Deniz Kirik

Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration (2009)

Carlsson, Thomas, Carta, Manolo, Muñoz, Ana, Mattsson, Bengt, Winkler, Christian, Kirik, Deniz, ...

Previous studies have shown that serotonin neurons play an important role in the induction and maintenance of l-DOPA-induced dyskinesia in animals with lesion of the nigrostriatal dopamine system....

Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia (2008)

Muñoz, Ana, Li, Qin, Gardoni, Fabrizio, Marcello, Elena, Qin, Chuan, Carlsson, Thomas, ...

Appearance of dyskinesia is a common problem of long-term l-DOPA treatment in Parkinson's disease patients and represents a major limitation for the pharmacological management of the motor symptoms...

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats (2007)

Carta, Manolo, Carlsson, Thomas, Kirik, Deniz, Björklund, Anders

In patients with Parkinson's disease, the therapeutic efficacy of l-DOPA medication is gradually lost over time, and abnormal involuntary movements, dyskinesias, gradually emerge as a prominent...

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. (2007)

Eslamboli, Andisheh, Romero-Ramos, Marina, Burger, Corinna, Bjorklund, Tomas, Muzyczka, Nicholas, Mandel, Ronald J, ...

Abstract is not available

Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy. (2007)

Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

Abstract is not available

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats. (2007)

Carta, Manolo, Carlsson, Thomas, Kirik, Deniz, Bjorklund, Anders

Abstract is not available

Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy. (2007)

Carlsson, Thomas, Bjorklund, Tomas, Kirik, Deniz

Abstract is not available

Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat. (2007)

Kanter-Schlifke, Irene, Georgievska, Biljana, Kirik, Deniz, Kokaia, Merab

Abstract is not available

The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease. (2007)

Breysse, Nathalie, Carlsson, Thomas, Winkler, Christian, Bjorklund, Anders, Kirik, Deniz

Abstract is not available

Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. (2007)

Carlsson, Thomas, Carta, Manolo, Winkler, Christian, Björklund, Anders, Kirik, Deniz

Abstract is not available

Murine models of acute neuronopathic Gaucher disease. (2007)

Enquist, Ida Berglin, Bianco, Christophe Lo, Ooka, Andreas, Nilsson, Eva, Mansson, Jan-Eric, Ehinger, Mats, ...

Abstract is not available

In vivo gene delivery for development of mammalian models for Parkinson's disease. (2007)

Ulusoy, Ayse, Bjorklund, Tomas, Hermening, Stephan, Kirik, Deniz

Abstract is not available

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain (2007)

Eslamboli, Andisheh, Romero-Ramos, Marina, Burger, Corinna, Bjorklund, Tomas, Muzyczka, Nicholas, Mandel, Ronald J., ...

Overexpression of human α-synuclein (α-syn) using recombinant adeno-associated viral (rAAV) vectors provides a novel tool to study neurodegenerative processes seen in Parkinson's disease and other...

Ventral tegmental area dopamine neurons are resistant to human mutant alpha-synuclein overexpression. (2006)

Maingay, Matthew, Romero-Ramos, Marina, Carta, Manolo, Kirik, Deniz

Abstract is not available

Targeted in utero delivery of a retroviral vector for gene transfer in the rodent brain. (2006)

Stott, Simon R W, Kirik, Deniz

Abstract is not available

Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. (2005)

Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J, Cenci, Angela, ...

Abstract is not available

Viral Vector Mediated Overexpression of Human alpha-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's Disease. (2005)

Maingay, Matthew, Romero-Ramos, Marina, Kirik, Deniz

Abstract is not available

Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changes. (2005)

Popovic, Natalija, Maingay, Matthew, Kirik, Deniz, Brundin, Patrik

Abstract is not available

Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts. (2005)

Sørensen, Andreas Toft, Thompson, Lachlan, Kirik, Deniz, Björklund, Anders, Lindvall, Olle, Kokaia, Merab

Abstract is not available

Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections. (2005)

Thompson, Lachlan, Barraud, Perrine, Andersson, Elin, Kirik, Deniz, Björklund, Anders

Abstract is not available

Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse. (2005)

Barraud, Perrine, Thompson, Lachlan, Kirik, Deniz, Bjorklund, Anders, Parmar, Malin

Abstract is not available

Imaging in cell-based therapy for neurodegenerative diseases. (2005)

Kirik, Deniz, Breysse, Nathalie, Bjorklund, Tomas, Besret, Laurent, Hantraye, Philippe

Abstract is not available

Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia. (2005)

Carlsson, Thomas, Winkler, Christian, Lundblad, Martin, Cenci, M Angela, Bjorklund, Anders, Kirik, Deniz

Abstract is not available

Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results (2005)

Kirik, Deniz, Björklund, Anders

Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors (2005)

Carlsson, Thomas, Winkler, Christian, Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Cenci, Angela, ...

Dyskinesias are a major complication of long-term l-3,4-dihydroxyphenylalanine (l-DOPA) treatment in Parkinson's disease, and are believed to result from the intermittent and pulsatile supply of...

Localized striatal delivery of GDNF as a treatment for Parkinson disease. (2004)

Kirik, Deniz, Georgievska, Biljana, Björklund, Anders

Abstract not available.

Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. (2004)

Georgievska, Biljana, Kirik, Deniz, Björklund, Anders

Abstract is not available

Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector. (2004)

Georgievska, Biljana, Jakobsson, Johan, Persson, Elisabeth, Ericson, Cecilia, Kirik, Deniz, Lundberg, Cecilia

Abstract is not available

Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor. (2004)

Georgievska, Biljana, Carlsson, Thomas, Lacar, Benjamin, Winkler, Christian, Kirik, Deniz

Abstract is not available

Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system. (2003)

Rosenblad, Carl, Georgievska, Biljana, Kirik, Deniz

Sustained neurotrophic factor treatment in neurodegenerative disorders such as Parkinson's disease is likely to affect both degenerating and intact neurons. To investigate the effect of long-term...

Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease. (2003)

Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Bjorklund, Anders

Abstract is not available

Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. (2003)

Gustafsson, Elin, Andsberg, Gunnar, Darsalia, Vladimer, Mohapel, Paul, Mandel, Ronald J., Kirik, Deniz, ...

Abstract is not available

Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors. (2003)

Kirik, Deniz, Björklund, Anders

Abstract is not available

Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats. (2003)

Arvidsson, Andreas, Kirik, Deniz, Lundberg, Cecilia, Mandel, Ronald J, Andsberg, Gunnar, Kokaia, Zaal, ...

Abstract is not available

Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. (2002)

Kirik, Deniz, Rosenblad, Carl, Burger, Corinna, Lundberg, Cecilia, Johansen, Teit E, Muzyczka, Nicholas, ...

Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant...

Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector. (2002)

Georgievska, Biljana, Kirik, Deniz, Rosenblad, Carl, Lundberg, Cecilia, Björklund, Anders

We used a recombinant lentiviral vector (rLV) for gene delivery of GDNF to the striatum, and assessed its neuroprotective effects in the intrastriatal 6-hydroxydopamine (6-OHDA) lesion model.The...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. (2002)

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J, ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of L-dopa in animals with lesions of the nigrostriatal pathway. The functional...

L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function. (2002)

Winkler, Christian, Kirik, Deniz, Björklund, Anders, Cenci, M Angela

In order to assess the role of striatal dopamine (DA) afferents in L-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine...

Neuronal replacement from endogenous precursors in the adult brain after stroke. (2002)

Arvidsson, Andreas, Collin, Tove, Kirik, Deniz, Kokaia, Zaal, Lindvall, Olle

In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease....

Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. (2002)

Georgievska, Biljana, Kirik, Deniz, Björklund, Anders

Abstract is not available

Restorative and neuroprotective treatment strategies for Parkinson’s disease. Studies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors. (2001)

Kirik, Deniz

The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the...

Restorative and neuroprotective treatment strategies for Parkinson's disease. Studies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors (2001)

Kirik, Deniz

The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson's disease. This thesis work (1) describes the...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...

Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease

Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders

We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The α-synuclein protein was expressed in...

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of l-dopa using rAAV-mediated gene transfer

Kirik, Deniz, Georgievska, Biljana, Burger, Corinna, Winkler, Christian, Muzyczka, Nicholas, Mandel, Ronald J., ...

Intrastriatal delivery of the tyrosine hydroxylase gene by viral vectors is being explored as a tool for local delivery of l-dopa in animals with lesions of the nigrostriatal pathway. The functional...

Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease

Kirik, Deniz, Annett, Lucy E., Burger, Corinna, Muzyczka, Nicholas, Mandel, Ronald J., Björklund, Anders

We used a high-titer recombinant adeno-associated virus (rAAV) vector to express WT or mutant human α-synuclein in the substantia nigra of adult marmosets. The α-synuclein protein was expressed in...

Murine models of acute neuronopathic Gaucher disease

Enquist, Ida Berglin, Bianco, Christophe Lo, Ooka, Andreas, Nilsson, Eva, Månsson, Jan-Eric, Ehinger, Mats, ...

Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the glucosidase, beta, acid (GBA) gene that encodes the lysosomal enzyme glucosylceramidase (GCase)....