Derek A. Denton

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance (2008)

Jayasooriya, Anura P., Mathai, Michael L., Walker, Lesley L., Begg, Denovan P., Denton, Derek A., Cameron-Smith, David, ...

In addition to its role in the storage of fat, adipose tissue acts as an endocrine organ, and it contains a functional renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE) plays a key...

Effect of sodium loading and ACTH on blood pressure of sheep with reduced renal mass (1979)

WHITWORTH, JUDITH A., COGHLAN, JOHN P., DENTON, DEREK A., HARDY, KENNETH J., SCOGGINS, BRUCE A.

Sodium chloride loading produced a rise in blood pressure in intact sheep which was potentiated by reduction in renal mass. ACTH induced hypertension was also potentiated by reduced renal mass,...

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.

Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting...

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering

Boon, Wee-Ming, Beissbarth, Tim, Hyde, Lavinia, Smyth, Gordon, Gunnersen, Jenny, Denton, Derek A., ...

The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to...

Human medullary responses to cooling and rewarming the skin: A functional MRI study

McAllen, Robin M., Farrell, Michael, Johnson, John M., Trevaks, David, Cole, Leonie, McKinley, Michael J., ...

A fall in skin temperature precipitates a repertoire of thermoregulatory responses that reduce the likelihood of a decrease in core temperature. Studies in animals suggest that medullary raphé...

Unique, common, and interacting cortical correlates of thirst and pain

Farrell, Michael J., Egan, Gary F., Zamarripa, Frank, Shade, Robert, Blair-West, John, Fox, Peter, ...

This study used positron-emission tomography to establish the patterns of brain activity involved in the isolated and concurrent experiences of thirst and pain. Ten subjects were scanned while...

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice

Halaas, Jeffrey L., Boozer, Carol, Blair-West, John, Fidahusein, Naseem, Denton, Derek A., Friedman, Jeffrey M.

Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue. High leptin levels are observed in obese humans and rodents, suggesting...

A comparative analysis of transcribed genes in the mouse hypothalamus and neocortex reveals chromosomal clustering

Boon, Wee-Ming, Beissbarth, Tim, Hyde, Lavinia, Smyth, Gordon, Gunnersen, Jenny, Denton, Derek A., ...

The hypothalamus and neocortex are subdivisions of the mammalian forebrain, and yet, they have vastly different evolutionary histories, cytoarchitecture, and biological functions. In an attempt to...

Human medullary responses to cooling and rewarming the skin: A functional MRI study

McAllen, Robin M., Farrell, Michael, Johnson, John M., Trevaks, David, Cole, Leonie, McKinley, Michael J., ...

A fall in skin temperature precipitates a repertoire of thermoregulatory responses that reduce the likelihood of a decrease in core temperature. Studies in animals suggest that medullary raphé...

Unique, common, and interacting cortical correlates of thirst and pain

Farrell, Michael J., Egan, Gary F., Zamarripa, Frank, Shade, Robert, Blair-West, John, Fox, Peter, ...

This study used positron-emission tomography to establish the patterns of brain activity involved in the isolated and concurrent experiences of thirst and pain. Ten subjects were scanned while...

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance

Jayasooriya, Anura P., Mathai, Michael L., Walker, Lesley L., Begg, Denovan P., Denton, Derek A., Cameron-Smith, David, ...

In addition to its role in the storage of fat, adipose tissue acts as an endocrine organ, and it contains a functional renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE) plays a key...

Basis for the preferential activation of cardiac sympathetic nerve activity in heart failure

Ramchandra, Rohit, Hood, Sally G., Denton, Derek A., Woods, Robin L., McKinley, Michael J., McAllen, Robin M., ...

In heart failure (HF), sympathetic nerve activity is increased. Measurements in HF patients of cardiac norepinephrine spillover, reflecting cardiac sympathetic nerve activity (CSNA), indicate that it...