Denis Soulet

Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion (2009)

Smith, Ruben, Bacos, Karl, Fedele, Valentina, Soulet, Denis, Walz, Helena A., Obermüller, Stefanie, ...

Huntington's disease is a severe progressive neurodegenerative disorder caused by a CAG expansion in the IT15 gene, which encodes huntingtin. The disease primarily affects the neostriatum and...

Les polyamines : transport, compartimentation et nouveau rôle biologique / (2004)

Soulet, Denis.

Thèse (Ph. D.)--Université Laval, 2004.

Role of endocytosis in the internalization of spermidine-C(2)-BODIPY, a highly fluorescent probe of polyamine transport.

Soulet, Denis, Covassin, Laurence, Kaouass, Mohammadi, Charest-Gaudreault, René, Audette, Marie, Poulin, Richard

The mechanism of transmembrane polyamine internalization in mammalian cells remains unknown. A novel fluorescent spermidine conjugate [Spd-C(2)-BODIPY;...

Role of endocytosis in the internalization of spermidine-C(2)-BODIPY, a highly fluorescent probe of polyamine transport.

Soulet, Denis, Covassin, Laurence, Kaouass, Mohammadi, Charest-Gaudreault, René, Audette, Marie, Poulin, Richard

The mechanism of transmembrane polyamine internalization in mammalian cells remains unknown. A novel fluorescent spermidine conjugate [Spd-C(2)-BODIPY;...

Polyamines play a critical role in the control of the innate immune response in the mouse central nervous system

Soulet, Denis, Rivest, Serge

The present work investigated whether polyamines play a role in the control of the innate immune response in the brain. The first evidence that these molecules may be involved in such a process was...

A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease

Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, ...

Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by both neurological and systemic abnormalities. We examined the peripheral immune system and found widespread...