Derek T. O'Hagan

Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles (2004)

Mollenkopf,Hans-Joachim, Dietrich,Guido, Fensterle,Joachim, Grode,Leander, Diehl,Klaus-Dieter, Knapp,B, ...

Immunization with plasmid DNA vectors represents a promising new approach to vaccination. It has been shown to elicit humoral and cellular immunity and protection in various infection models. Here,...

Enhanced protective efficacy of a tuberculosis DNA vaccine by adsorption onto cationic PLG microparticles (2004)

Mollenkopf, Hans J., Dietrich, Guido, Fensterle, Joachim, Grode, Leander, Diehl, Klaus-Dieter, Knapp, B, ...

Oral Administration of Influenza Vaccine in Combination with the Adjuvants LT-K63 and LT-R72 Induces Potent Immune Responses Comparable to or Stronger than Traditional Intramuscular Immunization

Barackman, John D., Ott, Gary, Pine, Samuel, O'Hagan, Derek T.

Mucosal immunization strategies are actively being pursued in the hopes of improving the efficacy of vaccines against the influenza virus. Our group investigated the oral immunization of mice via...

CpG Oligodeoxynucleotides Adsorbed onto Polylactide-Co-Glycolide Microparticles Improve the Immunogenicity and Protective Activity of the Licensed Anthrax Vaccine

Xie, Hang, Gursel, Ihsan, Ivins, Bruce E., Singh, Manmohan, O'Hagan, Derek T., Ulmer, Jeffrey B., ...

To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN)...

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

Otten, Gillis R., Schaefer, Mary, Doe, Barbara, Liu, Hong, Srivastava, Indresh, Zur Megede, Jan, ...

DNA vaccines have been used widely in experimental primate models of human immunodeficiency virus (HIV), but their effectiveness has been limited. In this study, we evaluated three technologies for...

Oral Administration of Influenza Vaccine in Combination with the Adjuvants LT-K63 and LT-R72 Induces Potent Immune Responses Comparable to or Stronger than Traditional Intramuscular Immunization

Barackman, John D., Ott, Gary, Pine, Samuel, O'Hagan, Derek T.

Mucosal immunization strategies are actively being pursued in the hopes of improving the efficacy of vaccines against the influenza virus. Our group investigated the oral immunization of mice via...

CpG Oligodeoxynucleotides Adsorbed onto Polylactide-Co-Glycolide Microparticles Improve the Immunogenicity and Protective Activity of the Licensed Anthrax Vaccine

Xie, Hang, Gursel, Ihsan, Ivins, Bruce E., Singh, Manmohan, O'Hagan, Derek T., Ulmer, Jeffrey B., ...

To reduce the biothreat posed by anthrax, efforts are under way to improve the protection afforded by vaccination. This work examines the ability of immunostimulatory CpG oligodeoxynucleotides (ODN)...

Enhanced Potency of Plasmid DNA Microparticle Human Immunodeficiency Virus Vaccines in Rhesus Macaques by Using a Priming-Boosting Regimen with Recombinant Proteins

Otten, Gillis R., Schaefer, Mary, Doe, Barbara, Liu, Hong, Srivastava, Indresh, Zur Megede, Jan, ...

DNA vaccines have been used widely in experimental primate models of human immunodeficiency virus (HIV), but their effectiveness has been limited. In this study, we evaluated three technologies for...

Protection of Rhesus Monkeys by a DNA Prime/Poxvirus Boost Malaria Vaccine Depends on Optimal DNA Priming and Inclusion of Blood Stage Antigens

Weiss, Walter R., Kumar, Anita, Jiang, George, Williams, Jackie, Bostick, Anthony, Conteh, Solomon, ...

Dose-Dependent Protection against or Exacerbation of Disease by a Polylactide Glycolide Microparticle-Adsorbed, Alphavirus-Based Measles Virus DNA Vaccine in Rhesus Macaques▿

Pan, Chien-Hsiung, Nair, Nitya, Adams, Robert J., Zink, M. Christine, Lee, Eun-Young, Polack, Fernando P., ...

Measles remains an important cause of vaccine-preventable child mortality. Development of a low-cost, heat-stable vaccine for infants under the age of 6 months could improve measles control by...

β7-integrin-independent enhancement of mucosal and systemic anti-HIV antibody responses following combined mucosal and systemic gene delivery

Goodsell, Amanda, Zhou, Fengmin, Gupta, Soumi, Singh, Manmohan, Malyala, Padma, Kazzaz, Jina, ...

Vaccination strategies that can block or limit heterosexual human immunodeficiency virus (HIV) transmissions to local and systemic tissues are the goal of much research effort. Herein, in a mouse...

Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome

Sharp, Fiona A., Ruane, Darren, Claass, Benjamin, Creagh, Emma, Harris, James, Malyala, Padma, ...

Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable...