, Debraj, Palomar, Lisanne, Stormo, Gary D., Tedesco, Pat, Johnson, Thomas E., Walker, David W., ...
We report here the identification of a previously unknown transcription regulatory element for heat shock (HS) genes in Caenorhabditis elegans. We monitored the expression pattern of 11,917 genes...
Pramila, Tata, Miles, Shawna, GuhaThakurta, Debraj, Jemiolo, Dave, Breeden, Linda L.
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle in budding yeast. These proteins bind to...
Novel transcription regulatory elements in Caenorhabditis elegans muscle genes
GuhaThakurta, Debraj, Schriefer, Lawrence A., Waterston, Robert H., Stormo, Gary D.
We report the identification of three new transcription regulatory elements that are associated with muscle gene expression in the nematode Caenorhabditis elegans. Starting from a subset of...
Schadt, Eric E, Edwards, Stephen W, GuhaThakurta, Debraj, Holder, Dan, Ying, Lisa, Svetnik, Vladimir, ...
A combination of microarray data with extensive genome annotations resulted in a set of 28,456 experimentally supported transcripts, providing the first experiment-driven annotation of the human...
Computational identification of transcriptional regulatory elements in DNA sequence
Identification and annotation of all the functional elements in the genome, including genes and the regulatory sequences, is a fundamental challenge in genomics and computational biology. Since...
Mapping the Genetic Architecture of Gene Expression in Human Liver
Schadt, Eric E, Molony, Cliona, Chudin, Eugene, Hao, Ke, Yang, Xia, Lum, Pek Y, ...
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order...