Cationic microparticles: A potent delivery system for DNA vaccines
Singh, Manmohan, Briones, Maylene, Ott, Gary, O'Hagan, Derek
An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection....
Ryan, Elizabeth J., McNeela, Edel, Murphy, Geraldine A., Stewart, Helen, O'hagan, Derek, Pizza, Mariagrazia, ...
Mucosal delivery of vaccines is dependent on the identification of safe and effective adjuvants that can enhance the immunogenicity of protein antigens administered by nasal or oral routes. In this...
Scharton-Kersten, Tanya, Yu, Jian-mei, Vassell, Russell, O'Hagan, Derek, Alving, Carl R., Glenn, Gregory M.
We have recently described a needle-free method of vaccination, transcutaneous immunization, consisting of the topical application of vaccine antigens to intact skin. While most proteins themselves...
O'Hagan, Derek, Singh, Manmohan, Ugozzoli, Mildred, Wild, Carl, Barnett, Susan, Chen, Minchao, ...
The effectiveness of cationic microparticles with adsorbed DNA at inducing immune responses was investigated in mice, guinea pigs, and rhesus macaques. Plasmid DNA vaccines encoding human...
Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...
Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...
Gupta, Soumi, Janani, Ramesh, Bin, Qian, Luciw, Paul, Greer, Catherine, Perri, Silvia, ...
A safe, replication-defective viral vector that can induce mucosal and systemic immune responses and confer protection against many infectious pathogens, such as human immunodeficiency virus type 1...
Cationic microparticles: A potent delivery system for DNA vaccines
Singh, Manmohan, Briones, Maylene, Ott, Gary, O'Hagan, Derek
An approach involving the preparation of biodegradable microparticles with a cationic surface was developed to improve the delivery of adsorbed DNA into antigen-presenting cells after i.m. injection....
Ryan, Elizabeth J., McNeela, Edel, Murphy, Geraldine A., Stewart, Helen, O'hagan, Derek, Pizza, Mariagrazia, ...
Mucosal delivery of vaccines is dependent on the identification of safe and effective adjuvants that can enhance the immunogenicity of protein antigens administered by nasal or oral routes. In this...
Scharton-Kersten, Tanya, Yu, Jian-mei, Vassell, Russell, O'Hagan, Derek, Alving, Carl R., Glenn, Gregory M.
We have recently described a needle-free method of vaccination, transcutaneous immunization, consisting of the topical application of vaccine antigens to intact skin. While most proteins themselves...
O'Hagan, Derek, Singh, Manmohan, Ugozzoli, Mildred, Wild, Carl, Barnett, Susan, Chen, Minchao, ...
The effectiveness of cationic microparticles with adsorbed DNA at inducing immune responses was investigated in mice, guinea pigs, and rhesus macaques. Plasmid DNA vaccines encoding human...
Otten, Gillis, Schaefer, Mary, Greer, Catherine, Calderon-Cacia, Maria, Coit, Doris, Kazzaz, Jina, ...
Several vaccine technologies were evaluated for their abilities to induce anti-human immunodeficiency virus Gag immune responses in rhesus macaques. While no vaccine alone was able to induce broad...
Gupta, Soumi, Janani, Ramesh, Bin, Qian, Luciw, Paul, Greer, Catherine, Perri, Silvia, ...
A safe, replication-defective viral vector that can induce mucosal and systemic immune responses and confer protection against many infectious pathogens, such as human immunodeficiency virus type 1...
Vaccines with the MF59 Adjuvant Do Not Stimulate Antibody Responses against Squalene
Del Giudice, Giuseppe, Fragapane, Elena, Bugarini, Roberto, Hora, Maninder, Henriksson, Thomas, Palla, Emanuela, ...
Squalene is a naturally occurring oil which has been used in the development of vaccine adjuvants, such as the oil-in-water emulsion MF59. In past years, by use of noncontrolled and nonvalidated...
Vajdy, Michael, Singh, Manmohan, Ugozzoli, Mildred, Briones, Maylene, Soenawan, Elawati, Cuadra, Lina, ...
It is estimated that Helicobacter pylori infects the stomachs of over 50% of the world's population and if not treated may cause chronic gastritis, peptic ulcer disease, gastric adenocarcinoma and...
Dormitzer, Philip R., Rappuoli, Rino, Casini, Daniele, O'Hagan, Derek, Runham, Celene, Montomoli, Emanuele, ...
Pandemic H1N1 influenza vaccine antigens are currently being manufactured. The MF59 adjuvant has an established safety profile in humans and a proven ability to increase responses to some influenza...